Results 31 to 40 of about 9,140 (175)

The role of Piper chaba Hunt. and its pure compound, piperine, on TRPV1 activation and adjuvant effect

BMC Complementary Medicine and Therapies, 2020
Background Piper chaba Hunt. is used as an ingredient in Thai traditional preparation for arthritis. Its isolated compound is piperine which shows anti-inflammatory activity. Piperine produces a burning sensation because it activates TRPV1 receptor.
Sumalee Panthong, Yasuyuki Imai, Takeshi Matsuoka, Wakana Suzuki, Tatsuo Watanabe, Yuko Terada, Kohta Kurohane, Kota Sekiguchi, Erina Ogawa, Yukina Endo, Arunporn Itharat   +10 more
doaj   +1 more source

Transcriptome analysis reveals acetylsalicylic acid-mediated accumulation and regulatory network of piperine content in Piper nigrum L.roots

Industrial Crops and Products
Black pepper (Piper nigrum L.) is widely used in food and medicine due to its high piperine content. However, recent studies have revealed that piperine synthesis and accumulation also occur in pepper roots, offering a new pathway for sustainable ...
Mengxuan Li, Jie Kang, Shujun Zhao, Kaige Zhao, Zhigang Li, Can Wang, Yaqi Zhao, Chao Zu, Jianfeng Yang   +8 more
doaj   +1 more source

Diverged Effects of Piperine on Testicular Development: Stimulating Leydig Cell Development but Inhibiting Spermatogenesis in Rats

Frontiers in Pharmacology, 2018
Background: Piperine is the primary pungent alkaloid isolated from the fruit of black peppercorns. Piperine is used frequently in dietary supplements and traditional medicines. The objective of the present study was to investigate the effects of piperine
Xianwu Chen, Fei Ge, Jianpeng Liu, Suhao Bao, Yong Chen, Dongli Li, Yong Li, Tongliang Huang, Xiaofang Chen, Qiqi Zhu, Qingquan Lian, Ren-Shan Ge   +11 more
doaj   +1 more source

Effect of Piperine on Skin Permeation of Curcumin from a Bacterially Derived Cellulose-Composite Double-Layer Membrane for Transdermal Curcumin Delivery

Scientia Pharmaceutica, 2018
Curcumin is a naturally occurring substance with various pharmacological activities. It has not been developed as a drug because of its low bioavailability due to its low solubility and absorption. Piperine is a natural enhancer that is popularly used to
Chutima Jantarat, Pornpak Sirathanarun, Somruedee Boonmee, Wanida Meechoosin, Husna Wangpittaya   +4 more
doaj   +1 more source

Starch Acetate Nanoparticles as Controlled Release Nanocarriers for Piperine [PDF]

, 2021
This paper aims to synthesize starch acetate nanoparticles for controlled release of piperine. Starch acetate is synthesized by chemically modified sago starch with acetylation reaction. Starch acetate nanoparticles with mean particle sizes of 110 nm are
Asniar, Salim, Suh, Cem Pang, Suk, Fun Chin   +2 more
core   +1 more source

Isocratic high-performance liquid chromatography (HPLC) for simultaneous quantification of curcumin and piperine in a microparticle formulation containing Curcuma longa and Piper nigrum

Heliyon, 2021
Poor bioavailability has been reported as a major challenge in the development of curcumin as a pharmaceutical agent. However, co-administration of curcumin with piperine has been shown to improve curcumin bioavailability.
Dewi Setyaningsih, Yosua Agung Santoso, Yustina Sri Hartini, Yosi Bayu Murti, Wouter L.J. Hinrichs, Christine Patramurti   +5 more
doaj   +1 more source

Pharmacokinetics of piperine after oral administration of Sahastara remedy capsules in healthy volunteers

Research in Pharmaceutical Sciences, 2020
Background and purpose: To investigate the pharmacokinetics of piperine after single oral doses of capsules containing Sahastara (SHT) remedy dried ethanolic extracts in healthy Thai volunteers.
Arunporn Itharat, Puritat Kanokkangsadal, Phisit Khemawoot, Preecha Wanichsetakul, Neal M Davies   +4 more
doaj   +1 more source

Combination of curcumin and piperine synergistically improves pain-like behaviors in mouse models of pain with no potential CNS side effects

Chinese Medicine, 2022
Background Curcumin and piperine are major bioactive compounds of Curcuma longa and Piper nigrum, widely consumed as spices and flock medicine. The combinational use of these plants is a common practice in Southeast Asia.
Pawana Boonrueng, Peththa Wadu Dasuni Wasana, Hasriadi, Opa Vajragupta, Pornchai Rojsitthisak, Pasarapa Towiwat   +5 more
doaj   +1 more source

Metabolomic investigation of cisplatin‐induced acute kidney injury in paediatric cancer patients

British Journal of Clinical Pharmacology, EarlyView.
Aim Cisplatin causes acute kidney injury (AKI) in approximately 46% of paediatric cancer patients who receive it. Serum creatinine (SCr) is a poor biomarker of cisplatin nephrotoxicity, because there is a delay between cisplatin infusion and SCr elevation.
Yong Jin Lim, Amy Thachil, Kelly McMahon, Ross T. Tsuyuki, S. Rod Rassekh, Lesley G. Mitchell, Prasad Devarajan, Cherry Mammen, Bruce C. Carleton, Geoffrey D. E. Cuvelier, Victor A. Lewis, Colin J. D. Ross, Alexandra P. Zorzi, Sylvain Baruchel, Raveena Ramphal, Eric Bouffet, Mathieu Lemaire, Tom D. Blydt‐Hansen, Brad L. Urquhart, The Applying Biomarkers to Minimize Long‐Term Effects of Childhood/Adolescent Cancer Treatment (ABLE) Research Study Group, Tom Blydt‐Hansen, Bruce C. Carleton, Geoff D. E. Cuvelier, Sunil Desai, Prasad Devarajan, Conrad Fernandez, Adam Fleming, Paul Gibson, Caroline Laverdiere, Victor Lewis, Mary L. McBride, Bruno Michon, Shahrad Rod Rassekh, Colin J. D. Ross, Christine Sabapathy, Kirk R. Schultz, Michael Zappitelli, Alexandra Zorzi   +37 more
wiley   +1 more source

Piperine suppresses growth and migration of human breast cancer cells through attenuation of Rac1 expression

Asian Pacific Journal of Tropical Biomedicine, 2022
Objective: To investigate the effect of piperine on human breast cancer cells. Methods: The effect of piperine on proliferation and migration of human breast cancer cells, MCF-7 and MDA-MB-231, was investigated using colony formation assays, wound ...
Benjaporn Buranrat, Mutita Junking
doaj   +1 more source