The PII-NAGK-PipX-NtcA Regulatory Axis of Cyanobacteria: A Tale of Changing Partners, Allosteric Effectors and Non-covalent Interactions [PDF]
Frontiers in Molecular Biosciences, 2018 PII, a homotrimeric very ancient and highly widespread (bacteria, archaea, plants) key sensor-transducer protein, conveys signals of abundance or poorness of carbon, energy and usable nitrogen, converting these signals into changes in the activities of ...
Alicia Forcada-Nadal +8 more
doaj +5 more sources
Studies on Cyanobacterial Protein PipY Shed Light on Structure, Potential Functions, and Vitamin B6-Dependent Epilepsy [PDF]
FEBS Letters, 2017 The Synechococcus elongatus COG0325 gene pipY functionally interacts with the nitrogen regulatory gene pipX. As a first step toward a molecular understanding of such interactions, we characterized PipY.
Asuncion Contreras +2 more
exaly +3 more sources
Elevated plasma interleukin-8 as a risk factor for mortality in children presenting with cerebral malaria [PDF]
Infect Dis Poverty, 2023 Background Cerebral malaria (CM) is a neuropathology which remains one of the deadliest forms of malaria among African children. The kinetics of the pathophysiological mechanisms leading to neuroinflammation and the death or survival of patients during ...
Jade Royo +33 more
semanticscholar +2 more sources
A conserved chaperone protein is required for the formation of a noncanonical type VI secretion system spike tip complex [PDF]
J Biol ChemType VI secretion systems (T6SSs) are dynamic protein nanomachines found in Gram-negative bacteria that deliver toxic effector proteins into target cells in a contact-dependent manner.
K. Sachar +7 more
semanticscholar +2 more sources
B vitamin supply in plants and humans: the importance of vitamer homeostasis [PDF]
The Plant Journal, Volume 111, Issue 3, Page 662-682, August 2022., 2022 SUMMARY B vitamins are a group of water‐soluble micronutrients that are required in all life forms. With the lack of biosynthetic pathways, humans depend on dietary uptake of these compounds, either directly or indirectly, from plant sources. B vitamins are frequently given little consideration beyond their role as enzyme accessory factors and are ...
Zeguang Liu +4 more
wiley +2 more sources
PPARγ controls Dectin-1 expression required for host antifungal defense against Candida albicans.
PLoS Pathogens, 2010 We recently showed that IL-13 or peroxisome proliferator activated receptor gamma (PPARgamma) ligands attenuate Candida albicans colonization of the gastrointestinal tract.
Amandine Galès +10 more
doaj +2 more sources
Infected erythrocytes and plasma proteomics reveal a specific protein signature of severe malaria [PDF]
EMBO Mol MedCerebral malaria (CM), the most lethal complication of Plasmodium falciparum severe malaria (SM), remains fatal for 15–25% of affected children despite the availability of treatment. P.
J. Fraering +37 more
semanticscholar +2 more sources
The nitrogen regulator PipX acts in cis to prevent operon polarity. [PDF]
Environmental Microbiology Reports, 2018 Cyanobacteria, phototrophic organisms performing oxygenic photosynthesis, must adapt their metabolic processes to important environmental challenges, like those imposed by the succession of days and nights.
R. Cantos +3 more
semanticscholar +2 more sources
Identification of Plasmodium falciparum and host factors associated with cerebral malaria: description of the protocol for a prospective, case-control study in Benin (NeuroCM) [PDF]
BMJ Open, 2019 Introduction In 2016, an estimated 216 million cases and 445 000 deaths of malaria occurred worldwide, in 91 countries. In Benin, malaria causes 26.8% of consultation and hospitalisation motif in the general population and 20.9% in children under 5 years
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P17, an Original Host Defense Peptide from Ant Venom, Promotes Antifungal Activities of Macrophages through the Induction of C-Type Lectin Receptors Dependent on LTB4-Mediated PPARγ Activation [PDF]
Frontiers in Immunology, 2017 Despite the growing knowledge with regard to the immunomodulatory properties of host defense peptides, their impact on macrophage differentiation and on its associated microbicidal functions is still poorly understood. Here, we demonstrated that the P17,
Khaddouj Benmoussa +23 more
doaj +2 more sources