Results 181 to 190 of about 5,284 (226)
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A Selective Radioimmunoassay for the Determination of Pirenzepine in Plasma and Urine
Therapeutic Drug Monitoring, 1987A radioimmunoassay procedure for the determination of pirenzepine in either plasma or urine was demonstrated to be both sensitive and specific as well as highly reproducible. The assay could detect levels as low as 1.25 ng/ml. The sensitivity was sufficient to allow the analysis of biological samples from both pharmacokinetic and clinical studies.
Paul A. Zavorskas +4 more
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ChemInform Abstract: Pyrimidobenzodiazepines. Synthesis of Pirenzepine Analog.
ChemInform, 1991AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Z. Machon, A. Dlugosz
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Bioconjugate chemistry, 2006
Tagged biologically active molecules represent powerful pharmacological tools to study and characterize ligand-receptor interactions. However, the labeling of such molecules is not trivial, especially when poorly soluble tags have to be incorporated. The
D. Bonnet +5 more
semanticscholar +1 more source
Tagged biologically active molecules represent powerful pharmacological tools to study and characterize ligand-receptor interactions. However, the labeling of such molecules is not trivial, especially when poorly soluble tags have to be incorporated. The
D. Bonnet +5 more
semanticscholar +1 more source
No Impairment of Antipyrine Elimination by the Selective Anticholinergic Drug Pirenzepine
Digestion, 1983The elimination kinetics of antipyrine have been established under basal environmental conditions in 6 healthy volunteers. Concentrations of antipyrine in serum were measured by a relatively fast high-pressure liquid chromatography method using a radial-compression chromatographic system.
J.W. Paxton, D.M. Paton, S.E. Foote
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Urologia internationalis, 1995
The densities of M1, M2 and M3 muscarinic receptors in human detrusor muscle were measured using 3H-pirenzepine (3H-PZP), 3H-AFDX-116 (3H-AFDX) and 3H-4-diphenyl-acetoxy-N-methyl-piperidine methidide (3H-4DAMP).
Shun Kondo +2 more
semanticscholar +1 more source
The densities of M1, M2 and M3 muscarinic receptors in human detrusor muscle were measured using 3H-pirenzepine (3H-PZP), 3H-AFDX-116 (3H-AFDX) and 3H-4-diphenyl-acetoxy-N-methyl-piperidine methidide (3H-4DAMP).
Shun Kondo +2 more
semanticscholar +1 more source
Oral pirenzepine does not affect esophageal pressures in man
Digestive Diseases and Sciences, 1986Pirenzepine has been proposed to selectively inhibit gastric acid production. In contrast to classical anticholinergics, pirenzepine does not appear to produce systemic side effects or to strongly inhibit contractions in gastrointestinal tract smooth muscle.
Donald O. Castell +2 more
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Journal of Clinical Endocrinology and Metabolism, 1995
It is known that spontaneous and stimulated GH secretion is reduced in obesity. On the other hand, it has been recently reported that, in obese subjects, plasma GH levels did not change during a hyperglycemic clamp.
M. Maccario +6 more
semanticscholar +1 more source
It is known that spontaneous and stimulated GH secretion is reduced in obesity. On the other hand, it has been recently reported that, in obese subjects, plasma GH levels did not change during a hyperglycemic clamp.
M. Maccario +6 more
semanticscholar +1 more source
What are the indications of pirenzepine?
1989At the parietal gastric cells where hydrochloric acid is secreted there are cholinergic receptors, particularly muscarinic receptors. Pirenzepine is a pyridobenzodiazepine which blocks the Ml muscarinic receptors of the gastric wall exerting a selective anti- muscarinic action.
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Pharmacodynamic evaluation of selective antimuscarinic properties of pirenzepine in the rat
Pharmacological Research Communications, 1982Summary Central and peripheral antimuscarinic properties of pirenzepine following either oral or intravenous administration were evaluated in the rat, in comparison to atropine. Pirenzepine, unlike atropine, was shown to be devoid of central effects and to possess a marked selectivity toward the gastric muscarinic receptors.
Ferdinando Pagani +4 more
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The effect of pirenzepine on spatial learning in the Morris Water Maze
Pharmacology Biochemistry and Behavior, 1988The effects of the selective M1-muscarinic antagonist, pirenzepine, were studied on the Morris Water Maze, a test of spatial learning in the rat. Pirenzepine (0, 10 or 30 micrograms) was administered into lateral ventricle during acquisition of this task.
A.J. Hunter, F.F. Roberts
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