Development of green purification process for piperazine-type drugs: a case study of quetiapine process development. [PDF]
Huang W, Wang Y, Liu H, Li H, Yin Q.
europepmc +1 more source
Probing skin photoallergens in reconstructed human epidermis: An EPR spin trapping investigation
We present an original proof‐of‐concept methodology to probe radical generation from allergens in contact with photoexposed skin, using electron paramagnetic resonance and spin trapping in a reconstructed human epidermis model mimicking real‐life exposure scenarios.
Yannick Port‐Lougarre +3 more
wiley +1 more source
Novel piperazine-triazole hybrids as PTP1B and alpha-amylase inhibitors: synthesis, biological evaluation and computational validation through network pharmacology, molecular docking, MD simulations, DFT and MMPBSA analysis. [PDF]
Haroon M, Kamal S, Mansha A, Zahoor AF.
europepmc +1 more source
Advances in organic UV filters for sunscreens over the past decade
Highlighted organic UV filter frameworks that have been described for sunscreens over the past decade divided into three groups: derivatives of or inspired by approved organic UV filters, natural product‐based compounds, and miscellaneous. Abstract Ultraviolet (UV) radiation is a major environmental factor in photoaging, erythema, and skin cancer ...
Gabriela Zanella Marcon +4 more
wiley +1 more source
Aminal-Linked Porous Piperazine Covalent Organic Polymers for Gold Sequestration from E-Waste with Exceptional Performance Metrics. [PDF]
Kumar S +6 more
europepmc +1 more source
Comparison of PSA and amine‐based absorption for syngas purification shows that PSA offers lower energy intensity, global warming potential, and minimum selling price, making it a more sustainable option. However, absorption achieves higher syngas purity. A GREENSCOPE‐based multi‐criteria assessment guides optimal process selection.
Magno Fonseca Santos +2 more
wiley +1 more source
Molecular Editing of Bilobalide: Regioselective C-Ring Lactam Formation. [PDF]
Wang W +5 more
europepmc +1 more source
Site‐specifically modified α‐synuclein containing DOPA or phosphorylation was prepared by ligation of a bacterially expressed N‐terminal polypeptide and a synthetic C‐terminal modified peptide. ABSTRACT α‐Synuclein (αSyn) is a major component of pathogenic Lewy bodies and Lewy neurites and is closely associated with Parkinson's disease.
Tatsuhito Matsuo +7 more
wiley +1 more source
Discovery of unprecedented prenylated indole piperazines and pyrazines through cryptic biosynthetic gene cluster heterologous expression. [PDF]
Zha Z +12 more
europepmc +1 more source
This study explores enzyme‐responsive nanoparticles for targeted antimicrobial release in inflamed oral environments. Nanoparticles formed by complexing peptides and chlorhexidine respond to human leukocyte elastase and release chlorhexidine selectively. P7 (ECAAPVCE)‐based formulations show optimal properties and stability, with antimicrobial activity
Mohammed A. Hadis +9 more
wiley +1 more source

