Results 151 to 160 of about 99,069 (259)

Targeting ATF6α Attenuates UVB‐Induced Senescence and Improves Skin Homeostasis by Regulating IL8 Expression

Aging Cell, EarlyView.
UVB exposure can trigger senescence in dermal fibroblasts. We show that silencing ATF6α disrupts the establishment of the UVB‐induced senescent phenotype by preventing the onset of several senescent biomarkers and altering the composition of the SASP, consequently affecting its impact on the skin microenvironment.
Joëlle Giroud, Pauline Delvaux, Laura Carlier, Clémentine De Schutter, Nathalie Martin, Raphaël Rouget, Ayeh Bolouki, Valérie De Glas, Inès Bouriez, Florent Bourdoux, Sophie Burteau, Julien Théry, Gauthier Decanter, Nicolas Penel, Yvan de Launoit, Benjamin Ledoux, Corinne Abbadie, Yves Poumay, Olivier Pluquet, Florence Debacq‐Chainiaux   +19 more
wiley   +1 more source

A cytophotometric analysis of anterior pituitary changes in rats exposed to reduced pressure [PDF]

Adaptive cytochemical responses of hormone producing cells of rat anterior pituitary following exposure to simulated high ...
Anthony, A., Rockwell, K.
core   +1 more source

Endocrinology of the hypothalamus and the pituitary gland [PDF]

, 1973
Kuhlendahl, Hans, Scriba, Peter Christian   +1 more
core   +1 more source

Rapid detection of mouse spermatogenic defects by testicular cellular composition analysis via enhanced deep learning model

Andrology, EarlyView.
Abstract Background Histological analysis of the testicular sections is paramount in infertility research but tedious and often requires months of training and practice. Objectives Establish an expeditious histopathological analysis of mutant mice testicular sections stained with commonly available hematoxylin and eosin (H&E) via enhanced deep learning
Nianfei Ao, Min Zang, Yue Lu, Yiping Jiao, Haoda Lu, Chengfei Cai, Xiangxue Wang, Xin Li, Minge Xie, Tingting Zhao, Jun Xu, Eugene Yujun Xu   +11 more
wiley   +1 more source

Testicular histopathology and its association with germ cell numbers, serum concentrations of reproductive hormones, and semen quality

Andrology, EarlyView.
Abstract Background It is well‐established that spermatogenesis, semen quality, and reproductive hormones are interlinked. It is, however, less well‐described how various specific testicular histopathologies are linked to reproductive hormones and semen quality.
Gülizar Saritas, Nina Mørup, Trine H. Johannsen, Anders Juul, Lise Aksglaede, Sofia B. Winge, Kristian Almstrup   +6 more
wiley   +1 more source

Towards an understanding of the pathological basis of senile depression and incident dementia: Implications for treatment

Psychiatry and Clinical Neurosciences, Volume 76, Issue 12, Page 620-632, December 2022., 2022
Senile depression (SD) is a heterogeneous syndrome. Several clinical profiles are more likely to appear in SD than in early‐life depression, but it remains unclear whether the pathophysiology is different. The prevalence of dementia increases with aging, and the underlying pathophysiological processes in the preclinical phase begin even before ...
Ito Kawakami, Jun‐ichi Iga, Sho Takahashi, Yi‐Ting Lin, Hiroshige Fujishiro   +4 more
wiley   +1 more source

Evaluation of dimethandrolone undecanoate in non‐human primates as a candidate for long‐acting injectable male contraceptive

Andrology, EarlyView.
Abstract Background Dimethandrolone undecanoate (DMAU) is under development as a single agent hormonal male contraceptive. DMAU is a prodrug hydrolyzed by esterase(s) to the active metabolite dimethandrolone (DMA) which has dual androgenic and progestogenic actions.
Deborah I. Bunin, Kyuri Kim, Toufan Parman, Janet Gahagen, Mary B. Zelinski, Tiffany Adevai, Christina Wang, Liang Tang, Lalitha Iyer, Aaron Endsley, Diana L. Blithe, Min S. Lee   +11 more
wiley   +1 more source

Periodontitis and metabolic diseases (diabetes and obesity): Tackling multimorbidity

Periodontology 2000, EarlyView., 2023
Abstract Noncommunicable diseases (NCDs) are multifactorial, long‐term, chronic conditions that represent a burden to health‐care systems worldwide as they can only be controlled rather than cured; hence, they require long‐term care. With the exponential increase in NCDs, the occurrence of individuals presenting with more than one chronic disease is ...
Crystal Marruganti, Jean E. Suvan, Francesco D'Aiuto   +2 more
wiley   +1 more source

Kisspeptin as a test of hypothalamic dysfunction in pubertal and reproductive disorders

Andrology, EarlyView.
Abstract The hypothalamic–pituitary–gonadal axis is regulated by the gonadotropin‐releasing hormone pulse generator in the hypothalamus. This is comprised of neurons that secrete kisspeptin in a pulsatile manner to stimulate the release of GnRH, and, in turn, downstream gonadotropins from the pituitary gland, and subsequently sex steroids and ...
Aureliane C. S. Pierret, Aaran H. Patel, Elisabeth Daniels, Alexander N. Comninos, Waljit S. Dhillo, Ali Abbara   +5 more
wiley   +1 more source

Reproductive sterility in aquaculture: A review of induction methods and an emerging approach with application to Pacific Northwest finfish species

Reviews in Aquaculture, Volume 15, Issue 1, Page 220-241, January 2023., 2023
Abstract Aquaculture is the fastest‐growing food‐production sector and is striving to become a long‐term sustainable approach to meet the rising global demand for seafood. During the expansion and advancement of aquaculture, minimizing ecological impacts should occur concomitantly with maximizing production. Farmed fish, often genetically distinct from
Lan Xu, Mingli Zhao, Jun Hyung Ryu, Edward S. Hayman, William T. Fairgrieve, Yonathan Zohar, J. Adam Luckenbach, Ten‐Tsao Wong   +7 more
wiley   +1 more source