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Molecular Network Basis of Invasive Pituitary Adenoma: A Review
Frontiers in Endocrinology, 2019 Cases with pituitary adenoma comprise 10–25% of intracranial neoplasm, being the third most common intracranial tumor, most of the adenomas are considered to be benign. About 35% of pituitary adenomas are invasive.
Qi Yang, Xuejun Li
semanticscholar +1 more source
BMJ Case Reports, 2014 A healthy 68-year-old man presented in the emergency room with a sudden episode of headache and vomiting together with disequilibrium and crural paresis. The laboratory evaluation revealed hyponatraemia (Na+115 mEq/L). Head MRI demonstrated a giant 40×25×31 mm pituitary lesion (figures 1 and 2). Laboratory studies revealed growth hormone (GH) 0.1 ng/mL
Leão, R, Baptista, J, Vaz Ribeiro, J
openaire +4 more sources
Frontiers in Endocrinology, 2020 Objective: Facial changes are common among nearly all acromegalic patients. As they develop slowly, patients often fail to notice such changes before they become obvious. Consequently, diagnosis and treatment are often delayed.
Tian Meng +21 more
doaj +1 more source
The Genetics of Pituitary Adenomas [PDF]
Journal of Clinical Medicine, 2019 The genetic landscape of pituitary adenomas (PAs) is diverse and many of the identified cases remain of unclear pathogenetic mechanism. Germline genetic defects account for a small percentage of all patients and may present in the context of relevant family history. Defects in AIP (mutated in Familial Isolated Pituitary Adenoma syndrome or FIPA), MEN1 (
Christina Tatsi +1 more
openaire +2 more sources
Frontiers in Endocrinology, 2021 ObjectiveDespite advancements of intraoperative visualization, the difficulty to visually distinguish adenoma from adjacent pituitary gland due to textural similarities may lead to incomplete adenoma resection or impairment of pituitary function. The aim
Alexander Micko +13 more
doaj +1 more source
Growth Hormone (GH)-Releasing Peptide Stimulation of GH Release from Human Somatotroph Adenoma Cells: Interaction with GH-Releasing Hormone, Thyrotropin- Releasing Hormone, and Octreotide. [PDF]
, 1994 The synthetic hexapeptide GH-releasing peptide (GHRP; His-D-Trp-Ala-Trp-D-Phe-Lys-NH2) specifically stimulates GH secretion in humans in vivo and in animals in vitro and in vivo via a still unknown receptor and mechanism.
Brockmeier, S. +7 more
core +1 more source
Goitre and Iodine Deficiency in Europe [PDF]
, 1985 The prevalence of endemic iodine-deficiency goitre in Europe has been reduced in many areas by the introduction of iodination programmes. Recent reports, however, show that goitre remains a significant problem and that its prevalence has not decreased in
Beckers, C. +11 more
core +4 more sources
The role of stereotactic radiosurgery in the multimodal management of growth hormone–secreting pituitary adenomas [PDF]
, 2010 Growth hormone (GH)–secreting pituitary adenomas represent a common source of GH excess in patients with acromegaly. Whereas surgical extirpation of the culprit lesion is considered first-line treatment, as many as 19% of patients develop recurrent ...
Liu, Charles Y. +2 more
core +1 more source
Pituitary adenoma surgery survey: neurosurgical centers and pituitary adenomas
Brain and Spine, 2022 Objective. Pituitary adenoma surgery has evolved rapidly in recent decades. This study aims to determine current practice across a wide range of European neurosurgical centers. Methods. A list of eligible departments performing pituitary adenoma surgery was created. The survey consisted of 58 questions.
David Netuka +9 more
openaire +6 more sources
Frontiers in Endocrinology, 2019 Purpose: Abnormal glucose metabolism is one of the most frequent acromegaly complications. Improvement of glucose metabolism can be observed only in half of acromegaly patients after surgery.
Zihao Wang +17 more
doaj +1 more source