Results 91 to 100 of about 12,593 (182)
Preparation of novel pirfenidone microspheres for lung-targeted delivery: in vitro and in vivo study
, 2016 Dianbo Li, Liping Gong Department of Thoracic Surgery, Linyi Tumor Hospital, Linyi, Shandong, People’s Republic of China Abstract: The aim of this study was to develop and characterize pirfenidone (PF)-loaded chitosan microspheres for lung ...
Gong LP, Li DB
core
Tissue metabolic changes for effects of pirfenidone in rats of acute paraquat poisoning by GC-MS
, 2017 We developed a metabolomic method to evaluate the effect of pirfenidone on rats with acute paraquat (PQ) poisoning, through the analysis of various tissues (lung, liver, kidney, and heart), by gas chromatography–mass spectrometry (GC-MS).
Jianshe Ma +7 more
core +1 more source
Multifunctional Hydrogels: Rational Design and Application in Regenerative Medicine
MedComm, Volume 7, Issue 10, October 2026.Multifunctional hydrogels represent a paradigm shift in regenerative medicine, integrating rational material design with bioactive functionality to address complex tissue repair challenges. This review systematically examines the molecular engineering, structure–function relationships, and translational landscape of advanced hydrogel systems, spanning ...
Linyang Song +4 more
wiley +1 more source
The Egyptian Journal of BronchologyObjectives This systematic review aims to assess the pulmoprotective impacts of pirfenidone against paraquat-induced pulmonary toxicity, focusing on pirfenidone efficacy in mitigating pulmonary fibrosis and improving of pulmonary function.
Sajjad Sadeghi +5 more
doaj +1 more source
Contemporary Concise Review 2025: Interstitial Lung Disease
Respirology, Volume 31, Issue 10, Page 974-982, October 2026.ABSTRACT Multidisciplinary discussion remains the cornerstone of ILD diagnosis and management, with recent advances further strengthening the integration of clinical, radiological, pathological, and molecular information. Updated ILD nomenclature and classification better align disease terminology with underlying morphology and pathobiology.
Tonia Magrì, Luca Richeldi
wiley +1 more source
Pirfenidone-loaded liposomes for lung targeting: preparation and in vitro/in vivo evaluation
, 2015 Hui Meng, Yong XuDepartment of Pharmaceuticals, 85th People’s Liberation Army Hospital, Shanghai, People’s Republic of China Background: The purpose of this study was to develop novel pirfenidone (PFD)-loaded liposomes for targeting to the ...
Meng H, Xu Y
core
No effect of pirfenidone treatment in fulminant bleomycin-induced pneumonitis [PDF]
, 2014 Bleomycin-induced pneumonitis (BIP) is a serious and potentially fatal adverse effect of bleomycin. Currently, BIP is treated on an empirical basis with high dose steroid.
Hyldgaard, Charlotte +9 more
core +1 more source
Respiratory Research, 2019 Introduction Pirfenidone, an antifibrotic drug, slows-down the disease progression in idiopathic pulmonary fibrosis (IPF) over 12 months, however limited data on the decline of lung function and overall survival (OS) in real-world cohorts on longer ...
Monika Zurkova +28 more
doaj +1 more source
Pirfenidone treatment in idiopathic pulmonary fibrosis: A Saudi experience
, 2015 Background: Recent trials involving pirfenidone suggest a beneficial effect in the treatment of idiopathic pulmonary fibrosis (IPF). Objective: To report on the efficacy and safety of pirfenidone in the treatment of patients with IPF, at a tertiary care
Esam H Alhamad
core +1 more source
Metformin enhanced the effect of pirfenidone on pulmonary fibrosis in mice
The Clinical Respiratory JournalBackground The aim of the study is to observe the anti‐inflammatory and antioxidative stress effects of metformin on bleomycin (BLM)‐induced pulmonary fibrosis in mice.
Nana Liu +5 more
doaj +1 more source