Results 41 to 50 of about 50,209 (265)

Crystal structure of piperazine-1,4-diium bis(4-aminobenzenesulfonate)

Acta Crystallographica Section E: Crystallographic Communications, 2015
The asymmetric unit of the title salt, C4H12N22+·2C6H6NO3S−, consists of half a piperazindiium dication, located about an inversion centre, and a 4-aminobenzenesulfonate anion. The piperazine ring adopts a chair conformation.
K. Sathesh Kumar, S. Ranjith, S. Sudhakar, P. Srinivasan, M. N. Ponnuswamy   +4 more
doaj   +1 more source

Synthesis of Enantiomerically Pure 6‑Substituted-Piperazine-2-Acetic Acid Esters as Intermediates for Library Production

, 2018
The piperazine heterocycle is broadly exploited in FDA-approved drugs and biologically active compounds, but its chemical diversity is usually limited to ring nitrogen substitutions, leaving the four carbon atoms underutilized.
Shiva Krishna Reddy Guduru (5346644), Srinivas Chamakuri (1554262), Conrad Santini (1887550), Damian W. Young (1271631), Kevin R. MacKenzie (2368375), Prashi Jain (1514275), J. Winston Arney (5346641)   +6 more
core   +1 more source

SYNTHESIS of 1-(4-HYDROXYLPHENYL)-4-(4-NITROPHENYL)PIPERAZINE [PDF]

, 2009
Triazole medicines are mainstream of the antifungal medicines, especially used in curing deep department fungal infections and its important intermediate is 1-(4-hydroxylphenyl)-4-(4-nitrophenyl)piperazine. As the key intermediate of antifungal medicines
TANG, Ning, WANG, Quan-quan, HU, Yong, KE, Chang-mei   +3 more
core   +1 more source

Recent advances in photocatalytic hydrogen peroxide production

PhotoMat, EarlyView., 2023
We classify the representative photocatalytic materials for photosynthesis of hydrogen peroxide (H2O2) in recent years and discuss the related modification methods in detail, providing inspiration and insights for the future design of photocatalysts for H2O2 production.
Jinyu Yan, Yuan Li, Yunxiang Li, Shuxin Ouyang, Tierui Zhang   +4 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Green preparation of piperazine pyrophosphate and its application in flame-retardant silicone rubber

Hecheng xiangjiao gongye
The expansive flame retardant pipe-razine pyrophosphate was synthesized via "one pot method" using phosphoric acid and piperazine as raw materials. Fourier transform infrared spectroscopy was employed to characterize the resulting product. The properties
HUANG Lun1,2, YE Dan-yang1,2, JIAO Wei-xian1,2, MENG Xi1,2, LI Wen-juan3
doaj   +1 more source

A Study on the Synthesis and Anticancer Activities of Novel 6-Methoxy Flavonyl Piperazine Derivatives

Proceedings, 2017
Cancer is an extensive and complicated family of malignancies that can affect virtually every part of the body. It is reported that over 1.2 million new cases are diagnosed every year.
Meltem Ceylan-Ünlüsoy, Oya Bozdağ-Dündar   +1 more
doaj   +1 more source

A Holistic Platform Approach for Developing Robust Pulmonary mRNA Delivery: Integrating Novel Phenolic Acid‐Derived Ionizable Lipids and Device Engineering

Advanced Functional Materials, EarlyView.
An integrated pulmonary mRNA delivery platform combining novel biodegradable syringic acid‐derived ionizable lipids, design‐of‐experiments formulation optimization, and vibrating‐mesh nebulizer engineering enabled stable aerosolization and efficient lung delivery.
Neha Kaushal, Younan Ma, Asad Khanmohammed, Dipen Parande, Hanming Zhang, Saket Dolare, Juliet Chen, Apiwat Wangweerawong, Saswata Karmakar, Hongfeng Deng, Frank Koppenhagen, Shraddha Sharma, Eric Reyes, Sherry He, Lianne Boeglin, Caroline Woo, Azadeh Paksa, Ayed Allawzi, Anusha Dias, Gregory Troiano, Shrirang Karve, Frank DeRosa   +21 more
wiley   +1 more source

Proximity‐Induced Protein Deglycosylation by Endogenous O‐GlcNAcase

Angewandte Chemie, EarlyView.
Bifunctional molecules recruit endogenous O‑GlcNAcase to target proteins, enabling selective de‑O‑GlcNAcylation in living cells without perturbing global O‑GlcNAc homeostasis. This work developed a programmable chemical strategy for targeted O‑GlcNAc editing and framework for functional enzymatic recruitment via optimization of competitive enzyme ...
Haixing Xu, Bowen Ma, Yunpeng Huang, Jialin Liu, Billy Wai‐Lung Ng   +4 more
wiley   +2 more sources

Nickel‐Catalyzed Three‐Component Difluoroalkylation‐Amination for the Direct Access to Anti‐Inflammatory β‐Difluoroalkyl Amines

Advanced Science, EarlyView.
A nickel‐catalyzed three‐component reductive fluoroalkylation‐amination strategy of N‐vinylamides for the direct access to the α‐amidyl‐β‐difluoroalkyl amines was reported here. The synthetic method features with broad substrate scope, mild conditions, high functional group tolerance, and convenience to handle.
Chang Xu, Fangting Ma, Fan Ding, Luyan Wang, Yunxi Li, Yunzhi He, Xingang Zhang, Siyu He, Dandan Liu   +8 more
wiley   +1 more source