Results 41 to 50 of about 49,138 (272)

Crystal structure of piperazine-1,4-diium bis(4-aminobenzenesulfonate)

Acta Crystallographica Section E: Crystallographic Communications, 2015
The asymmetric unit of the title salt, C4H12N22+·2C6H6NO3S−, consists of half a piperazindiium dication, located about an inversion centre, and a 4-aminobenzenesulfonate anion. The piperazine ring adopts a chair conformation.
K. Sathesh Kumar, S. Ranjith, S. Sudhakar, P. Srinivasan, M. N. Ponnuswamy   +4 more
doaj   +1 more source

Synthesis of Enantiomerically Pure 6‑Substituted-Piperazine-2-Acetic Acid Esters as Intermediates for Library Production

, 2018
The piperazine heterocycle is broadly exploited in FDA-approved drugs and biologically active compounds, but its chemical diversity is usually limited to ring nitrogen substitutions, leaving the four carbon atoms underutilized.
Shiva Krishna Reddy Guduru (5346644), Srinivas Chamakuri (1554262), Conrad Santini (1887550), Damian W. Young (1271631), Kevin R. MacKenzie (2368375), Prashi Jain (1514275), J. Winston Arney (5346641)   +6 more
core   +1 more source

Piperazine-fused cyclic disulfides: high-performance bioreduction-activated cores for bifunctional probes and reagents [PDF]

, 2023
We report piperazine-fused six-membered-cyclic dichalcogenides as rapid-response redox substrates that interface with thiol/disulfide redox biology. Combining the stability of 1,2-dithianes with unprecedentedly rapid kinetics of self-immolation after ...
Jan G., Felber, Leonid, Komissarov, Oliver, Thorn-Seshold, Carina, Schmitt, Alexander J., Wiegand, Karoline C., Scholzen, Lukas, Zeisel, Elias S. J., Arnér   +7 more
core   +2 more sources

Synthesis of N,N‘-Orthogonally Protected (S)-Piperazine-2-carboxylic Acid

, 2016
Synthesis of N,N‘-Orthogonally Protected (S)-Piperazine-2-carboxylic ...
Teng-Man Chen (3041436), Alan M. Warshawsky (3014151), Meena V. Patel (2515885)   +2 more
core   +1 more source

A Holistic Platform Approach for Developing Robust Pulmonary mRNA Delivery: Integrating Novel Phenolic Acid‐Derived Ionizable Lipids and Device Engineering

Advanced Functional Materials, EarlyView.
An integrated pulmonary mRNA delivery platform combining novel biodegradable syringic acid‐derived ionizable lipids, design‐of‐experiments formulation optimization, and vibrating‐mesh nebulizer engineering enabled stable aerosolization and efficient lung delivery.
Neha Kaushal, Younan Ma, Asad Khanmohammed, Dipen Parande, Hanming Zhang, Saket Dolare, Juliet Chen, Apiwat Wangweerawong, Saswata Karmakar, Hongfeng Deng, Frank Koppenhagen, Shraddha Sharma, Eric Reyes, Sherry He, Lianne Boeglin, Caroline Woo, Azadeh Paksa, Ayed Allawzi, Anusha Dias, Gregory Troiano, Shrirang Karve, Frank DeRosa   +21 more
wiley   +1 more source

Generalizable Strategies for the Synthesis of Cereblon‐Recruiting PROTAC Prodrugs

Angewandte Chemie, EarlyView.
Cereblon‐recruiting PROTACs remain challenging to derivatize for prodrug‐based delivery. In this study, three complementary conjugation strategies enabled the efficient synthesis of cleavable PROTAC prodrugs with tunable release kinetics that can be incorporated into a library of PEGylated constructs and bottlebrush prodrugs.
Aiden X. Wang, Bin Liu, Elise M. Ackerman, Yichen Xiang, Hung V.‐T. Nguyen, Yivan Jiang, Angela N. Koehler, Jeremiah A. Johnson   +7 more
wiley   +2 more sources

Green preparation of piperazine pyrophosphate and its application in flame-retardant silicone rubber

Hecheng xiangjiao gongye
The expansive flame retardant pipe-razine pyrophosphate was synthesized via "one pot method" using phosphoric acid and piperazine as raw materials. Fourier transform infrared spectroscopy was employed to characterize the resulting product. The properties
HUANG Lun1,2, YE Dan-yang1,2, JIAO Wei-xian1,2, MENG Xi1,2, LI Wen-juan3
doaj   +1 more source

Piperazine Bridged Thianorrole Dimer

, 2023
Oxidative cyclization of open chain thiabilanes yielded the first examples of unique piperazine bridged thianorrole dimers instead of the expected thianorrole monomer.
Vratta Grover (12441119), Mangalampalli Ravikanth (1559524), Mangalampalli Ravikanth, Poornenth Pushpanandan, Poornenth Pushpanandan (4484788), Vratta Grover   +5 more
core   +1 more source

Esterified Cholesterol Conjugates Enable LNP‐Mediated mRNA Delivery to the Blood–Brain Barrier Following Intravenous Administration

Advanced Materials, EarlyView.
A cholesterol‐conjugated lipid library enabled the identification of a ligand‐free LNP platform for efficient mRNA delivery to brain endothelial cells via systemic administration. This platform achieves selective BBB targeting without disrupting barrier integrity, and enables modulation of neuroinflammation and vascular function without requiring trans‐
Zeru Tian, Xu Wang, Alexis Pacheco Benitez, Erick Guerrero, Yaou Duan, Jingwen Wei, Lukas Farbiak, Daniel J. Siegwart   +7 more
wiley   +1 more source

A Study on the Synthesis and Anticancer Activities of Novel 6-Methoxy Flavonyl Piperazine Derivatives

Proceedings, 2017
Cancer is an extensive and complicated family of malignancies that can affect virtually every part of the body. It is reported that over 1.2 million new cases are diagnosed every year.
Meltem Ceylan-Ünlüsoy, Oya Bozdağ-Dündar   +1 more
doaj   +1 more source