Results 51 to 60 of about 37,749 (227)

Investigation of piperazines as human carbonic anhydrase I, II, IV and VII activators

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
Four human (h) carbonic anhydrase isoforms (CA, EC 4.2.1.1), hCA I, II, IV, and VII, were investigated for their activation profile with piperazines belonging to various classes, such as N-aryl-, N-alkyl-, N-acyl-piperazines as well as 2,4-disubstituted ...
Andrea Angeli, Niccolò Chiaramonte, Dina Manetti, Maria Novella Romanelli, Claudiu T. Supuran   +4 more
doaj   +1 more source

Hydroxyzine‐induced fixed drug eruption and cross‐reaction with oxatomide

Journal of Cutaneous Immunology and Allergy, 2023
There are a few reports in the literature implicating them in causing fixed drug eruption, the piperazine derivatives. In this case, although eszopiclone for insomnia medicinehas a piperazine ring, no eruption appeared so far.
Mizuki Terada, Shujiro Hayashi, Maki Okamoto, Ken Igawa   +3 more
doaj   +1 more source

MODELING POLARIZATION CURVE IN AN AQUEOUS CARBONATED SOLUTION OF PIPERAZINE

Journal of Engineering and Sustainable Development, 2022
A polarization curve model is developed for carbon steel in an aqueous carbonated solution of piperazine (PZ). This model has been used to generate the polarization curve and control the parameters relevant to the corrosion rate of carbon steel in the PZ-
Lubna Ghalib, Brahim Si Ali, Shaukat Ali Mazari   +2 more
doaj   +1 more source

Multicomponent mannich-type approaches to the synthesis of functionalized piperazine-based bioactive scaffolds

Journal of Saudi Chemical Society
Piperazine is a nitrogen-containing heterocycle widely present in pharmacologically active compounds. Multicomponent strategies, particularly Mannich-type reactions, have proven highly effective for introducing molecular complexity and functional ...
Saeeda Mubashra, Matloob Ahmad, Sana Aslam, Sami A. Al-Hussain, Magdi E. A. Zaki   +4 more
doaj   +1 more source

Peptidthioester und Peptidtriazolderivate durch Duale Modifikation von Peptidthiosulfonaten auf dem Harz

Angewandte Chemie, EarlyView.
Es wird eine Strategie zur dualen Modifikation von Peptiden auf der Festphase vorgestellt, die die S‐Alkinylierung von Peptidthiosulfonaten und eine regioselektive, iridiumkatalysierte Azid‐Thioalkin‐Zykloaddition umfasst. Dieses Verfahren ermöglicht zuverlässig den Zugang zu Peptiden mit komplexen, nicht‐kanonischen Modifikationen und ist mit ...
Marius Werner, Agnes Bergmann, Chenxi Liu, Mira Behnam, Christian Klein, Franziska Thomas   +5 more
wiley   +1 more source

Crystal structure of 7-hydroxy-8-[(4-methylpiperazin-1-yl)methyl]-2H-chromen-2-one

Acta Crystallographica Section E: Crystallographic Communications, 2016
In the title compound, C15H18N2O3, the coumarin ring is essentially planar, with an r.m.s. deviation of 0.012 Å. An intramolecular O—H...N hydrogen bond forms an S(6) ring motif. The piperazine ring adopts a chair conformation.
Koji Kubono, Ryuma Kise, Yukiyasu Kashiwagi, Keita Tani, Kunihiko Yokoi   +4 more
doaj   +1 more source

Antihelminic Activity of Carvacrol, Thymol, Cinnamaldehyde and P-Cymen Against the Free-Living Nematode Caenorhabditis elegans and Rat Pinworm Syphacia muris

Acta Veterinaria, 2018
In the present study we tested the dose andh time dependence of the antinematodal effects of carvacrol and tyhmol on Caenorabditis elegans, and the efficacy of carvacrol, thymol, p-cymene and cinnamaldehyde,which were administrated in the drinking water ...
Marjanović S. Đorđe, Bogunović Danica, Milovanović Mirjana, Marinković Darko, Zdravković Nemanja, Magaš Vladimir, Trailović M. Saša   +6 more
doaj   +1 more source

The crystal structure of 1-(2-iodobenzoyl)-4-(pyrimidin-2-yl)piperazine: a three-dimensional hydrogen-bonded framework, augmented by π–π stacking interactions and I...N halogen bonds

Acta Crystallographica Section E: Crystallographic Communications, 2019
In 1-(2-iodobenzoyl)-4-(pyrimidin-2-yl)piperazine, C15H15IN4O, the central piperazine ring adopts an almost perfect chair conformation with the pyrimidine substituent in an equatorial site.
Ninganayaka Mahesha, Hemmige S. Yathirajan, Tetsundo Furuya, Takashiro Akitsu, Christopher Glidewell   +4 more
doaj   +1 more source

1,4-Bis(2-((1R,5S)-6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethyl)piperazine

Molbank
The reaction of (−)-nopol mesylate with piperazine in acetonitrile under reflux, afforded symmetric 1,4-bis(2-((1R,5S)-6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethyl)piperazine in a good yield.
Nikolai S. Li-Zhulanov, Artem D. Rogachev, Yuri V. Gatilov, Konstantin P. Volcho, Nariman F. Salakhutdinov   +4 more
doaj   +1 more source

Design, Synthesis and Anticancer Screening of Novel Benzothiazole-Piperazine-1,2,3-Triazole Hybrids

Molecules, 2018
A library of novel regioselective 1,4-di and 1,4,5-trisubstituted-1,2,3-triazole based benzothiazole-piperazine conjugates were designed and synthesized using the click synthesis approach in the presence and absence of the Cu(I) catalyst. Some of these 1,
Mohamed R. Aouad, Moataz A. Soliman, Muath O. Alharbi, Sanaa K. Bardaweel, Pramod K. Sahu, Adeeb A. Ali, Mouslim Messali, Nadjet Rezki, Yaseen A. Al-Soud   +8 more
doaj   +1 more source