Results 211 to 220 of about 37,689 (286)

Direct synthesis of piperazines containing dithiocarbamate derivatives via DABCO bond cleavage

Tetrahedron Letters, 2020
DABCO bond cleavage with dithiocarbamic acid salts was applied as a direct synthetic route for the preparation of a novel category of piperazines containing dithiocarbamate functional group.
Seyyed Emad Hooshmand, Azim Ziyaei Halimehjani   +1 more
exaly   +3 more sources

Synthesis and antitubercular activity of 1,2,4-trisubstitued piperazines

Bioorganic and Medicinal Chemistry Letters, 2016
Parallel solid phase synthesis offers a unique opportunity for the synthesis and screening of large numbers of compounds and significantly enhances the prospect of finding new leads.
Kyle H Rohde, Adel Nefzi
exaly   +3 more sources

Iridium-Catalyzed Regio- and Diastereoselective Synthesis of C-Substituted Piperazines [PDF]

ACS Catalysis, 2023
Piperazine rings are essential motifs frequently found in commercial drugs. However, synthetic methodologies are mainly limited to N-substituted piperazines, preventing structural diversity.
Luis Tarifa, M Pilar Del Rio, JOSÉ A Lopez   +2 more
exaly   +2 more sources

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Discovery of 1,2,3-triazole incorporated indole-piperazines as potent antitubercular agents: Design, synthesis, in vitro biological evaluation, molecular docking and ADME studies.

Bioorganic & Medicinal Chemistry, 2023
In this report, a library consisting of three sets of indole-piperazine derivatives was designed through the molecular hybridization approach. In total, fifty new hybrid compounds (T1-T50) were synthesized and screened for antitubercular activity against
Rajkumar Reddyrajula, Umadevi Etikyala, V. Manga, Udaya Kumar Dalimba   +3 more
semanticscholar   +1 more source

Discovery, bioactivity and biosynthesis of fungal piperazines.

Natural product reports (Print), 2022
Covering: up to the end of July, 2022Fungi are prolific producers of piperazine alkaloids, which have been shown to exhibit an array of remarkable biological activities.
Rui Wang, Andrew M. Piggott, Y. Chooi, Hang Li   +3 more
semanticscholar   +1 more source

Rapid and sensitive detection of nerve agent mimics by meso-substituted BODIPY piperazines as fluorescent chemosensors

, 2021
Chemosensors are rapid, portable and reliable methods for the field detection of chemical warfare agents. In this work, three meso-substituted BODIPY piperazines, BPA-1, BPA-2 and BPA-3, have been prepared for rapid and sensitive detections of nerve ...
Fentahun Wondu Dagnaw, Yi Cai, Qin-Hua Song   +2 more
semanticscholar   +1 more source

Bis(vinylsulfonyl)piperazines as efficient linkers for highly homogeneous antibody-drug conjugates.

European journal of medicinal chemistry, 2020
Disulfide re-bridging strategy has demonstrated significant advantages in the construction of homogeneous antibody drug conjugates (ADCs). However, a major issue that disulfide scrambling at the hinge region of antibody leads to the formation of "half ...
Rong Huang, Yao Sheng, Ding Wei, Jianghui Yu, Hongli Chen, B. Jiang   +5 more
semanticscholar   +1 more source

Chrysosporazines F-M: P-Glycoprotein Inhibitory Phenylpropanoid Piperazines from an Australian Marine Fish Derived Fungus, Chrysosporium sp. CMB-F294.

Journal of Natural Products, 2020
Chemical analysis of the fungus Chrysosporium sp. CMB-F294 isolated from the gastrointestinal tract of a market-purchased specimen of Mugil mullet yielded eight new alkaloids, belonging to a rare class of phenylpropanoid piperazines. Chrysosporazines F-M
Osama G. Mohamed, Angela A. Salim, Zeinab G. Khalil, Ahmed H. Elbanna, P. Bernhardt, R. Capon   +5 more
semanticscholar   +1 more source

Synthesis and biological evaluation of some new mono Mannich bases with piperazines as possible anticancer agents and carbonic anhydrase inhibitors.

Bioorganic chemistry (Print), 2019
New mono Mannich bases, (2-(4-hydroxy-3-((4-substituephenylpiperazin-1-yl)methyl)benzylidene)-2,3-dihydro-1H-inden-1-one), were prepared to evaluate their cytotoxic/anticancer properties and also their inhibitory effects on human carbonic anhydrase I and
M. Tuğrak, H. Gul, K. Bandow, H. Sakagami, I. Gulcin, Yusuf Ozkay, C. Supuran   +6 more
semanticscholar   +1 more source

The medicinal chemistry of piperazines: A review

Chemical Biology and Drug Design
The versatile basic structure of piperazine allows for the development and production of newer bioactive molecules that can be used to treat a wide range of diseases.
M. Faizan, Rajnish Kumar, Avijit Mazumder, Salahuddin, Neelima Kukreti, Arvind Kumar, M. Chaitanya   +6 more
semanticscholar   +1 more source