Results 141 to 150 of about 37,749 (227)

Synthetic Ligands of Myeloid C‐Type Lectin Receptors

ChemBioChem, Volume 27, Issue 13, 14 July 2026.
Binding of ligands to C‐type lectin receptors (CLRs) on myeloid cells can lead to an array of cellular responses. Exploitation of these receptors for therapeutic purposes requires high‐affinity ligands. This review surveys the diversity of synthetic ligands of myeloid CLRs in the context of binding, signaling, and downstream effects, as well as ...
James Suri, Bernd Lepenies
wiley   +1 more source

Levofloxacin-loaded surfactant nanocarriers: a computational study. [PDF]

Nanoscale Adv
Sharoyan A, Hakobyan V, Melkonyan H, Ishkhanyan H, Poghosyan AH, Parsadanyan MA, Antonyan AP, Vardevanyan PO.   +7 more
europepmc   +1 more source

PIPERAZINE [PDF]

Chemical & Engineering News Archive, 1957
openaire   +1 more source

Hit‐To‐Lead Optimization of a Pyridylpiperazine Class Against Malaria: Pharmacokinetic Profile and In Vivo Efficacy of Optimized Compounds

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
Chemical optimization of a novel pyridylpiperazine class yields two promising antimalarial candidates with an exceptional balance of metabolic stability and solubility. These optimized leads significantly protect mice from cerebral malaria, reducing parasitic load by up to 91.7%.
Douglas Davison da Silva Oliveira, Duarte Eduardo Pereira, Rafael Consolin Chelucci, Simone Michelan, Júlia Maria Fernandes Pituba, Adriano D. Andricopulo, Leonardo L. G. Ferreira, Neide Maria Silva, Celso de Oliveira Rezende Júnior   +8 more
wiley   +1 more source

Structure-guided optimisation of fenofibrate-derived oxidative phosphorylation inhibitors to modify tumour hypoxia. [PDF]

RSC Med Chem
Holt-Martyn JP, Machado N, Coates JTT, Puliyadi R, Ashton T, Traynor E, Aslam S, Wise TK, Rodriguez-Berriguete G, Schofield CJ, Higgins GS.   +10 more
europepmc   +1 more source

Design and Synthesis of Novel Imidazo[4,5‐c]pyridine Derivatives, Evaluation of Their Activity Against Hepatitis C Virus and In Silico Prediction of Their Binding Mode to NS4B Protein

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
A series of 18 novel imidazo[4,5‐c]pyridines was synthesized, and their anti‐HCV activity was evaluated. Compound 30b was identified as the most promising one, with EC50 = 6.61 µM. Molecular docking studies indicated the NS4B protein of the HCV as a potential target of these derivatives.
Eftychia Karampella, George Mpekoulis, Maria Georgiou, Iris Kolida, Katerina I. Kalliampakou, Eirini P. Kollia, Eleni V. Mikropoulou, Maria Halabalaki, Christos T. Chasapis, Niki Vassilaki, Nikolaos Lougiakis   +10 more
wiley   +1 more source

CS-[BiC-PiC]-NiCl₄: a green and effective heterogeneous catalyst for one-pot synthesis of 2,3-dihydroquinazolin-4(1<i>H</i>)-one derivatives. [PDF]

RSC Adv
Seyedi N, Mousapour M, Rizehbandi M, Shirini F.   +3 more
europepmc   +1 more source

Long-cycling organic flow batteries enabled by electronic-spatial synergistic modulation. [PDF]

Sci Adv
Wang T, Xia Y, Gao C, Huang T, Zhao Z, Chen M, Yang M, Cui M, Ding Y.   +8 more
europepmc   +1 more source

Click chemistry of phenyl 1,2,3-triazole-2-pyridylpiperazine hybrids: synthesis, targeted anticancer activity, molecular modeling and computational studies. [PDF]

RSC Adv
El Malah T, El-Rashedy AA.
europepmc   +1 more source

Design, Synthesis, and Protective Activity against Doxorubicin-Induced Cardiotoxicity of Novel Water-Soluble Small-Molecule GPx Mimics. [PDF]

ACS Med Chem Lett
Yu Z, Shi W, Qian Z, Mei X, Huang X, Chen X, Wang W, Zhang T, Chen X, Li Z, Zheng C.   +10 more
europepmc   +1 more source