Results 151 to 160 of about 11,531 (247)

A covalent peptide engager approach to equip immunotherapeutic monoclonal and pan IgG serum antibodies with new tumour‐targeting function

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Site‐specific antibody modification is a useful chemical strategy to elaborate antibody therapeutic function. Conventional lysine‐ or cysteine‐based conjugation methods generate heterogeneous products, while protein engineering approaches are resource‐intensive.
Karolina Krygier, Sandra Szu‐Wei Hwang, Anthony F. Rullo   +2 more
wiley   +1 more source

Transaminase-Triggered Cascades for the Synthesis and Dynamic Kinetic Resolution of Chiral N-Heterocycles. [PDF]

Angew Chem Int Ed Engl
O'Connell A, Haarr MB, Ryan J, Xu X, Martin A, Smith SN, Elghobashi-Meinhardt N, Fleming P, Maciá B, Caprio V, O'Reilly E.   +10 more
europepmc   +1 more source

Comprehensive in vitro profiling of traditional and emerging stimulants at monoamine transporters and the 5‐HT2A receptor

British Journal of Pharmacology, EarlyView.
A pharmacological profiling of 58 synthetic stimulants of various classes at dopamine, norepinephrine, and serotonin transporters and the 5‐HT2A receptor, most showing distinct class‐dependent profiles, with some indicating a high abuse potential. Background and Purpose New psychoactive substances (NPSs) often emerge on the illicit drug market with ...
Darta Stalberga, Robert Kronstrand, Bianca Schranz, Nick van Zijl, Sebastian Karlman, Soma Aref, Tobias Rautio, Svante Vikingsson, Mattias Persson, Henrik Green   +9 more
wiley   +1 more source

A new chiral heterocyclic 1,1-enediamine as a precursor to piperidines

ARKIVOC, 2003
Raymond C. F. Jones, Simon C. Hirst
doaj   +1 more source

Nickel-Catalyzed Enantioselective Diboration of 1,2-Dihydropyridines: Application and Insight into the Selectivity and Mechanism. [PDF]

ACS Catal
Berwanger MR, Kubenik TK, Liang H, Morken JP.   +3 more
europepmc   +1 more source

Targeted, receptor‐mediated delivery of a masked d‐amino acid cell‐penetrating peptide for cell‐specific phototoxicity

The FEBS Journal, EarlyView.
A targeted phototoxic peptide selectively accumulates in cells expressing chemokine‐like receptor 1 (CMKLR1). Phototoxicity of the native peptide is low, but cleavage by lysosomal protease cathepsin B releases a 6‐tetramethylrhodamine (TMR) labeled nona‐ᴅ‐arginine which mediates lysosomal rupture and cell death upon irradiation.
Moritz List, Eva‐Maria Jülke, Annette G. Beck‐Sickinger   +2 more
wiley   +1 more source

Recurrence of IgA nephropathy in a kidney transplant patient successfully treated with iptacopan-a case report. [PDF]

Front Immunol
Pandav J, Kummangal B, Smith J, De Mattos A, Stack M, Ahmad Z, Andeen N, Kung V, Olyaei A, Rehman S.   +9 more
europepmc   +1 more source

Burden and Risk Factors of CGM‐Detected Hypoglycemia in Older Adults With Type 2 Diabetes

Journal of the American Geriatrics Society, EarlyView.
Among older adults with diabetes using insulin or sulfonylureas, the median time spent in hypoglycemia was 3.4% and ~66% of participants exceeded the target of < 1% time with CGM glucose < 70 mg/dL. ABSTRACT Background Comprehensive data on the burden of biochemical hypoglycemia in older adults with type 2 diabetes are lacking.
Michael Fang, Natalie Rula Daya, Yein Jeon, Justin B. Echouffo‐Tcheugui, B. Gwen Windham, Scott Zeger, Elizabeth Selvin   +6 more
wiley   +1 more source

Regio- and Stereoselective Deprotonation and Functionalization of Strained 1-Aza[n.1.0]bicycles. [PDF]

J Am Chem Soc
Xie T, Plowright T, Somper JD, Fairchild M, Soler J, Tyler JL, Duarte F, Aggarwal VK.   +7 more
europepmc   +1 more source

Development of a Video‐Based Decision Aid for Breast Cancer Screening Among Older Women

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Background Whether to continue breast cancer screening beyond age 74 is uncertain. Decision aids may improve understanding of health information and support informed screening decisions. The goal of this study was to develop a video‐based decision aid for breast cancer screening among older women using patient‐centered design.
Meghan E. Lindsay, Iyanuoluwa Odole, Sadde Mohamed, Claire King, Nancy L. Schoenborn, Mara A. Schonberg, Ilana B. Richman   +6 more
wiley   +1 more source