Results 71 to 80 of about 37,749 (227)

Strain Release of 1‐Azabicyclo[1.1.0]butanes as a Gateway to Highly Functionalized Azetidines: New Strategies and Structural Motifs

Chemistry – A European Journal, EarlyView.
Over the past decade, the interest in azetidines has continuously risen, by virtue of their highly appealing pharmaceutical properties. Monocyclic, spirocyclic, and bridged azetidines can be accessed by leveraging 1‐azabicyclo[1.1.0]butanes as precursors.
Yuri Gelato, Philipp Natho, Marco Colella, Renzo Luisi   +3 more
wiley   +1 more source

1,4-Bis(2-nitrobenzyl)piperazine

IUCrData, 2019
The title compound, C18H20N4O4, was synthesized via the base-assisted reaction of piperazine and 2-nitrobenyl bromide in toluene: the complete molecule is generated by a crystallographic inversion centre in the solid state.
Hugh I. Crundwell, Rhiannon I. Grimmett, Guy Crundwell, Barry L. Westcott   +3 more
doaj   +1 more source

Mechanochemical Amidation Mediated by 1,1’‐Oxalyldiimidazole for the Synthesis of Agrochemicals

Chemistry – A European Journal, EarlyView.
Mechanochemical amidation using 1,1'‐oxalyldiimidazole (ODI) overcomes limitations of 1,1’‐carbonyl diimidazole (CDI) as coupling agent by enabling the efficient mechanochemical synthesis of three marketed agrochemicals from deactivated carboxylic acids.
Andrea Casagrande, Rubén Solorzano‐Rodriguez, Maria Carta, Francesco Delogu, Joris Vezzani, Allan Niidu, Evelina Colacino   +6 more
wiley   +1 more source

Chemically Modular, Nonfluorinated Polymer Adsorbents for Capturing Per‐ and Polyfluoroalkyl Substances (PFAS)

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
Nonfluorinated polymer networks for PFAS adsorption are synthesized using active ester click chemistry. Incorporating Lewis base ligands along with hydrophilic and hydrophobic co‐monomers leads to high PFOA binding efficiency. Ligand basicity and pH are found to play an important role in PFOA sorption.
Lakshay K. Dhamania, Joshua D. Moon
wiley   +1 more source

Piperazine Abuse and Psychosis: A Systematic Review of the Literature

Psychiatry International
Background: Piperazines, synthetic compounds known for their stimulant and hallucinogenic effects, have gained prominence among novel psychoactive substances (NPS) and are frequently associated with adverse psychiatric outcomes, including psychosis ...
Alessio Mosca, Stefania Chiappini, Andrea Miuli, Gianluca Mancusi, Clara Cavallotto, John M. Corkery, Livia Miotti, Mauro Pettorruso, Giovanni Martinotti, Fabrizio Schifano   +9 more
doaj   +1 more source

Enhanced Electron‐Capturing by Single‐Atomic Iron on Pyridinic N‐Deficient Carbon Drives Self‐Oxidative Degradation of Pollutants

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
Pyrolysis of FeOx/g‐C3N4 and ZIF‐8 is performed to introduce Fe single atom and pyridinic nitrogen vacancies onto N‐doped carbon. This modification enables the materials to efficiently extract electrons from ciprofloxacin (CIP) and activate dissolved oxygen. 100% of CIP was degraded within 1 min without adding any oxidant.
Jianyang Gao, Ruonan Wang, Haifeng Lin, Jun Xing, Jixiang Xu, Lei Wang   +5 more
wiley   +1 more source

Improved Incorporation of Arylglycines Into Ramoplanin Sequences via Solid‐Phase Peptide Synthesis

European Journal of Organic Chemistry, EarlyView.
The incorporation of arylglycines using solid‐phase peptide synthesis remains challenging due to the sensitivity of these residues for epimerization. Here, exploring multiple conditions for the incorporation of arylglycine residues into peptides using SPPS demonstrates how small changes to current synthesis protocols can lead to significant ...
Edward Marschall, Sam Tucker, Max J. Cryle, Julien Tailhades   +3 more
wiley   +1 more source

Iron‐Photocatalyzed Ligand‐to‐Metal Charge Transfer‐Driven Decarboxylative Giese‐Type Reactions Under Mild Conditions

European Journal of Organic Chemistry, EarlyView.
Iron‐photocatalyzed LMCT enables decarboxylative hydroalkylation of Michael acceptors (Giese‐type reaction) under mild conditions. Using tailored ligands and a sterically hindered very mild aniline base, diverse carboxylic acids efficiently couple with sensitive Michael acceptors, including maleimides.
Luca Mareen Denkler, Amrita Chaudhuri, Tak Shing Jason Ngan, Ali Dbouk, Qing Zhuo, Onisha Herath Pathirannehalage, Christopher Heinz Köhler, Shen Yen Ho, Idris Karakaya, Ala Bunescu   +9 more
wiley   +1 more source

Evaluation of Antiproliferative Activity and Molecular Modeling Studies of Some Novel Benzimidazolone-Bridged Hybrid Compounds

Pharmaceuticals
Background/Objectives: Cancer is among the leading causes of mortality worldwide. In 2022 alone, the global cancer death toll stood at 9.74 million. Projections indicate that this figure will rise to 10.4 million by 2025.
Okan Güven, Emre Menteşe, Fatih Yılmaz, Adem Güner, Mustafa Emirik, Nedime Çalışkan   +5 more
doaj   +1 more source

Stereoselective and Diastereospecific Aminosilylation and Hydrosilylation of Heterobicyclic Alkenes by Copper Catalysis Under Mild Conditions

European Journal of Organic Chemistry, EarlyView.
An efficient and straightforward methodology for the stereoselective and diastereospecific aminosilylation and hydrosilylation of heterobicyclic norbornene derivatives is introduced. The mild conditions enable the functionalization of norbornene substrates with broad functional‐group tolerance.
Daniel Kamzol, Wende Chen, Aleksander Hoffman, René Wilhelm   +3 more
wiley   +1 more source