Results 251 to 260 of about 37,707 (289)

Discovery of Rezatapopt (PC14586), a First-in-Class, Small-Molecule Reactivator of p53 Y220C Mutant in Development. [PDF]

ACS Med Chem Lett
Vu BT, Dominique R, Fahr BJ, Li HH, Fry DC, Xu L, Yang H, Puzio-Kuter A, Good A, Liu B, Huang KS, Tanaka N, Davis TW, Dumble ML.   +13 more
europepmc   +1 more source

Investigation of Thiazolidine‐2,4‐Dione Derivatives as Acetylcholinesterase Inhibitors: Synthesis, In Vitro Biological Activities and In Silico Studies

ChemistryOpen, EarlyView.
Thiazolidin‐2,4‐dion derivatives were synthesized and evaluated for drug‐likeness, BBB permeability, and ADMET properties. Docking studies revealed that all derivatives (CHT1‐5) had good AChE inhibition, although CHT1 was the most effective and showed strong antioxidant activity in vitro.
Hanane Naeimi, Maryam Taheri, Hossein Ghafouri, Asadollah Mohammadi   +3 more
wiley   +1 more source

Enantioselective Organocatalytic Addition of 1,3-Dicarbonyl Compounds to β-Arylvinyl Triflones. [PDF]

Org Lett
Kopyt M, Dudziński J, Barbasiewicz M, Kwiatkowski P.   +3 more
europepmc   +1 more source

Synthesis and Evaluation of Antitumor and Anti-Angiogenesis Activity of Pyrone- or Pyridone-Embedded Analogs of Cortistatin A. [PDF]

Mar Drugs
Fujimoto Y, Mizuno K, Nakamura Y, Arai M, Kotoku N.   +4 more
europepmc   +1 more source

Synthesis and Evaluation of Benzylic ¹⁸F-Labeled <i>N</i>-Biphenylalkynyl Nipecotic Acid Derivatives for PET Imaging of GABA Transporter 1. [PDF]

ACS Chem Neurosci
Knippenberg N, Bauwens M, Florea A, Rudi S, Schijns O, Hoogland G, Ornelis V, Mohren R, Vandenbosch M, Mottaghy FM, Cleij TJ, Eersels K, van Grinsven B, Diliën H.   +13 more
europepmc   +1 more source

Design, synthesis, in vitro and in silico studies of novel piperidine derived thiosemicarbazones as inhibitors of dihydrofolate reductase. [PDF]

Sci Rep
Aftab H, Ullah S, Khan A, Al-Rashida M, Islam T, Dahlous KA, Mohammad S, Kashtoh H, Al-Harrasi A, Shafiq Z.   +9 more
europepmc   +1 more source

Inhibition by 4-(4-Bromo-2-oxo-3<i>H</i>-benzimidazol-1-yl)-<i>N</i>-(4-iodophenyl)piperidine-1-carboxamide (TH5487) of the Activity of Human 8-Oxoguanine DNA Glycosylase-1 (OGG1) for the Excision of 2,6-Diamino-4-hydroxy-5-formamidopyrimidine, 4,6-Diamino-5-formamidopyrimidine, and 8-Oxoguanine from Oxidatively Damaged DNA. [PDF]

Biochemistry
Jaruga P, Kant M, Luzadder MM, Lloyd RS, Boldogh I, Dizdaroglu M.   +5 more
europepmc   +1 more source

Mefloquine reduces the bacterial membrane fluidity of <i>Acinetobacter baumannii</i> and distorts the bacterial membrane when combined with polymyxin B. [PDF]

mBio
Tharmalingam N, Jayanthan HS, Port J, Rossatto FCP, Mylonakis E.   +4 more
europepmc   +1 more source

Synthesis of Piperidines [PDF]

ChemInform, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
openaire   +2 more sources