Results 171 to 180 of about 5,284 (226)

Lack of pharmacokinetic interaction between cimetidine and pirenzepine

Clinical Pharmacology and Therapeutics, 1985
The oral administration of pirenzepine (PRZ), an antimuscarinic agent, has a variable effect on gastric acid secretion in patients with duodenal ulcer, and it seems to potentiate cimetidine-induced inhibition of secretion. The possibility of a pharmacokinetic interaction between these drugs was examined in eight patients who received cimetidine and PRZ
V Mahachai, Paul A Reilly, A B R Thomson, F Jamali   +3 more
openaire   +3 more sources

Further evidences on gastric cytoprotection exerted by pirenzepine

Pharmacological Research Communications, 1984
Pirenzepine (P) exerts cytoprotective action through a mechanism so far poorly understood. The aim of the present work was to evaluate the protective effect of P and by comparison PGE2, in different cytoprotective models: NaOH 0.2 N; antral ulcer induced by indomethacin; and in an "in vivo" model using ethanol (50% 1ml/rat p.o.) as mucosal barrier ...
M. de Rosa, Diego Foschi, P. Del Soldato, L. Varin   +3 more
openaire   +3 more sources

Double-Blind Trial of Pirenzepine in Acute Pancreatitis

Digestion, 1989
A double-blind clinical trial was carried out to evaluate the efficacy of pirenzepine (PZ) in acute pancreatitis (AP). One hundred and fifteen patients were randomly allocated in three groups, comparable in number, clinical and biochemical parameters. All were hydrated and received nasogastric suction.
S. Rodriguez, Luisa García-Buey, José María Pajares, Ricardo Moreno-Otero, J. Carbo   +4 more
openaire   +3 more sources

A tolerability study of pirenzepine ophthalmic gel in myopic children.

Journal of Ocular Pharmacology and Therapeutics, 2003
PURPOSE The objective of this study was to determine the safety and tolerability of pirenzepine ophthalmic gel (PIR) and the magnitude of mydriatic and accommodative effects in myopic children.
J. Bartlett, K. Niemann, B. Houde, Troy Allred, M. Edmondson, R. Crockett   +5 more
semanticscholar   +1 more source

Pirenzepine in Erosive Duodenitis

Scandinavian Journal of Gastroenterology, 1985
Fifty-five outpatients with chronic duodenal erosions and no previous ulcer history were treated, in a double-blind fashion, with either pirenzepine (50 mg twice daily) or ranitidine (150 mg twice daily) for 6 weeks. The drugs were equally effective in inducing symptomatic relief. At endoscopic control, 70.4% of subjects in the pirenzepine group and 39.
E. Ballarin, Mario Guslandi, S. Daniotti, M. Basilico, Alberto Tittobello   +4 more
openaire   +3 more sources

Characterization of pirenzepine interaction with cytochrome P-450

Xenobiotica, 1985
Pirenzepine interacts with the haem iron of cytochrome P-450 from rat-and pig-liver microsomes, to give absorption spectra with max. at 424-429 nm, and min. at 391-399 nm. Binding to cytochrome P-450 was not detected with human-liver microsomes. Inhibition of 7-ethoxycoumarin dealkylation by pirenzepine using rat-liver microsomes gave values of I50 = 5
S. Rendic, H.-H. Ruf
openaire   +3 more sources

Synthesis and radiosynthesis of N 5 -( 18 F)fluoroethyl-Pirenzepine and its metabolite N 5 -( 18 F)fluoroethyl-LS 75

, 2009
were labelled with 18 F via 2-[ 18 F]fluoroalkylation in position 5 of the benzodiazepinone moiety to obtain N 5 -[ 18 F]fluoroethyl Pirenzepine [ 18 F]-3 and N 5 -[ 18 F]fluoroethyl LS 75 [ 18 F]-4.
P. Riss, V. Soskic, A. Schrattenholz, F. Roesch   +3 more
semanticscholar   +1 more source

Action of Pirenzepine on the Human Urinary Bladder in Vitro

Journal of Urology, 1986
The novel compound pirenzepine was tested for its antimuscarinic effect on the human urinary bladder "in vitro." Its behavior towards the contractions induced by acetylcholine or bethanechol and towards electrically induced contractions was identical to that of atropine. However, its potency was 100 to 300 times lower than that of atropine.
Giulio Bertaccini, Zappia L, Domenico Potenzoni, Antonella Cartellà   +3 more
openaire   +3 more sources

Effects of intracerebroventricular pirenzepine on muscarinic discriminations in rats

European Journal of Pharmacology, 1987
In rats, mixed M1/M2 muscarinic ligands induce a discrimination which is of central origin and selectively mediated by either one or both muscarinic receptor subtypes. In the present study we examined the effects of intracerebroventricular (i.c.v.) pirenzepine, a relatively selective M1 receptor antagonist which does not cross the blood-brain barrier ...
Paul Worms, Jean-Paul Terranova, Alain Perio, Kathleen Biziere, Mireille Jung   +4 more
openaire   +3 more sources

Pirenzepine affects scleral metabolic changes in myopia through a non-toxic mechanism.

Experimental Eye Research, 2002
Whilst the precise mechanism regulating ocular growth is unknown, it has been shown that various pharmacological agents, including the muscarinic receptor antagonists, atropine and pirenzepine, are effective at preventing the development of myopia.
H. Truong, C. Cottriall, A. Gentle, N. Mcbrien   +3 more
semanticscholar   +1 more source