Results 131 to 140 of about 112,170 (313)

Attention‐Deficit/Hyperactivity Disorder Through a Circadian Lens: When the Brain's Clock Disrupts Attention Regulation

Medicine Bulletin, EarlyView.
ABSTRACT Attention‐deficit/hyperactivity disorder (ADHD) is increasingly linked to disturbances in circadian regulation, yet this temporal dimension remains insufficiently integrated into research and clinical practice. This perspective synthesises current evidence on circadian misalignment in ADHD, reframing commonly reported sleep disturbances and ...
Ping Wang, Bo Zeng, Bivek Singh
wiley   +1 more source

EXPERIMENTAL DEPRESSION-MODULATED ACTIVATION PATTERN OF THE HYPOTHALAMIC-PITUITARY-ADRENAL AXIS [PDF]

Objective: To study the effect of modelled depression not associated with stress on the hypothalamic-pituitary-adrenal system (HPAS) in mice. Methods: The experiment was conducted on the twenty-four C57BL/6 mice weighing 20-25 g, divided into two groups:
Marina, Kapitonova, Saiful Bahri, Talip, Renad Nikolaevich, Alyautdin, Norhida, Ramli, Nur Amirah Diyana, Razlan, Tin Moe, Nwe   +5 more
core   +1 more source

Living with the Unknown: Intolerance of Uncertainty in Parkinson's Disease

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Parkinson's disease (PD) is marked by pervasive uncertainty due to fluctuating motor and non‐motor symptoms, variable treatment response, and an unpredictable clinical course. Intolerance of uncertainty (IU), a tendency to perceive ambiguity as threatening and respond with worry, avoidance, or decisional paralysis, may be ...
Bradley McDaniels, Gregory M. Pontone, Kuhan Pushparatnam, Indu Subramanian   +3 more
wiley   +1 more source

Perspective: Depression in Persons with Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Depression is a prevalent and disabling syndrome characterized by sustained sadness and/or anhedonia, as well as cognitive and physical symptoms. In Parkinson's disease (PD), depression is both common and clinically challenging due to overlapping symptoms and complex etiologic interactions. Major depressive disorder occurs in approximately 17%
Albert F.G. Leentjens, Gregory M. Pontone   +1 more
wiley   +1 more source

Effects of Perioperative Music Interventions on Emotional Outcomes in Children and Adolescents: A Systematic Review and Meta‐Analysis Integrating Developmental Psychology and Music Education Perspectives

Pediatric Anesthesia, EarlyView.
ABSTRACT Objective To evaluate the effects of perioperative music interventions on emotional outcomes (preoperative anxiety, postoperative fear, emergence delirium) and related physiological parameters in children and adolescents undergoing surgery, and to examine potential effect modifiers.
Yuchen Wen, Jinying Han, Jiayin Gao, Jiaqi Lou, Ziyi Xiang   +4 more
wiley   +1 more source

Severe combined adrenal and gonadal deficiency caused by novel mutations in the cholesterol side chain cleavage enzyme, P450scc

, 2008
Context: Mitochondrial cytochrome P450scc converts cholesterol to pregnenolone in all steroidogenic tissues. Although progesterone production from the fetally-derived placenta is necessary to maintain pregnancy to term, four patients with mutations in ...
Huang, NW, Achermann, JC, Lin, L, Kim, CJ, Miller, WL, Quigley, CA, AvRuskin, TW   +6 more
core  

Investigation of the Mechanism of Cinnamaldehyde in Irritable Bowel Syndrome Based via Network Pharmacology, Molecular Docking, and Animal Experiments

Pediatric Discovery, EarlyView.
Through network pharmacology and molecular docking, it has been discovered that CA can target MAOB, among other proteins, to exert a therapeutic effect in IBS. In vivo, CA lowered visceral hypersensitivity, anxiety and depression‐like behaviors, and fecal water content, highlighting its therapeutic potential for IBS via anti‐inflammatory pathways ...
Qingyang Yu, Boqing Xu, Chunfang Dai, Yayan Pang, Zhifang Dong   +4 more
wiley   +1 more source

Influence of chronic and repeated stress on the pituitary-adrenal system and behavior

, 1975
The role of adrenal glucocorticoids and ACTH in behavior, and the influence of various behavioral situations on the neuroendocrine regulation of the pituitary-adrenal system were investigated.
Levine, S.
core  

Optimizing acupuncture dosing for hormone therapy‐induced hot flashes in cancer patients: A regression‐based analysis and narrative review

Precision Medical Sciences, EarlyView.
Our analysis reveals a clear dose–response relationship between acupuncture sessions and the reduction of hormone therapy‐induced hot flashes. A threshold of approximately 10 sessions establishes a robust quantitative benchmark for achieving clinically meaningful neuro‐autonomic modulation and symptom relief.
Jiaming Cui, Xinyao Wei, Lulu Bin, Shaoxin Sun, Yu Liu, Tao Yang, Zhishun Liu, Jiani Wu   +7 more
wiley   +1 more source