Results 231 to 240 of about 39,960 (300)

Discovery, bioactivity and biosynthesis of fungal piperazines.

Natural product reports (Print), 2022
Covering: up to the end of July, 2022Fungi are prolific producers of piperazine alkaloids, which have been shown to exhibit an array of remarkable biological activities.
Rui Wang, Andrew M. Piggott, Y. Chooi, Hang Li   +3 more
semanticscholar   +1 more source

Bis(vinylsulfonyl)piperazines as efficient linkers for highly homogeneous antibody-drug conjugates

European Journal of Medicinal Chemistry, 2020
Disulfide re-bridging strategy has demonstrated significant advantages in the construction of homogeneous antibody drug conjugates (ADCs). However, a major issue that disulfide scrambling at the hinge region of antibody leads to the formation of "half ...
Rong Huang, Hongli Chen, Biao Jiang
exaly   +2 more sources

Rapid and sensitive detection of nerve agent mimics by meso-substituted BODIPY piperazines as fluorescent chemosensors

, 2021
Chemosensors are rapid, portable and reliable methods for the field detection of chemical warfare agents. In this work, three meso-substituted BODIPY piperazines, BPA-1, BPA-2 and BPA-3, have been prepared for rapid and sensitive detections of nerve ...
Fentahun Wondu Dagnaw, Yi Cai, Qin-Hua Song   +2 more
semanticscholar   +1 more source

Chrysosporazines F-M: P-Glycoprotein Inhibitory Phenylpropanoid Piperazines from an Australian Marine Fish Derived Fungus, Chrysosporium sp. CMB-F294.

Journal of Natural Products, 2020
Chemical analysis of the fungus Chrysosporium sp. CMB-F294 isolated from the gastrointestinal tract of a market-purchased specimen of Mugil mullet yielded eight new alkaloids, belonging to a rare class of phenylpropanoid piperazines. Chrysosporazines F-M
Osama G. Mohamed, A. Salim, Zeinab G. Khalil, Ahmed H. Elbanna, P. Bernhardt, R. Capon   +5 more
semanticscholar   +1 more source

Biocatalytic Access to Piperazines from Diamines and Dicarbonyls

ACS Catalysis, 2018
Bettina M Nestl
exaly   +2 more sources

Synthesis and biological evaluation of some new mono Mannich bases with piperazines as possible anticancer agents and carbonic anhydrase inhibitors.

Bioorganic chemistry (Print), 2019
New mono Mannich bases, (2-(4-hydroxy-3-((4-substituephenylpiperazin-1-yl)methyl)benzylidene)-2,3-dihydro-1H-inden-1-one), were prepared to evaluate their cytotoxic/anticancer properties and also their inhibitory effects on human carbonic anhydrase I and
M. Tuğrak, H. Gul, K. Bandow, H. Sakagami, I. Gulcin, Yusuf Ozkay, C. Supuran   +6 more
semanticscholar   +1 more source

Lowering Lipophilicity by Adding Carbon: One-Carbon Bridges of Morpholines and Piperazines.

Journal of Medicinal Chemistry, 2018
In this article, we report our investigation of a phenomenon by which bridging morpholines across the ring with one-carbon tethers leads to a counterintuitive reduction in lipophilicity.
S. Degorce, M. Bodnarchuk, I. Cumming, James S. Scott   +3 more
semanticscholar   +1 more source

The medicinal chemistry of piperazines: A review

Chemical Biology and Drug Design
The versatile basic structure of piperazine allows for the development and production of newer bioactive molecules that can be used to treat a wide range of diseases.
M. Faizan, Rajnish Kumar, Avijit Mazumder, Salahuddin, Neelima Kukreti, Arvind Kumar, M. Chaitanya   +6 more
semanticscholar   +1 more source

Chrysosporazines A-E: P-Glycoprotein Inhibitory Piperazines from an Australian Marine Fish Gastrointestinal Tract-Derived Fungus, Chrysosporium sp. CMB-F214.

Organic Letters, 2019
Chemical analysis of Chrysosporium sp. CMB-F214, yielded five new piperazines, chrysosporazines A-E (1-5), with structures assigned by spectroscopic and X-ray analyses and biosynthetic considerations.
Ahmed H. Elbanna, Zeinab G. Khalil, P. Bernhardt, R. Capon   +3 more
semanticscholar   +1 more source

New phenolic Mannich bases with piperazines and their bioactivities.

Bioorganic chemistry (Print), 2019
In this study, new Mannich bases, 2-(4-hydroxy-3-methoxy-5-((substitutedpiperazin-1-yl)methyl)benzylidene)-2,3-dihydro-1H-inden-1-one (1, 2, 4, 5, 8), 2-(3-((substituted)piperazin-1-yl)methyl)-4-hydroxy-5-methoxybenzylidene)-2,3-dihydro-1H-inden-1-one (3,
H. Gul, M. Tuğrak, M. Gul, Sertac Mazlumoglu, H. Sakagami, I. Gulcin, C. Supuran   +6 more
semanticscholar   +1 more source