Results 91 to 100 of about 153,261 (262)

A Mouse Model of Depression‐Tumor Multimorbidity Reveals the Mechanism of Tumor Growth Accelerated by Depression

Animal Research and One Health, EarlyView.
Depression accelerates tumor growth by dysregulation of tumor immune microenvironment. (A) Modeling methods: Subcutaneous tumor models were established under chronic unpredictable mild stress conditions, including cold swimming, physical restraint, and food/water deprivation, leading to increased tumor growth.
Yakun Ren, Xinpei Wang, Wen Wang, Xingjiu Yang, Mengyuan Li, Jing Du, Ran Gao   +6 more
wiley   +1 more source

Application of 3D‐Slicer combined with 3D printing technology in training neurosurgery resident physicians' imaging spatial cognition and clinical reasoning: A self‐controlled before‐ and after‐study

Anatomical Sciences Education, EarlyView.
Abstract Neurosurgical residency training requires advanced spatial cognition and 3D anatomical understanding, which traditional methods often fail to adequately develop. This study evaluated a novel educational model integrating 3D Slicer and 3D printing technology to enhance imaging spatial cognition and clinical reasoning among neurosurgery ...
Li Xueyu, Fan Yuanxian, Chen Jiaxing, Li Chuanyu, Chen Yuanbiao, Huang Haineng, Huang Huadong, Luo Kunxiang, Wei Shiyin, Tan Rong   +9 more
wiley   +1 more source

The Relationship Between Pituitary Axis Hormones and All-Cause Mortality in Hospitalized Patients with Chronic Diseases: A Prospective Cohort Study

Medicina
Background and Objectives: The pituitary gland plays a central role in endocrine regulation, and chronic illnesses may disrupt pituitary axis function, potentially influencing clinical outcomes.
Esin Havare, Güneş Topçu, Pınar Yıldız, Emre Hoca, Hayriye Esra Ataoğlu   +4 more
doaj   +1 more source

How developmental stressors affect mitochondrial respiratory function: a systematic review and meta‐analysis

Biological Reviews, EarlyView.
ABSTRACT The environmental conditions organisms experience during early development can have powerful and sustained effects on morphology, physiology, behaviour, and performance. Such developmental effects can influence reproductive success, survival, and life‐history strategies and can be transmitted across generations (i.e.
Ondi L. Crino, Christopher R. Friesen, Geoffrey E. Hill, Dalton C. Leibold, Pablo Recio, Karine Salin, Kristoffer H. Wild, Daniel W.A. Noble   +7 more
wiley   +1 more source

Allostatic load index in patients with pituitary tumours: a case control study

Frontiers in Endocrinology
IntroductionProlonged exposure to pathogenic stress factors leads to multisystemic consumption of the body and adverse changes resulting in the development of allostatic load (AL).
Martyna Strzelec, Dorota Szcześniak, Iga Zendran-Zahorska, Justyna Kuliczkowska-Płaksej, Natalia Słoka, Krzysztof Kujawa, Marek Bolanowski, Aleksandra Jawiarczyk-Przybyłowska   +7 more
doaj   +1 more source

The influence of circadian variables on ecotoxicology metabolomics

Biological Reviews, EarlyView.
ABSTRACT Ecotoxicologists are using metabolomics increasingly to gain insight into toxicological mechanisms and sublethal effects of chemical exposures. Metabolomics offers a sensitive multi‐parameter approach that can detect biochemical responses not obvious using apical and behavioural endpoints.
Ryan I. Lester, David J. Beale, Anthony R. Carroll, Steven D. Melvin   +3 more
wiley   +1 more source

Overlap syndrome between sarcoidosis and Sjögren’s disease presenting as hypopituitarism: case report and review of literature

Endocrine Journal
Sarcoidosis is a granulomatous disease that affects multiple organs; however, pituitary involvement is extremely rare. Although autoimmune diseases, such as Sjögren’s disease (SjD), may coexist, overlapping cases presenting with hypopituitarism are ...
Yuichiro Iwamoto, Noriko Yoshimura, Ayaka Harada, Yoshiro Fushimi, Yui Okamoto, Tomohiko Kimura, Masashi Shimoda, Shuhei Nakanishi, Yo Mizuta, Saeko Tsurui, Seiji Matsumoto, Yoshikazu Koike, Takehiro Nishimura, Hideaki Kaneto   +13 more
doaj   +1 more source

Developmental Morphometry of the Paranasal Sinuses in Subjects Aged 1–25 Years: A Computed Tomography Study

Clinical Anatomy, EarlyView.
ABSTRACT The present study aimed to evaluate the developmental morphometry of the paranasal sinuses using computed tomography (CT) in subjects aged 1–25 years and to characterize age‐related changes in sinus dimensions, volume, and surface area throughout childhood, adolescence, and young adulthood.
Ceyda Şevval Çetin, Aslıhan Artaş, Ali Atadağ, Ömer Faruk Cihan, Orhan Beger   +4 more
wiley   +1 more source

Biography as the Missing Variable in Drug Development: A Case for Bio‐Biographical Mechanistic Profiling

Clinical Pharmacology &Therapeutics, EarlyView.
Most clinical trial failures reflect unmeasured biological heterogeneity. Biography — chronic stress, adversity, trauma, and social isolation—is a neglected source of that heterogeneity, operating through the same molecular pathways drugs engage.
Ralph I. Horwitz
wiley   +1 more source

Clinical characteristics and comparative analysis of PD-1/PD-L1 inhibitor-induced pituitary dysfunction versus other pituitary disorders

Scientific Reports
This study aims to investigate the clinical characteristics of programmed cell death protein-1 (PD-1) or programmed cell death ligand-1 (PD-L1) inhibitors-induced pituitary injury (pituitary-irAE) by comparing with other pituitary diseases.
Yan Xiao, Deyue Jiang, Shengjie Wang, Lei Fu, Lingtong Ye, Erhan Zheng, Zhaohui Lv, Yiming Mu, Wenwen Gong, Qinghua Guo   +9 more
doaj   +1 more source