Results 81 to 90 of about 99,069 (259)

Corrin Ring Modification in Peptide Drug Development – a Brief History of “Corrination”

ChemMedChem, EarlyView.
This review highlights the applications of vitamin B12 conjugation (“corrination”) to peptides in the field of peptide‐based therapeutics, focusing on improved physio‐chemical properties, targeted/localized drug delivery, and enhanced oral bioavailability.
Nancy Cham, Robert P. Doyle
wiley   +1 more source

A deep learning classification scheme based on augmented-enhanced features to segment organs at risk on the optic region in brain cancer patients [PDF]

arXiv, 2017
Radiation therapy has emerged as one of the preferred techniques to treat brain cancer patients. During treatment, a very high dose of radiation is delivered to a very narrow area. Prescribed radiation therapy for brain cancer requires precisely defining the target treatment area, as well as delineating vital brain structures which must be spared from ...
arxiv  

Intrapituitary Regulatory System of Proliferation of Mammotrophs in the Pituitary Gland [PDF]

, 2004
Anterior pituitary cells produce growth factors plus cytokines and their receptors. Although some of these pituitary growth factors and cytokines are known to be involved in the control of cell differentiation, proliferation and hormone production in the
Takahashi, Sumio
core   +1 more source

Anatomically Consistent Segmentation of Organs at Risk in MRI with Convolutional Neural Networks [PDF]

arXiv, 2019
Planning of radiotherapy involves accurate segmentation of a large number of organs at risk, i.e. organs for which irradiation doses should be minimized to avoid important side effects of the therapy. We propose a deep learning method for segmentation of organs at risk inside the brain region, from Magnetic Resonance (MR) images.
arxiv  

Influence on the adult male Leydig cell biomarker insulin‐like peptide 3 of maternal exposure to estrogenic and anti‐androgenic endocrine disrupting compound mixtures: A retrospective study

Andrologia, Volume 54, Issue 11, December 2022., 2022
Abstract Insulin‐like peptide 3 (INSL3) is a peptide biomarker secreted specifically by the mature Leydig cells of the testes. It is constitutive, has low within‐individual variance, and effectively measures the functional capacity of Leydig cells to make testosterone.
Richard Ivell, Anne Marie Vinggaard, Hiroaki Soyama, Ravinder Anand‐Ivell   +3 more
wiley   +1 more source

Night‐Time Chronotherapy with Methylprednisolone Prevents an Acute Rejection in Pediatric Patients with Liver Transplantation: A Randomized Clinical Trial

Clinical Pharmacology &Therapeutics, EarlyView.
Concept of methylprednisolone chronotherapy to prevent acute rejections. While endogenous cortisol secretion rises in the early morning, the number of lymphocytes in the blood is higher at night, thus exhibiting an antiphase pattern to cortisol secretion. Therefore, compared with the daytime, the infiltration of lymphocytes into immune‐reactive tissues
Kentaro Ushijima, Yukihiro Sanada, Shinya Otomo, Keiko Ogaki, Taiichi Wakiya, Noriki Okada, Yuta Hirata, Yasuharu Onishi, Yasunaru Sakuma, Yukiyo Wada, Akio Fujimura, Koichi Mizuta   +11 more
wiley   +1 more source

Molecular twist transition in chiral and racemic phospholipid monolayers detected by Maxwell-displacement-current measurements [PDF]

, 1999
The molecular basis for the little (lit) mouse phenotype, characterized by a hypoplastic anterior pituitary gland, is the mutation of a single nucleotide that alters Asp 60 to Gly in the growth hormone releasing factor receptor.
Iwamoto, M., Wu, C. X., Xu, X. B., Zhong-can, O. Y., 吴晨旭   +4 more
core   +1 more source

The value of the anterior pituitary gland in gynecology

Kazan medical journal, 1936
Removal of the anterior pituitary gland in infantile animals leads to a cessation of the development of the gonads and growth, as well as to a number of metabolic changes. As shown by relevant studies, the anterior lobe of the pituitary gland produces a hormone that gives a powerful impulse to the sex glands and causes all the phenomena of early ...
openaire   +2 more sources

Methodology of high‐dimensional flow cytometry in monitoring immune microenvironment of pituitary neuroendocrine tumors

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Characterization of the tumor immune microenvironment (TIME) of pituitary neuroendocrine tumors (PitNETs) is crucial for understanding the behavior of different types of PitNETs and identification of possible causes of their aggressiveness, rapid growth, and resistance to therapy.
Marina Yu Loguinova, Valeria V. Mazeeva, Daria V. Lisina, Elena N. Zakharova, Alyona V. Sorokina, Lilya U. Dzhemileva, Andrei Yu Grigoriev, Alexandra S. Shutova, Ekaterina A. Pigarova, Larisa K. Dzeranova, Galina A. Melnichenko, Natalia G. Mokrysheva, Sergei A. Rumiantsev, Vladimir P. Chekhonin   +13 more
wiley   +1 more source

Mathematical Modeling of Perifusion Cell Culture Experiments on GnRH Signaling [PDF]

arXiv, 2015
The effects of pulsatile GnRH stimulation on anterior pituitary cells are studied using perifusion cell cultures, where constantly moving medium over the immo- bilized cells allows intermittent GnRH delivery. The LH content of the outgoing medium serves as a readout of the GnRH signaling pathway activation in the cells.
arxiv