Results 141 to 150 of about 25,392 (338)

Diphenylsulfone muscarinic antagonists: piperidine derivatives with high m2 selectivity and improved potency

, 2000
William Billard, Herbert Binch, Kristen Bratzler, Lian-Yong Chen, Gordon Crosby, Ruth A. Duffy, Sundeep Dugar, Jean E. Lachowicz, Robert McQuade, Pradeep Pushpavanam, Vilma Ruperto, Lisa A. Taylor, John W. Clader   +12 more
openalex   +1 more source

Piperidines [PDF]

Chemical & Engineering News Archive, 1977
openaire   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Flecainide binding dynamics in voltage‐gated sodium channels: A comparative isoform analysis of the state‐dependent block

British Journal of Pharmacology, EarlyView.
Background and Purpose Local anaesthetics and class I anti‐arrhythmic drugs block voltage‐gated Na+ channels, but the molecular basis for the isoform differences in drug sensitivity remains unclear. Understanding these mechanisms is essential for optimizing therapeutic efficacy and safety.
Tatsuo Munakata, Etsuko Kumada, Nao Katayama, Hiroki Nakagawa, Akihiko Sunami   +4 more
wiley   +1 more source

A STUDY OF COMPLEXES OF BLUE PEROXYCHROMIC ACID WlTH PYRIDINE AND PIPERIDINE

, 1957
Ram Chandra
openalex   +1 more source

Adaptation of DETECT for Use in Home‐Based Primary Care: Clinician Perspectives

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Background Elder mistreatment (EM) is pervasive yet under‐identified. The Detection of Elder abuse Through Emergency Care Technicians (DETECT) tool was developed to improve EM identification and reporting among emergency medical technicians. This study explores clinician perspectives on adapting DETECT for use in home‐based primary care (HBPC).
Kristin Lees Haggerty, Randi Campetti, Olanike Ojelabi, Jason Burnett, Melvin Livingston, Carolyn Pickering, Rania Abdelkhaleq, Faith D. Atai, Thomas K. M. Cudjoe, Deborah G. Freeland, Julia Hiner, Maria Yefimova, Brad Cannell   +12 more
wiley   +1 more source

Modelling of Anti-HIV-1 Activity of Piperidine-4-carboxamide CCR5 Antagonist: Role of Structural Manipulation

, 2018
Amit Kumar Tiwari, Naveen Agrawal, Mayank Thakur, G. Nagendrappa, Anuradha Thakur   +4 more
openalex   +1 more source

Designing chemical systems for precision deuteration of medicinal building blocks

Nature Communications
Methods are lacking that can prepare deuterium-enriched building blocks, in the full range of deuterium substitution patterns at the isotopic purity levels demanded by pharmaceutical use.
Jonathan D. Dabbs, Caleb C. Taylor, Martin S. Holdren, Sarah E. Brewster, Brian T. Quillin, Alvin Q. Meng, Diane A. Dickie, Brooks H. Pate, W. Dean Harman   +8 more
doaj   +1 more source

Synthesis of a novel analogue of DPP-4 inhibitor Alogliptin: Introduction of a spirocyclic moiety on the piperidine ring [PDF]

, 2010
Arumugam Kodimuthali, Padala Lakshmi Prasunamba, Manojit Pal   +2 more
openalex   +1 more source

Piperidines [PDF]

Chemical & Engineering News Archive, 1978
openaire   +1 more source