Results 101 to 110 of about 12,593 (182)

Effect of Pirfenidone on Vascular Proliferation, Inflammation and Fibrosis in an Abdominal Adhesion Rat Model

Journal of Investigative Surgery, 2017
Aim: To study the efficacy of pirfenidone for prevention of postoperative adhesion formation in an adhesion rat model. Materials and Methods: Eighteen female Wistar rats were subjected to right-sided parietal peritoneum and right uterine horn adhesion ...
Pinar Solmaz Hasdemir, Mahmud Ozkut, Tevfik Guvenal, Melis Aylin Uner, Esat Calik, Semra Oruc Koltan, Faik Mumtaz Koyuncu, Kemal Ozbilgin   +7 more
doaj   +1 more source

Characterization Of Pirfenidone Effects In Human Cardiac Fibroblasts [PDF]

Background Cardiac fibrosis is a major problem in heart diseases, but it is still lacking an effective therapy. The drug pirfenidone has shown several anti-fibrotic effects in animal models of heart diseases and is already approved for the treatment of ...
Meyer, Friederike
core   +1 more source

Is pirfenidone effective for idiopathic pulmonary fibrosis?

, 2017
Idiopathic pulmonary fibrosis has an ominous prognosis and there are virtually no effective therapies. It has been suggested that pirfenidone, an antifibrotic agent, could change its course.
Labarca, Gonzalo, Jeldres, Alejandro
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Comparative Efficacy of Nintedanib and Pirfenidone in Idiopathic Pulmonary Fibrosis: A Systematic Review and Bayesian Network Meta-analysis

Academic Medicine & Surgery
# Objective This study seeks to indirectly compare the efficacy of nintedanib and pirfenidone based on its effects on lung function and patient-centered outcomes. # Methods We performed a systematic review and Bayesian network meta-analysis of phase III
Christopher Fay
doaj   +1 more source

Efficacy and Safety of Pirfenidone in Patients with Progressive Pulmonary Fibrosis: A Retrospective Single-Center Study

Life
Progressive pulmonary fibrosis (PPF) is an emerging subset of fibrotic interstitial lung diseases (ILD), defined by progressive fibrosis despite standard treatment in patients with other than idiopathic pulmonary fibrosis.
Ju Hyun Oh, Jin Han Park, Ji Hoon Jang, Minyoung Her, Een Young Cho, Jae Ha Lee   +5 more
doaj   +1 more source

Pirfenidone attenuates bleomycin-induced changes in pulmonary functions in hamsters

, 1997
The antifibrotic potential of pirfenidone (5-methyl-1-phenyl-2-[1H]- pyridone) was examined in a single intratracheal bleomycin dose hamster model of pulmonary fibrosis.
Mansoor, Jim K., Giri, Shri, Schelegle, Edward S.   +2 more
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Pirfenidone attenuates ischaemia-reperfusion injury in the rat small intestine

, 2002
1. Pirfenidone, an antifibrotic compound with anti-inflammatory effects, has been investigated in a rat model of acute experimental ischaemia-reperfusion injury of the small intestine. 2.
Arumugam, Thiruma V., Margolin, Solomon B., Lindsay Brown, Thiruma V Arumugam, Stephen M Taylor, Shiels, Ian A., Brown, Lindsay, Solomon B Margolin, Ian A Shiels, Taylor, Stephen M.   +9 more
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Upregulation of RGS2: a new mechanism for pirfenidone amelioration of pulmonary fibrosis

, 2016
BACKGROUND: Pirfenidone was recently approved for treatment of idiopathic pulmonary fibrosis. However, the therapeutic dose of pirfenidone is very high, causing side effects that limit its doses and therapeutic effectiveness.
Dennis W. Wolff, Toews, Myron L, Jiang, Haihong, Abel, Peter W, Yaping Tu, Zhang, Qian, Tu, Yaping, Thomas B. Casale, Casale, Thomas B, Myron L. Toews, Panettieri, Reynold A, Haihong Jiang, Stephen Rennard, Yan Xie, Xie, Yan, Rennard, Stephen I, Reynold A. Panettieri, Wolff, Dennis W, Suneet Mehrotra, Qian Zhang, Peter W. Abel, Mehrotra, Suneet   +21 more
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Pirfenidone Alleviates Against Fine Particulate Matter-Induced Pulmonary Fibrosis Modulating via TGF-β1/TAK1/MKK3/p38 MAPK Signaling Pathway in Rats

Biomedicines
Increased exposure to particulate matter (PM) from air pollution causes lung inflammation and increases morbidity and mortality due to respiratory diseases. Pirfenidone is an anti-fibrotic agent used to treat idiopathic pulmonary fibrosis.
Jun-Seok Sung, Il-Gyu Ko, Lakkyong Hwang, Sang-Hoon Kim, Jin Hee Han, Jung Won Jeon, Sae Rom Kim, Jeong Mi Lee, Cheon Woong Choi   +8 more
doaj   +1 more source

Pirfenidone reduces fibronectin synthesis by cultured human retinal pigment epithelial cells

, 1998
Purpose: Pirfenidone is a novel anti-fibrotic drug that has been shown to inhibit fibroblast growth and collagen synthesis induced by transforming growth factor (TGF)-β.
Zhang, S., Shiels, I. A., Taylor, S. M., Ambler, J. S.   +3 more
core   +1 more source