Results 211 to 220 of about 2,352,806 (292)

Reversible predominant thyrotropin axis dysfunction with meningitis in suspected lymphocytic hypophysitis. [PDF]

JCEM Case Rep
Iinuma K, Amano R, Taki K.
europepmc   +1 more source

Mapping Causal Biology: Mendelian Randomization in the Era of Big Data

Med Research, EarlyView.
Mendelian randomization (MR) leverages genetic variants to mitigate confounding biases in causal inference. This review systematically maps MR's methodological evolution, highlights its expanding applications in epidemiology and drug target validation, and outlines future directions for overcoming current biases through dynamic, multi‐omics, and cross ...
Xuanlu Shen, Chunrun Qu, Zeyu Wang, Jinglin Zhou, Hongwei Liu, Yingjie Li, Bowei Liu, Hao Zhang, Nan Zhang, Jingwei Zhang, Quan Cheng   +10 more
wiley   +1 more source

Acromegaly is associated with an increased incidence of primary malignant tumors: data from a national study in Sweden.

J Clin Endocrinol Metab
Tsatsaris E, Robèrt J, Burman P, Berinder K, Bonelli L, Dahlqvist P, Höybye C, Ragnarsson O, Vouzouneraki K, Åkerman AK, Ekman B, Engström BE.   +11 more
europepmc   +1 more source

Dietary Fatty Acids, Cardiovascular Disease, and Life Expectancy Among Adults With Adverse Mental Health‐Related Characteristics: A Cohort‐Based Target Trial Emulation Study

Med Research, EarlyView.
This study highlights the cardiovascular and longevity benefits of dietary n‐3 PUFAs in individuals with adverse mental health‐related characteristics, particularly ALA and EPA. The target trial emulation framework further provides evidence, revealing EPA and DHA are associated with a lower early‐onset CVD risk in loneliness, while ALA and EPA are ...
Li Chen, Feipeng Cui, Tianqi Tan, Qi Wu, Ying Zhao, Huimin Chen, Zhilei Shan, Yuhan Tang, Xiao Yu, Qianchun Deng   +9 more
wiley   +1 more source

Beyond biochemical control: headache resolution with pasireotide in a patient with acromegaly and residual tumor. [PDF]

JCEM Case Rep
Ekhzaimy AA, Alghamdi A, Alghamlas S.
europepmc   +1 more source

Chronic Pruritic Papular Eruption in an Elderly Man

JEADV Clinical Practice, EarlyView.
Filipe Monteiro, Inês Tribolet‐Abreu, Gustavo Almeida‐Silva, Inês Amaral, Ivânia Soares, Sónia Fernandes, Joana Antunes   +6 more
wiley   +1 more source

Developing the Dopamine D3 Receptor (D3R) Antagonist, (R)‐VK4‐116, as a Non‐Opioid Medication for the Treatment of Opioid Use Disorder

Medicinal Research Reviews, EarlyView.
ABSTRACT Opioid use disorder (OUD) remains a major global health challenge, and currently approved treatments (methadone, buprenorphine, and naltrexone) are all opioid receptor‐targeting drugs with limitations in access, adherence, stigma, and use in polysubstance use disorders. Because the dopamine D3 receptor (D3R) is enriched in limbic brain regions
Chia‐Kuei Wu, Yu‐Chih Lin, Junfeng Huang, Bangwei Ding, Pramod Terse, Rahul Nandre, Haksong Jin, Molly Congdon, Kun Shen, Philip Sanderson, Gregory Tawa, Stephanie Mounaud, Marta De Santis, Donald Lo, Elizabeth A. Ottinger, Amy Hauck Newman   +15 more
wiley   +1 more source

The Mediating Role of Disengaged Coping in the Relationship Between Adverse Childhood Experiences and Substance Use Among Sexual Minority Adults

Research in Nursing &Health, EarlyView.
ABSTRACT Adverse childhood experiences (ACEs) are strongly linked to negative long‐term health outcomes. Sexual minority (SM) individuals face disproportionate exposure to ACEs and their consequences compared to heterosexual peers. However, the mechanisms connecting ACEs to these outcomes remain poorly understood.
Marvin A. Schilt‐Solberg, Julie J. A. M. J. Kurzer   +1 more
wiley   +1 more source

Infantile cholestasis caused by pituitary stalk interruption syndrome: a case report and review of the literature. [PDF]

Transl Pediatr
Liao X, Liu S, Zou B, Shu S, Dong C.
europepmc   +1 more source

Hospitalization Utilization Metric After Major Oncologic Head and Neck Surgery With Microvascular Free Flap

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective The primary length of stay (PLOS) metric fails to capture added time, costs, and reduced patient quality of life (QOL) associated with readmissions. To address these limitations, we propose a novel metric, the hospitalization utilization metric (HUM), which integrates PLOS and readmission LOS (RLOS). Study Design Retrospective review
Nana‐Hawwa Abdul‐Rahman, Anthony Tang, Zainab Balogun, Alexandria Harris, Shaum Sridharan, Matthew E. Spector, Carl H. Snyderman   +6 more
wiley   +1 more source