Results 121 to 130 of about 11,531 (247)

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

Small‐Molecule Kinase Inhibitors Modulating Circadian Rhythms

Medicinal Research Reviews, EarlyView.
ABSTRACT The circadian clock mechanism generates 24‐h rhythms crucial for regulating various physiological processes, and its dysregulation has been implicated in numerous diseases. In cells, the circadian clock operates through a transcriptional‐translational feedback loop, where phosphorylation plays a pivotal role in maintaining accurate circadian ...
Irene Castellino, Manuela Bartolini, Rudolf Andrys, Kamil Musilek   +3 more
wiley   +1 more source

Selective <i>endo</i>-Cyclic α-Functionalization of Saturated <i>N</i>-Alkyl Piperidines. [PDF]

J Org Chem
Phillips RC, Chu JCK, Rafaniello AA, Gaunt MJ.   +3 more
europepmc   +1 more source

Degradation of Crystalline Si‐Based Solar Modules With Varying Material Combinations—Part I: Encapsulant Degradation

Progress in Photovoltaics: Research and Applications, EarlyView.
This work deals with the degradation of solar modules with varying material combinations under accelerated aging conditions. By in situ moisture measurements and simulations of oxygen ingress, the consumption of stabilizing additives and polymer degradation can be correlated spatially resolved with the penetrating stressors.
Robert Heidrich, Oscar Lacroix‐Andrivet, Nikola Babić, Lasse Baldauf, Julia Rendon, Marko Jankovec, Marko Topič, Camille Bainier, Anton Mordvinkin, Hervé Vezin, Simon Pondaven, Ralph Gottschalg   +11 more
wiley   +1 more source

Cooperative Brønsted Acid and Photo-Promoted Stereoselective Synthesis of Substituted Piperidones. [PDF]

Angew Chem Int Ed Engl
Peng Q, Mukherjee P, Suresh A, Hwang M, Gutierrez O, Scheidt KA.   +5 more
europepmc   +1 more source

The continuing significance of chiral agrochemicals

Pest Management Science, Volume 81, Issue 4, Page 1697-1716, April 2025.
In the time frame 2018–2023, around 43% of the 35 chiral agrochemicals introduced to the market (herbicides, fungicides, insecticides, acaricides, and nematicides) contain one or more stereogenic centers in the molecule, and almost 69% of them have been marketed as racemic mixtures of enantiomers or stereoisomers.
Peter Jeschke
wiley   +1 more source

Identification and Evaluation of Dibasic Piperidines as Cell Wall Inhibitors against <i>Mycobacterium tuberculosis</i>. [PDF]

ACS Infect Dis
Naylor C, Prosser G, Bayliss T, Berle LF, Wallach JB, Kim H, Aguilera Olvera R, Thompson S, Ioerger TR, Simpson L, Casanueva R, Guijarro-Lopez L, Read KD, Wyatt PG, Schnappinger D, Barry CE, Green SR, Boshoff HIM, Cleghorn LAT.   +18 more
europepmc   +1 more source

Porous Organic Polymers: From Molecular Design to Scalable Technologies

Small, EarlyView.
This review introduces porous organic polymers (POPs) for a wide range of applications, including energy storage, gas adsorption, catalysts, adsorbents, biomedical applications, sensors, and other exciting fields, and critically analyzes the synthesis and modification, and how structural topology influences the composites' architecture of POPs, along ...
Hossein Mashhadimoslem, Hadi Shayesteh, Simindokht Zarei‐Shokat, Rokhsareh Bakhtiari, Sheyda Abedi‐Banaei, Zahra Sheikhlouiharzand, Parnia Mohebimanesh, Seyed Mohammad Amin Ojagh, Bahareh Bakhtiari, Ali Maleki, Theo G. M. van de Ven, Sohrab Zendehboudi, Ali Elkamel   +12 more
wiley   +1 more source

Potassium Bisulfite's Role in Developing a Robust Platform for Enantioenriched <i>N</i>-Alkylpyridinium Salts as Piperidine Precursors. [PDF]

J Am Chem Soc
Selingo JD, King JR, Pio B, Neel AJ, Lam YH, Paton RS, Maddess ML, McNally A.   +7 more
europepmc   +1 more source

Active pH Modulation by Proton Channel‐Peptide Nucleic Acid Complex for Effective siRNA Endosomal Escape

Small, EarlyView.
A bioinspired siRNA nanocarrier is engineered by integrating an influenza A M2 proton channel with siRNA through a peptide nucleic acid linker on liposome surfaces. Active proton transport amplifies osmotic stress within endosomes, triggering membrane rupture and cytosolic release.
Seongmin Ga, Nam Hyeong Kim, Si Yeon Ryu, Kyeonghyun Kim, Eun Sung Kang, Hayeon Bae, Seungmin Ryu, Suhyeon Kim, Yeontae Jang, Bok‐Soo Lee, Jiyoung Nam, Minah Suh, Jaecheol Lee, Seung‐gu Kang, Jaekyung Hyun, Huong T. Kratochvil, Yong Ho Kim   +16 more
wiley   +1 more source