Results 241 to 250 of about 39,960 (300)

Synthesis and discovery of triazolo-pyridazine-6-yl-substituted piperazines as effective anti-diabetic drugs; evaluated over dipeptidyl peptidase-4 inhibition mechanism and insulinotropic activities.

European journal of medicinal chemistry, 2019
A family of 12 triazolo-pyridazine-6-yl-substituted piperazines (5a-l) was synthesized and evaluated for their Dipeptidyl peptidase-4 (DPP-4) inhibition potentials in order to develop them as anti-diabetic medications.
B. Bindu, S. Vijayalakshmi, A. Manikandan   +2 more
semanticscholar   +1 more source

Synthesis of N-Pyrrolyl(furanyl)-Substituted Piperazines, 1,4-Dizepanes, and 1,4-Diazocanes.

Journal of Organic Chemistry, 2019
The synthetic potential of 5-bromo-1,1,1-trifluoro-4-methoxypent-3-en-2-one toward the catalyst-free synthesis of N-pyrrolyl(furanyl)-piperazines, 1,4-diazepanes, and 1,4-diazocanes through a telescoped protocol is reported.
Mateus Mittersteiner, Valquiria P. Andrade, Lucimara L. Zachow, C. Frizzo, H. Bonacorso, M. Martins, N. Zanatta   +6 more
semanticscholar   +1 more source

High Catalytic Activity of Pd Nanoparticles Synthesized from Green Alga Chlorella vulgaris in Buchwald-hartwig Synthesis of N-Aryl Piperazines

, 2019
The N-aryl piperazines are an important component of many drug products used for the treatment of malaria, depression, anxiety and Parkinson diseases. Buchwald-Hartwig amination is the latest and well-known reaction for Pd catalyzed direct synthesis of
V. Mishra, Anju Arya, T. Chundawat
semanticscholar   +1 more source

Discovery and optimization of novel piperazines as potent inhibitors of fatty acid synthase (FASN).

Bioorganic & Medicinal Chemistry Letters, 2019
The discovery, structure-activity relationships, and optimization of a novel class of fatty acid synthase (FASN) inhibitors is reported. High throughput screening identified a series of substituted piperazines with structural features that enable ...
Matthew W. Martin, D. Lancia, Hongbin Li, Shawn E R Schiller, A. Toms, Zhongguo Wang, K. Bair, Jennifer Castro, S. Fessler, D. Gotur, Stephen E. Hubbs, G. Kauffman, Mark T. Kershaw, G. P. Luke, Crystal L. McKinnon, Lili Yao, W. Lu, David S. Millan   +17 more
semanticscholar   +1 more source

Enantioselective Synthesis of α‐Secondary and α‐Tertiary Piperazin‐2‐ones and Piperazines by Catalytic Asymmetric Allylic Alkylation

Angewandte Chemie - International Edition, 2015
Brian M Stoltz
exaly   +2 more sources

Selective, Catalytic, and Dual C(sp3)-H Oxidation of Piperazines and Morpholines under Transition-Metal-Free Conditions.

Journal of Organic Chemistry, 2018
By using cheap and innocuous reagents, such as NaClO2, NaOCl, and catalytic amounts of TEMPO, a new environmentally friendly protocol for the selective and catalytic TEMPO C(sp3)-H oxidation of piperazines and morpholines to 2,3-diketopiperazines (2,3 ...
Delfino Chamorro‐Arenas, Urbano Osorio-Nieto, L. Quintero, L. Hernandez-Garcia, Fernando Sartillo‐Piscil   +4 more
semanticscholar   +1 more source

Discovery and optimization of heteroaryl piperazines as potent and selective PI3Kδ inhibitors.

Bioorganic & Medicinal Chemistry Letters, 2019
A high-throughput screening (HTS) campaign identified a class of heteroaryl piperazines with excellent baseline affinity and selectivity for phosphoinositide 3-kinase δ (PI3Kδ) over closely related isoforms. Rapid evaluation and optimization of structure-
Hua Zhou, Meredeth A Mcgowan, Kate Lipford, M. Christopher, X. Fradera, D. Witter, C. Lesburg, Chaomin Li, J. Methot, J. Lampe, Abdelghani Achab, Lynsey Shaffer, P. Goldenblatt, Sanjiv J. Shah, A. Bass, Gottfried K. Schroeder, Dapeng Chen, Haoyu Zeng, M. Augustin, J. Katz   +19 more
semanticscholar   +1 more source

Stereospecific Synthesis of Highly Substituted Piperazines via an One-Pot Three Component Ring-Opening Cyclization from N-Activated Aziridines, Anilines, and Propargyl Carbonates.

Journal of Organic Chemistry, 2018
A simple and efficient one-pot three-component synthetic route to highly substituted and functionalizable piperazines in high yields with excellent stereoselectivity (de, ee >99%) is reported.
N. Chauhan, Sajan Pradhan, M. Ghorai
semanticscholar   +1 more source

Synthesis and antitubercular activity of 1,2,4-trisubstitued piperazines

Bioorganic and Medicinal Chemistry Letters, 2016
Adel Nefzi, Kyle H Rohde
exaly   +2 more sources

Novel chiral N,N′-dimethyl-1,4-piperazines with metal binding abilities

Tetrahedron, 2015
Christopher Bérubé, Xavier Barbeau, Normand Voyer   +2 more
exaly   +2 more sources