Results 121 to 130 of about 45,771 (255)
, 1896 ÜBER PYRAZINE UND PIPERAZINE Über Pyrazine und Piperazine ([1]) Binding ( - ) Title page ([1]) Dedication ([3]) Einleitung. ([5]) I. Teil. (8) II. Teil. (32) Lebenslauf. ( - ) Thesen. ( - ) Binding (
Brandes, Peter
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Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt
British Journal of Pharmacology, EarlyView.Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown +2 more
wiley +1 more source
Derivatives of piperazine [PDF]
, 1928 The preparation of optically active bases will prove conclusively the trihedral distribution of the valencies of trivalent nitrogen. All the aromatic derivatives of this type which have been prepared hitherto have proved to beunsatisfactory for further ...
Thorn, Vera M.
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Selective targeting of cortactin tandem repeat acetylation by human lysine deacetylases
The FEBS Journal, EarlyView.Cortactin function is regulated by acetylation at several lysine residues within its tandem repeat region. Using genetic code expansion to generate cortactin variants containing precisely defined acetylation marks, we show that HDAC6 is the primary enzyme removing these modifications, with SIRT1 and SIRT2 also acting at selected sites but with lower ...
Jan Komarek +12 more
wiley +1 more source
Pilot Plant Results with Piperazine
, 2013 Concentrated (40wt %) piperazine (PZ) with two-stage flash regeneration is an advanced second generation amine-based process for CO2 capture. Two pilot campaigns with the two-stage flash process were completed in 2011 and successfully demonstrated high ...
Walters, Matthew S. +5 more
core +1 more source
The R203W substitution drives PACS‐1 syndrome by disrupting intramolecular regulation
The FEBS Journal, EarlyView.The middle region (MR) of PACS‐1 controls engagement with specific partner proteins. This manuscript presents the structure of the Furin binding region (FBR) and how interactions with partners are regulated through the interplay between a basic patch in the FBR and an acidic cluster in the MR.
Troy C. Krzysiak +7 more
wiley +1 more source
Ethyl 4-(phenylsulfonyl)piperazine-1-carboxylate
, 2011 In the title compound, C13H18N2O4S, the piperazine ring adopts a chair conformation. The dihedral angle between the least-squares planes through the piperazine and benzene rings is 73.23 (10)°.
Hassan H. Adballah +4 more
core +1 more source
Probing skin photoallergens in reconstructed human epidermis: An EPR spin trapping investigation
Photochemistry and Photobiology, Volume 101, Issue 2, Page 275-281, March/April 2025.We present an original proof‐of‐concept methodology to probe radical generation from allergens in contact with photoexposed skin, using electron paramagnetic resonance and spin trapping in a reconstructed human epidermis model mimicking real‐life exposure scenarios.
Yannick Port‐Lougarre +3 more
wiley +1 more source
Spectrophotometric determination of piperazine with chloranil.
, 1984 Piperazine and its salts were determined by spectrophotometry by complex formation with chloranil in an aq. ethanol medium, without prior separation of the free base, and measurement of the absorbance of the complex at 382 nm. Beer's law was obeyed for 1
Abounassif +2 more
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Advances in organic UV filters for sunscreens over the past decade
Photochemistry and Photobiology, EarlyView.Highlighted organic UV filter frameworks that have been described for sunscreens over the past decade divided into three groups: derivatives of or inspired by approved organic UV filters, natural product‐based compounds, and miscellaneous. Abstract Ultraviolet (UV) radiation is a major environmental factor in photoaging, erythema, and skin cancer ...
Gabriela Zanella Marcon +4 more
wiley +1 more source