Results 141 to 150 of about 67,370 (309)

Folding, misfolding, and regulation of intracellular traffic of G protein‐coupled receptors involved in the hypothalamic–pituitary–gonadal axis

open access: yesAndrology, EarlyView.
Abstract Background G protein‐coupled receptors are a large and functionally diverse family of membrane receptors involved in a number of biological processes. Like other proteins, G protein‐coupled receptors need to be properly folded in order to traffic to the plasma membrane and interact with agonist.
Alfredo Ulloa‐Aguirre   +5 more
wiley   +1 more source

Interactions between BNST PACAP stress system and Estrous Cycling in Non-overiectomized Female Rats [PDF]

open access: yes, 2017
The objective of this investigation is to examine possible interactions between the BNST PACAP stress system and hormone levels during the estrous cycle of naturally cycling female rats.
Brumbaugh, Beniah
core   +1 more source

Semen quality in patients with testicular cancer is associated with age and with greatly elevated levels of beta human chorionic gonadotropin

open access: yesAndrology, EarlyView.
Abstract Background Poor semen quality is a well‐known feature in patients with testicular germ cell tumours (GCTs) at the time of diagnosis but the underlying biological reasons are incompletely understood. Objectives This study aimed to identify GCT‐specific clinical factors that are involved with poor semen quality in GCT patients.
Klaus‐Peter Dieckmann   +9 more
wiley   +1 more source

Modified cytoskeletal and extracellular matrix composition in the canine testis after long‐acting gonadotropin‐releasing hormone agonist deslorelin treatment

open access: yesAndrology, EarlyView.
Abstract Background Long‐acting gonadotropin‐releasing hormone (GnRH) agonists are commonly used for fertility control in male dogs. Their effect on testicular histomorphology has not been clarified. Objectives To elucidate the mechanisms underlying androgen withdrawal in response to long‐acting GnRH agonist deslorelin 4.7 mg treatment on testicular ...
Aykut Gram   +5 more
wiley   +1 more source

Maternal, childhood and adolescent influences on Leydig cell functional capacity and circulating INSL3 concentration in young adults: Importance of childhood infections and body mass index

open access: yesAndrology, EarlyView.
Abstract Background The constitutive Leydig cell hormone insulin‐like peptide 3 (INSL3) is considered a good estimate of the adult Leydig cell functional capacity and appears to remain relatively consistent throughout adult male life, only gradually declining into old age.
Richard Ivell   +3 more
wiley   +1 more source

INSL3 Expression in Leydig Cells is a Biomarker for Immunocastration in Boars: Transcriptional Evidence

open access: yesAndrology, EarlyView.
ABSTRACT Background Study aimed to obtain insights into physiological responses to immunocastration in pubertal boars by evaluating effects of alternative vaccination protocols and identifying a reliable immunocastration biomarker. Objectives It was hypothesized that the timing of gonadotropin‐releasing hormone (GnRH) suppression by immunocastration ...
Nina Batorek Lukač   +6 more
wiley   +1 more source

Women's real‐time pain and stress during medical abortion: An ecological momentary assessment study

open access: yesActa Obstetricia et Gynecologica Scandinavica, EarlyView.
Using ecological momentary assessment, this exploratory cohort study tracked women's real‐time pain and stress during first‐trimester medical abortion. Pain and stress peaked on Day 3, with adverse childhood events, stress, bleeding, and more analgesic intake predicting higher pain, underscoring the need for individualized counseling and personalized ...
Anna Felnhofer   +5 more
wiley   +1 more source

Treatment options for immune‐related adverse events associated with immune checkpoint inhibitors

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract The immunotherapy revolution with the use of immune checkpoint inhibitors (ICIs) started with the clinical use of the first ICI, ipilimumab, in 2011. Since then, the field of ICI therapy has rapidly expanded — with the FDA approval of 10 different ICI drugs so far and their incorporation into the therapeutic regimens of a range of malignancies.
Yu Hua Chen   +3 more
wiley   +1 more source

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