Results 161 to 170 of about 5,284 (226)

PLASMA AND BILIARY DISPOSITION OF PIRENZEPINE IN MAN

Clinical and Experimental Pharmacology and Physiology, 1986
SUMMARY1. The binding of pirenzepine, a selective muscarinic receptor antagonist to plasma and bile, was studied in vitro and in vivo. Plasma and hepatic bile were incubated with 14C‐pirenzepine and the bound fraction of 14C‐pirenzepine determined by equilibrium dialysis. The bound fractions were 12.6% (s.e.m.
Lee, SP, Paxton, JW, Choong, YS
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Central oxotremorine antagonist properties of pirenzepine

Life Sciences, 1988
Pirenzepine, the prototype M1 muscarinic receptor antagonist, is an important compound for investigating the functional significance of M1 receptors at the integrated level of behavior but may have limitations imposed by its physical chemistry. Like the nonselective antagonist methylatropine, pirenzepine is highly hydrophilic and crosses the blood ...
Jeffrey M. Witkin, L.A. Perez, K.M. Witkin, R. Alvarado-Garcia   +3 more
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The Effect of Pirenzepine on Gallbladder Emptying in Humans

The Journal of Clinical Pharmacology, 1986
The effect of the selective antimuscarinic agent, pirenzepine, on gallbladder function was studied in six healthy volunteers, using 99mTc HIDA (N‐[2,6‐diethylthenyl] carbamoylmethyl iminodiacetic acid) hepatobiliary scanning. Pirenzepine, in doses that inhibit gastric acid secretion, did not alter gallbladder emptying responses to sham feeding ...
Vs Chadwick, A.A. Anagnostides, A. Keshavarzian, M.L. Fitzpatrick   +3 more
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Safety and efficacy of 2% pirenzepine ophthalmic gel in children with myopia: a 1-year, multicenter, double-masked, placebo-controlled parallel study.

A M A Archives of Ophthalmology, 2004
OBJECTIVE To evaluate the safety and efficacy of the relatively selective M(1) antagonist pirenzepine hydrochloride in slowing the progression of myopia in school-aged children. METHODS This was a parallel-group, placebo-controlled, double-masked study
R. Siatkowski, S. Cotter, Joseph M. Miller, C. Scher, R. Crockett, G. Novack   +5 more
semanticscholar   +1 more source

Selectivity of pirenzepine in the central nervous system. II. Differential effects of pirenzepine and scopolamine on performance of a representational memory task

Brain Research, 1987
The behavioral effects of the two muscarinic antagonists scopolamine and pirenzepine were examined using a representational memory task for rats in a T-maze. Rats were pretrained to a criterion of 100% correct responses for daily sessions of 10 paired-run trials.
Wayne Hoss, Garth J. Thomas, William S. Messer   +2 more
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Absolute bioavailability of pirenzepine in intensive care patients

European Journal of Clinical Pharmacology, 1990
The absolute bioavailability (f) of pirenzepine was determined in 27 intensive care patients receiving the drug for prophylaxis and therapy of upper gastrointestinal tract bleeding. A multiple oral and intravenous dosage regimen and the times of blood sampling were adapted to individual conditions and treatment.
Bozler G, Schmid E, Allmendinger G, Hofgärtner F, Giesler H, Tanswell P   +5 more
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Fluorescent pirenzepine derivatives as potential bitopic ligands of the human M1 muscarinic receptor.

Journal of Medicinal Chemistry, 2004
Following a recent description of fluorescence resonance energy transfer between enhanced green fluorescent protein (EGFP)-fused human muscarinic M1 receptors and Bodipy-labeled pirenzepine, we synthesized seven fluorescent derivatives of this antagonist
Chouaib Tahtaoui, I. Parrot, P. Klotz, F. Guillier, J. Galzi, M. Hibert, B. Ilien   +6 more
semanticscholar   +1 more source

Pirenzepine Inhibits Pancreatic Exocrine Secretion in the Rat

Pancreas, 1986
Pirenzepine is a newly developed anticholinergic drug that reduces gastric acid secretion and is therefore used in Europe and Japan to treat patients with peptic ulcer. The inhibitory effect of pirenzepine on pancreatic exocrine function and its reversibility were studied in the isolated pancreatic acini and the isolated perfused pancreas of rats.
Toru Oka, Yoshinori Okabayashi, Makoto Otsuki, Shigeaki Baba, Masatoshi Fujii, Takahiko Nakamura   +5 more
openaire   +3 more sources

The role of pirenzepine-sensitive (M1) muscarinic receptors in vagally mediated bronchoconstriction in humans.

American Review of Respiratory Disease, 1989
In a double-blind randomized study, we compared the effects of the M1-selective muscarinic receptor antagonists pirenzepine and the nonselective antagonist ipratropium bromide on bronchoconstriction induced by inhaled sulfur dioxide (SO2) and ...
J.-W. J. Lammers, Philippe Minettte, Monica McCusker, P. J. Barnes   +3 more
semanticscholar   +1 more source

Pirenzepine and Gastrointestinal Motility: Differential Effect of Pirenzepine in the Gut

1985
The capacity of pirenzepine to reduce gastric acid secretion in the basal state and after various forms of stimulation is well established by now (Jaup 1981). It is still under discussion whether the ulcer-healing and symptom-relieving effect of pirenzepine is solely due to the moderate acid reduction observed or whether other pharmacological ...
G. Dotevall, W. Abrahamsson, B. H. Jaup, R. W. Stockbrügger   +3 more
openaire   +2 more sources