Results 151 to 160 of about 2,792 (196)
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Pyrimidobenzodiazepines. Synthesis of pirenzepine analog.
Die Pharmazie, 1990The synthesis of Pyrimido[4,5-b][1,5]benzodiazepine derivatives from 4-(o-aminophenylene)amino-5-ethoxy-carbonyl-1,2-dihydro-6-methyl-2 - oxopyrimidine has been described. Pyrimidobenzodiazepine 5 alkylated with N-methyl-N'-chloroacetyl-piperazine gives a product related to pirenzepine. Compound 5 shows weak antianxiety and antidepressive action.
Długosz, Anna, Machoń, Zdzisław
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Central oxotremorine antagonist properties of pirenzepine
Life Sciences, 1988Pirenzepine, the prototype M1 muscarinic receptor antagonist, is an important compound for investigating the functional significance of M1 receptors at the integrated level of behavior but may have limitations imposed by its physical chemistry. Like the nonselective antagonist methylatropine, pirenzepine is highly hydrophilic and crosses the blood ...
J M, Witkin +3 more
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Pirenzepine and Gastrointestinal Motility: Differential Effect of Pirenzepine in the Gut
1985The capacity of pirenzepine to reduce gastric acid secretion in the basal state and after various forms of stimulation is well established by now (Jaup 1981). It is still under discussion whether the ulcer-healing and symptom-relieving effect of pirenzepine is solely due to the moderate acid reduction observed or whether other pharmacological ...
R. W. Stockbrügger +3 more
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PLASMA AND BILIARY DISPOSITION OF PIRENZEPINE IN MAN
Clinical and Experimental Pharmacology and Physiology, 1986SUMMARY1. The binding of pirenzepine, a selective muscarinic receptor antagonist to plasma and bile, was studied in vitro and in vivo. Plasma and hepatic bile were incubated with 14C‐pirenzepine and the bound fraction of 14C‐pirenzepine determined by equilibrium dialysis. The bound fractions were 12.6% (s.e.m.
Lee, SP, Paxton, JW, Choong, YS
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Absolute bioavailability of pirenzepine in intensive care patients
European Journal of Clinical Pharmacology, 1990The absolute bioavailability (f) of pirenzepine was determined in 27 intensive care patients receiving the drug for prophylaxis and therapy of upper gastrointestinal tract bleeding. A multiple oral and intravenous dosage regimen and the times of blood sampling were adapted to individual conditions and treatment.
P, Tanswell +5 more
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Pirenzepine Inhibits Pancreatic Exocrine Secretion in the Rat
Pancreas, 1986Pirenzepine is a newly developed anticholinergic drug that reduces gastric acid secretion and is therefore used in Europe and Japan to treat patients with peptic ulcer. The inhibitory effect of pirenzepine on pancreatic exocrine function and its reversibility were studied in the isolated pancreatic acini and the isolated perfused pancreas of rats.
M, Otsuki +5 more
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Modulation of gallbladder contraction by pirenzepine in man
Pharmacological Research, 1995The mechanism(s) by which cholinergic innervation modulates gallbladder contraction are not fully understood. To elucidate the role of muscarinic M1 receptors in the mediation of gallbladder contraction, we investigated gallbladder volume reduction, plasma cholecystokinin (CCK), and pancreatic polypeptide (PP) responses in humans during cephalic and ...
B, Yeğen +7 more
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Psychometric studies of pirenzepine.
Scandinavian journal of gastroenterology. Supplement, 1981A single dose of 10 mg of pirenzepine given i.m. to 7 healthy volunteers did not elicit local or general signs of intolerance within 6 hours after injection. We also found no significant differences in tests of vegetative symptomatology, visual motor coordination, attention concentration, critical flicker test threshold, nor any other aspects of the ...
E, Kuhn, R, Honzák
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Central action of pirenzepine.
Polish journal of pharmacology and pharmacy, 1982Pirenzepine, (5,11-dihydro-11-[(4-methylpiperazin-1-yl)-acetyl]-6H-pyrido-[2,3] [1,4]-benzodiazepin-6-one dihydrochloride), tested on rats and mice, did not demonstrate any conspicuous behavioral action: it did not counteract reserpine hypothermia in mice, the L-DOPA hypermotility of mice, and (with the exception of very large doses) the amphetamine ...
Z, Rogóz, G, Skuza, H, Sowińska
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[The bronchodilating effect of pirenzepine].
Arerugi = [Allergy], 1992The purpose of this study was to clarify the bronchodilating effect of pirenzepine (PZ) and to verify its mechanism. Ten asthmatic patients (6 men, 4 women: aged 20 to 65, 5 atopic 5 non-atopic) and ten non-asthmatic volunteers (8 men, 2 women: aged 25 to 60) were studied. Forced vital capacity (FVC), forced expiratory volume in one second (FEV1.0) and
T, Shioya +5 more
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