Results 111 to 120 of about 37,749 (227)

Discovery of TYR inhibitors from de novo molecular generation to dual-track lead optimization: "Competition" between AI and chemists. [PDF]

Sci Adv
Sun Y, Wang J, Chen W, Jiang X, Wang S, Zhi J, Li F, Feng M, Niu X, Ju B, Guo J, Bai R.   +11 more
europepmc   +1 more source

Overcoming Radiation Resistance: Ferroptosis Induction to Sensitize Solid Tumors to Radiation Therapy

Cancer Medicine, Volume 15, Issue 8, August 2026.
ABSTRACT Radiation therapy (RT) is a mainstay of treatment for a myriad of cancers, often utilized for tumors that are unable to be resected, as well as an adjunct to surgery and chemotherapy. Unfortunately, many cancers are resistant to RT‐induced damage and subsequent cell death.
Joseph Carmicheal, Caden M. Fritson, Alexandra Seas, Heidi Vieira, Surinder K. Batra   +4 more
wiley   +1 more source

Recent advances in piperine and its derivatives as potential anticancer agents. [PDF]

RSC Med Chem
Yu QH, Liu Z, Liu J, Bai LP.
europepmc   +1 more source

Structure‐Based Design, Synthesis, and Biological Evaluation of Oxadiazole–Morpholine Hybrids as Potent PARP‐1 Inhibitors Inducing Apoptosis in Breast Cancer Cells

Drug Development Research, Volume 87, Issue 5, August 2026.
ABSTRACT Poly(ADP‐ribose) polymerase‐1 (PARP‐1) plays a central role in the repair of DNA single‐strand breaks and represents an established therapeutic target in cancer treatment. In this study, a series of novel oxadiazole–morpholine hybrid compounds was designed and synthesized using a structure‐based drug design approach to target the catalytic ...
Nader R. Albujuq, Khaled M. Darwish, Sherif Ashraf Fahmy, Buthaina Hussein, Ghada G. Kayed, Musa A. Said, Mohamed S. Nafie   +6 more
wiley   +1 more source

Discovery of a Potent and Selective MAO‐B Inhibitor From a Donepezil‐Linked Chalcone Library With Promising Antiparkinsonian Activity

Drug Development Research, Volume 87, Issue 5, August 2026.
ABSTRACT A focused library of 19 donepezil‐linked chalcones (DLCs) was efficiently synthesised through microwave‐assisted Claisen‐Schmidt condensation and subsequently profiled for their inhibitory activities against cholinesterases (AChE and BuChE) as well as monoamine oxidases (MAO‐A and MAO‐B).
Azize Kirac‐Aydin, Bishnu Prasad Pandey, Satyajit Mohanty, Rupsa Mondal, Abanish Biswas, Ashok Kumar Pattnaik, Subodh Mondal, Vinay N. Basavanakatti, Nilüfer Bayrak, Venkatesan Jayaprakash, Hoon Kim, Amaç Fatih TuYuN   +11 more
wiley   +1 more source

Design, synthesis and biological evaluation of tacrine-sulphonamide hybrids as a potent acetylcholinesterase inhibitor. [PDF]

RSC Adv
Reddy MM, Reddy EK, J A, Dev RR, Kadambari VSN, Anwar S.   +5 more
europepmc   +1 more source

Pre‐Infection COVID‐19 Vaccination and Long‐Term Cardiovascular Outcomes in Adults Without Preexisting Cardiovascular Disease: A Retrospective Cohort Study

Health Science Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background Long‐term cardiovascular complications after COVID‐19 are increasingly recognized, yet the protective effect of pre‐infection vaccination in individuals without prior cardiovascular disease (CVD) remains unclear. This study examined the association between COVID‐19 vaccination and major cardiovascular and related outcomes up to 3 ...
Abdul Qadeer, Muneeb Khawar, Michele Fouad, Samiksha Jain, Prutha Pathak, Awon Muhammad, Anu Radha Twayana, Kamel Ikbariah, Najam Gohar, Mueed Chaudhary, Elham Shenawa, Mirza Muhammad Hadeed Khawar   +11 more
wiley   +1 more source

Targeting Activin Receptor-like Kinase 2 Using Heterobifunctional Protein Degraders. [PDF]

J Med Chem
Webb DT, Jones KL, Macabuag N, Bago R, Betts J, Bhattacharyya S, Clifton S, Tinson RAJ, Achara C, Gilbert S, Howell S, Drewry DH, Rogers R, Jones C, Ferguson KR, Bullock AN, Lindsay DM, Kerr WJ, Esmieu W.   +18 more
europepmc   +1 more source

On the Assembly of Actin Polymerization‐Powered Motors

Macromolecular Rapid Communications, Volume 47, Issue 15, 4 August 2026.
Actin polymerization‐powered motors have the highest speed when the actin recruiting‐polymerizing proteins are immobilized in polymer brushes on their surface. These motors orbit around larger tracer particles at pH above the isoelectric point of ActA but dock onto the tracer particles’ surface at lower pH. ABSTRACT Nano‐ and micromotors are a class of
Miguel A. Ramos Docampo, Cathrine Abild Meyer, Brigitte Städler   +2 more
wiley   +1 more source

Piperazine-Thiourea Hybrids as Novel Antiplatelet Agents Targeting COX-1: Synthesis, <i>in Vitro</i>, and <i>in Silico</i> Evaluation. [PDF]

ACS Omega
Pereira GRC, Viana GM, Huber MB, Rodrigues PS, Gonçalves ARSP, Sathler PC, Rodrigues CR, Abrahim-Vieira BA, Cabral LM.   +8 more
europepmc   +1 more source