Results 41 to 50 of about 12,593 (182)

A Protective Effect of Pirfenidone in Lung Fibroblast–Endothelial Cell Network via Inhibition of Rho-Kinase Activity

Biomedicines, 2023
Pulmonary fibrosis is a life-threatening disease that has been attributed to several causes. Specifically, vascular injury is thought to be involved in the pathogenesis of fibrosis.
Yusuke Nakamura, Yasuo Shimizu, Mio Fujimaki-Shiraishi, Nobuhiko Uchida, Akihiro Takemasa, Seiji Niho   +5 more
doaj   +1 more source

Combination Therapy With Polydeoxyribonucleotide and Pirfenidone Alleviates Symptoms of Acute Respiratory Distress Syndrome in Human Lung Epithelial A549 Cells [PDF]

International Neurourology Journal, 2020
Purpose Acute respiratory distress syndrome (ARDS) is characterized by its acute onset of symptoms such as bilateral pulmonary infiltrates, severe hypoxemia, and pulmonary edema.
Jae-Joon Hwang, Il-Gyu Ko, Jun-Jang Jin, Lakkyong Hwang, Sang-Hoon Kim, Jung Won Jeon, Seung Sook Paik, Bok Soon Chang, Cheon Woong Choi   +8 more
doaj   +1 more source

Engineered Nanoplatforms Targeting Activated Hepatic Stellate Cells for Liver Fibrosis Therapy via TGF‐β Axis Inhibition and Ferroptosis Induction

Advanced Healthcare Materials, EarlyView.
FeS‐VA@lanifibranor (FVL), an activated hepatic stellate cell (aHSC)‐targeted nanoplatform comprising vitamin A‐functionalized two‐dimensional iron sulfide nanosheets and lanifibranor, is engineered for precision therapy of liver fibrosis. FVL suppresses the TGF‐β signaling pathway by inhibiting SMAD2/3 phosphorylation and induces ferroptosis in aHSCs,
Yinuo Yang, Mengyao Mu, Ke Ren, Hui Liu, Pengju Ma, Yingqi Wang, Mengmeng Zhang, Xueli Xu, Wenzhe Li, Wenshuang Gao, Xiao Sun, Qiang Zhu   +11 more
wiley   +1 more source

Modulation of the TGF‐β/Smad Signaling Pathway by a Bioactive Oxidized Polygonati Rhizoma Polysaccharide Crosslinked Chitosan Hydrogel as Therapeutic Carrier for Parkinson's Disease Treatment

Advanced Science, EarlyView.
An injectable, self‐healing COPRP hydrogel integrates structurally defined oxidized Polygonati rhizoma polysaccharide with carboxymethyl chitosan through dynamic Schiff‐base crosslinking. The bioactive matrix scavenges reactive oxygen species, suppresses neuroinflammation, protects dopaminergic neurons, and supports sustained levodopa release.
Peng Dai, Jikuang Zhao, Chang Xue, Kailei Xu, Liang Yong, Zhuangwei Zhang, Yi Huang, Jianwei Shuai, Xianzhen Chen, Sheng Nie, Junpeng Xu   +10 more
wiley   +1 more source

Pirfenidone suppresses Collagen I expression in corneal fibroblasts: (A) Western blot analysis shows reduction of Collagen I expression by pirfenidone in TGF β induced corneal fibroblasts in a dose dependent manner; Lane1- Untreated, Lane2- TGF β, Lane3- TGF β and 2.5 µg/ml free pirfenidone, Lane 4- TGF β and 5 µg/ml free pirfenidone, Lane5- TGF β and 10 µg/ml free pirfenidone.

, 2013
Data is expressed as Mean ± SEM, N = 3 ...
Ruchit Trivedi (441693), Uday B. Kompella (87959), Sarbani Hazra (441695), Aditya Konar (441694), Rajdeep Guha (441692), Sushovan Chowdhury (441691)   +5 more
core   +1 more source

Factors associated with dose reduction of pirfenidone.

, 2023
Factors associated with dose reduction of pirfenidone.
Chiwook Chung (14564084), Hyo Sin Cho (14564087), Ho Cheol Kim (8566224), Jiwon Kim (573413)   +3 more
core   +1 more source

Real-World Practice Patterns for Prevention and Management of Potential Adverse Events with Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis

Pulmonary Therapy, 2018
Introduction Pirfenidone is an oral antifibrotic agent approved for idiopathic pulmonary fibrosis (IPF). Real-world data on adverse event (AE) management for pirfenidone are limited.
Mark L. Wencel, Tmirah Haselkorn, Susan L. Limb, John L. Stauffer, Elizabeth Morgenthien, Karina Raimundo, Peter P. LaCamera   +6 more
doaj   +1 more source

Establishment and characterization of mouse lymph node fibrosis models

Animal Models and Experimental Medicine, EarlyView.
The design of the entire paper. Schematic illustration of four strategies for establishing mouse lymph node (LN) fibrosis models. The study further compares their fibrotic remodeling patterns and immune alterations. Abstract Background Lymph node (LN) fibrosis occurs in a variety of pathological conditions, including HIV infection, obesity, cancer, and
Yaru Niu, Xu Guan, Jian Ma, Xin Zhang, Yihang Shi, Jinzhu Zhang, Leiqiong Gao, Wei Chen, Xishan Wang   +8 more
wiley   +1 more source

Antifibrotic effect of pirfenidone on human pterygium fibroblasts.

, 2014
OBJECTIVE: The effects of pirfenidone were investigated on cultured human pterygium fibroblasts (HPFs). METHODS: HPFs were obtained from pterygium surgery and subjected to primary culture.
Lee, SY, Lee, K, Yang, H, Park, SY
core   +1 more source

No relevant pharmacokinetic drug-drug interaction between nintedanib and pirfenidone [PDF]

, 2018
Nintedanib and pirfenidone are approved treatments for idiopathic pulmonary fibrosis (IPF). This open-label, two-group trial investigated the pharmacokinetic drug-drug interaction between these two drugs in patients with IPF.Subjects not treated with ...
Fletcher, Sophie, Maher, Toby M, Stowasser, Susanne, Adamali, H, Chaudhuri, Nazia, Wiebe, S, Fletcher, S, Schlenker-Herceg, R, Maher, TM, Wind, S, Baker, A, Wiebe, Sabrina, Hohl, Kathrin, Richeldi, L, Chaudhuri, N, Richeldi L., Hohl, K, Stowasser, S, Adamali, Huzaifa, Schlenker-Herceg, Rozsa, Baker, Andrew, Richeldi, Luca, Wind, Sven   +22 more
core   +2 more sources