Pubertal Dynamics of Sertoli and Leydig Cell Dysfunction in Klinefelter Syndrome
ABSTRACT Context Klinefelter syndrome (KS), defined by a 47, XXY karyotype, is commonly associated with progressive testicular failure. The precise timing of Sertoli and Leydig cell dysfunction during puberty remains unclear. Objective To determine the onset and progression of testicular insufficiency during puberty in KS, and to assess whether ...
Tredez Axelle +9 more
wiley +1 more source
Sellar Lesions: Novel Aspects in Diagnosis and Management. [PDF]
Kostopoulos G +3 more
europepmc +1 more source
ABSTRACT Introduction The accuracy and safety of cortisol‐stimulating tests (CSTs) for assessing hypothalamic–pituitary–adrenal (HPA) axis integrity, including the diagnosis of central adrenal insufficiency (CAI), in children remain uncertain. Although these tests can simultaneously evaluate cortisol and growth hormone secretion, the present study ...
Mariana Peduti Halah +6 more
wiley +1 more source
NR3C1 is required for normal somatotrope differentiation and Foxo1 expression in pituitary.
Das P +11 more
europepmc +1 more source
Successful Pregnancy in a Woman With Primary Infertility Associated With Isolated Hypogonadotropic Hypogonadism and Partial Empty Sella Syndrome: A Case Report. [PDF]
Houjjaj D, Mouhmouh S, Benbella A.
europepmc +1 more source
ABSTRACT Congenital hypogonadotropic hypogonadism (CHH) is a rare group of disorders of gonadotropin deficiency, either isolated or as a part of multiple pituitary hormone deficiencies (MPHD). We aimed to describe the spectrum of presentation, diagnosis, and management practices of CHH spanning 30 years at an Australian tertiary paediatric centre. This
Minha Kook +3 more
wiley +1 more source
Impaired Pituitary Axis Following Traumatic Skull Base Fracture and Associated Brain Injury. [PDF]
Prasad R, Sharma A, Khare AK.
europepmc +1 more source
Current Approaches to Support Patients to Withdraw From Image and Performance Enhancing Drugs
ABSTRACT Image and performance‐enhancing drugs (IPEDs) include agents such as androgens, growth hormone, and erythropoietin, which are used to enhance appearance and physical performance. Androgens, also known as anabolic‐androgenic steroids (AAS), are the most used IPEDs worldwide.
Elizabeth Hyams +3 more
wiley +1 more source
Oxytocin substitution therapy in patients with AVP deficiency (central diabetes insipidus): study protocol of a double-blind, randomised placebo-controlled trial. [PDF]
Atila C +6 more
europepmc +1 more source

