Results 81 to 90 of about 50,209 (265)

Design, Synthesis and Anticancer Screening of Novel Benzothiazole-Piperazine-1,2,3-Triazole Hybrids

Molecules, 2018
A library of novel regioselective 1,4-di and 1,4,5-trisubstituted-1,2,3-triazole based benzothiazole-piperazine conjugates were designed and synthesized using the click synthesis approach in the presence and absence of the Cu(I) catalyst. Some of these 1,
Mohamed R. Aouad, Moataz A. Soliman, Muath O. Alharbi, Sanaa K. Bardaweel, Pramod K. Sahu, Adeeb A. Ali, Mouslim Messali, Nadjet Rezki, Yaseen A. Al-Soud   +8 more
doaj   +1 more source

Über Pyrazine und Piperazine

, 1896
ÜBER PYRAZINE UND PIPERAZINE Über Pyrazine und Piperazine ([1]) Binding ( - ) Title page ([1]) Dedication ([3]) Einleitung. ([5]) I. Teil. (8) II. Teil. (32) Lebenslauf. ( - ) Thesen. ( - ) Binding (
Brandes, Peter
core   +1 more source

Modeling of stripper configurations for CO₂ capture using aqueous piperazine [PDF]

, 2013
textThis thesis seeks to improve the economic viability of carbon capture process by reducing the energy requirement of amine scrubbing technology. High steam requirement for solvent regeneration in this technology can be reduced by improvements in the ...
Madan, Tarun
core  

Piperazine-Based CCR5 Antagonists as HIV-1 Inhibitors. II. Discovery of 1-[(2,4-Dimethyl-3-pyridinyl)carbonyl]-4- methyl-4-[3(S)-methyl-4-[1(S)-[4-(trifluoro- methyl)phenyl]ethyl]-1-piperazinyl]- piperidine N1-Oxide (Sch-350634), an Orally Bioavailable, Potent CCR5 Antagonist

, 2016
Truncation of the original piperidino-2(S)-methyl piperazine lead structure 2, from a family of muscarinic antagonists, gave compound 8 which has improved selectivity for the HIV-1 co-receptor CCR5 over muscarinic receptors.
Serena Xu (2660917), Jayaram R. Tagat (2276683), Ruo W. Steensma (2718049), Michael G. Murray (2174420), Kathleen Cox (2026282), Sue-Ing Lin (2124574), Julie M. Strizki (2718031), Dennis V. Nazareno (3014244), Bernard R. Neustadt (3014247), Lisa Wojcik (3014241), Nicole Vantuno (3014238), Bahige M. Baroudy (2718034), Stuart W. McCombie (2718040)   +12 more
core   +1 more source

Thermodynamics, Quantum and Electrochemical Studies of Corrosion of Iron by Piperazine Compounds in Sulphuric Acid

International Journal of Electrochemical Science, 2013
The corrosion inhibition of mild steel in 3.2M H2SO4 solution by 1-benzyl piperazine (C2), 1,6-di(1-benzyl piperazine-1-carboxamide)hexane (C4), bis(1-benzyl piperazine) disulfure de thiuram (C5) inhibitors has been studied by potentiodynamic ...
A. Ousslim, A. Chetouani, B. Hammouti, K. Bekkouch, S.S. Al-Deyab, A. Aouniti, A. Elidrissi   +6 more
doaj   +1 more source

A Comprehensive Study on the Synthesis, Nonlinear Optical Properties, and Biological Applications of Substituted Piperazine Derivatives [PDF]

Progress in Physics of Applied Materials
Piperazine is an important organic heterocyclic compound featuring a six-membered ring with two nitrogen atoms positioned opposite each other and four carbon atoms.
Sahaya Infant Lasalle B, Senthil Pandian Muthu, Ramasamy P   +2 more
doaj   +1 more source

4-(4-Methylphenylsulfonyl)piperazin-1-ium trifluoroacetate

Acta Crystallographica Section E, 2013
In the title salt, C11H17N2O2S+·CF3COO−, the cation is protonated at the secondary piperazine N atom. The dihedral angle between the benzene ring and the piperazine mean plane is 85.54 (10)°.
S. Sreenivasa, N. R. Mohan, T. Madhu Chakrapani Rao, P. A. Suchetan, B. S. Palakshamurthy, Vijithkumar   +5 more
doaj   +1 more source

A Sensitive Approach for the Determination of the Novel Antidepressant Vilazodone: Electrochemical Sensing Using a Boron‐Doped Diamond Electrode in Surfactant‐Containing Media [PDF]

ChemistryOpen
The combination of BRBS with Tween 20 enhanced the VLD oxidation signal at ~+0.67 V through surfactant‐assisted adsorption and preconcentration on the BDD electrode surface, resulting in improved sensitivity and signal‐to‐noise ratio. In this study, VLD was also found to undergo oxidation via the piperazine ring through a 2e−/2H+ process at the boron ...
İlvan B, Kucuk I, Sadak S, Silah H, Uslu B.   +4 more
europepmc   +2 more sources

Histamine and the mechanisms of nausea and vomiting: Translating the uncertain pharmacology of cyclizine

British Journal of Clinical Pharmacology, EarlyView.
Abstract Cyclizine is a long‐established, short‐acting drug, registered for preventing motion sickness, post‐operative nausea and vomiting (PONV) and ‘vomiting of known cause’. The latter is not defined but may include pregnancy and patients receiving palliative care, historically accepted without large, controlled trials.
Gareth J. Sanger, Paul L. R. Andrews
wiley   +1 more source

Absorption, distribution, metabolism and excretion of londamocitinib after single‐dose inhaled, intravenous and oral administration in healthy participants

British Journal of Clinical Pharmacology, EarlyView.
Aim Londamocitinib (AZD4604) is an inhaled, selective Janus kinase 1 (JAK1) inhibitor in development for asthma. This open‐label, two‐part, phase I clinical study (NCT06157255) used a radiolabelled microtracer approach to evaluate the absolute bioavailability and the absorption, distribution, metabolism and excretion (ADME) of inhaled londamocitinib ...
Camille Riff, Peter Bold, Maria Heijer, Ryan A. Bragg, Danielle Steele, Tina Jellesmark Jensen, Davinder P. S. Dosanjh, Sabrina I. Hanswijk‐Bartelds, Esther van Duijn, Elwin R. Verheij, Somasekhara Menakuru, Rod Hughes, Helena Dahlbäck   +12 more
wiley   +1 more source