Results 61 to 70 of about 1,059,440 (253)

Multi‐Layer Transcriptomic Comparison Across Human, Pig, and Mouse Informs Tissue‐ and Trait‐Specific Animal Model Selection

Advanced Science, EarlyView.
We integrated RNA‐seq data from humans, pigs, and mice across 15 matched tissues based on 14 910 one‐to‐one orthologous genes. Cross‐species similarity was systematically evaluated across multiple regulatory layers, including global co‐expression conservation, co‐expression networks, tissue‐specific programs, and 3D genome architecture.
Jingwen Dou, Yong Liao, Xiong Shen, Xin Huang, Zhenshuang Tang, Yuwei Gou, Huajun Zhou, Jingya Xu, Hong Liu, Yue Wang, Keke Liang, Jia Liu, Xiao Zhang, Chenyao Li, Shangjian Wang, Liangliang Fu, Lilin Yin, Xinyun Li, Shuhong Zhao, Xiaolei Liu, Jingjin Li, Yuhua Fu   +21 more
wiley   +1 more source

A delay differential equation mathematical model for the control of the hormonal system of the hypothalamus, the pituitary and the testis in man [PDF]

, 2009
In this paper we develop previously studied mathematical models of the regulation of testosterone by luteinizing hormone and luteinizing hormone release hormone in the human body. We propose a delay differential equation mathematical model which improves
Greenhalgh, David, Khan, Qamar J. A., Sultan Qaboos University, Oman (Funder)   +2 more
core   +3 more sources

A Recessive Mutation Resulting in a Disabling Amino Acid Substitution (T194R) in the LHX3 Homeodomain Causes Combined Pituitary Hormone Deficiency [PDF]

, 2012
Background/Aims: Recessive mutations in the LHX3 homeodomain transcription factor gene are associated with developmental disorders affecting the pituitary and nervous system. We describe pediatric patients with combined pituitary hormone deficiency (CPHD)
Hiedl, Stefan, Duran-Prado, Mario, Lohse, Peter, Roeb, Julia, Rhodes, Simon J., Malik, Raleigh E., Bechtold-Dalla Pozza, Susanne, Park, Soyoung   +7 more
core   +1 more source

WFS1 Deficiency Impairs PIAS4‐Associated SUMOylation and Increases Ubiquitin‐Mediated Spermatogenesis‐Related Protein Degradation Leading to Testicular Male Infertility

Advanced Science, EarlyView.
The findings establish a critical role for WFS1 in human male fertility. Mechanistically, WFS1 interacts with PIAS4 to promote the SUMOylation of key spermatogenesis‐associated proteins, which in turn competitively inhibits their K48‐linked ubiquitin‐mediated degradation during spermatogenesis.
Yunchuan Tian, Guicheng Zhao, Xiang Wang, Xinyao Tang, Gan Shen, Tiechao Ruan, Chuan Jiang, Shikun Zhao, Jincheng Zhang, Xinyue Cui, Liangchai Zhuo, Jun Ma, Yihong Yang, Tingting Lin, Ying Shen   +14 more
wiley   +1 more source

Diagnóstico tardío de síndrome de interrupción del tallo hipofisario

Revista Colombiana de Endocrinología, Diabetes y Metabolismo, 2017
El síndrome de interrupción del tallo hipofisario (PSIS, por sus siglas en inglés) es una anomalía congénita de probable origen genético causante de hipopituitarismo, que se caracteriza por hipoplasia de la adenohipófisis, neurohipófisis ectópica e ...
Vanessa Garzón Graciano, Santiago González Narvaez, Jhon Alexander Alzate Piedrahita, Víctor Hugo Ruiz Granada, Santiago Vallejo González   +4 more
doaj   +1 more source

A Hypothalamic Oxytocinergic–Sympathetic Axis Couples Anxiety Dysregulation With Impaired Tendon–Bone Repair

Advanced Science, EarlyView.
RCI is associated with functional suppression of oxytocinergic neurons in the PVN. Reduced PVNOXT neuronal activity contributes to altered sympathetic regulation involving the IML–sympathetic chain pathway, accompanied by changes in norepinephrine signaling at the BTI.
Liyang Wan, Tingmo Huang, Liyue Zeng, Ruixue Du, Hengshuo Zhang, Shen Liu, Tao Zhang, Jianzhong Hu, Hongbin Lu   +8 more
wiley   +1 more source

Evaluation of anterior pituitary function in patients with chronic brain injury (professional football players)

African Journal of Emergency Medicine, 2013
In present, study we aimed to evaluate the difference of anterior pituitary hormones in professional football players. Method: The study was constructed between 01 January 2012 and 31 October 2012 in Emergency Department of Medicine School, Gaziantep ...
B. Al*, M. Doğan, S. Zengin, S. Taysi, E. Sarcan, C. Yıldırım   +5 more
doaj   +1 more source

Expression of HNr in the anterior pituitary gland.

, 2014
(A) Anterior pituitary sections and (B) cultured anterior pituitary cells from OVX rats were processed for identification of HNr and pituitary hormones by double immunofluorescence.
Daniel Pisera (314728), Marianela Candolfi (44862), Adriana Seilicovich (314730), Sandra Zárate (314720), Mariela Moreno Ayala (652913), María Laura Magri (652912), Gabriela Jaita (314721), Jimena Ferraris (314722), Guadalupe Eijo (314723), María Florencia Gottardo (652911)   +9 more
core   +1 more source

Agents That Affect Pituitary Hormones.pptx

, 2020
This lecture describes the mechanism of action of anterior and posterior pituitary hormones. Besides, it highlights their analogues and inhibitors.
Samah Elaidy (8600724)
core   +1 more source

Hypothalamic POMC Neurons Gate the Fear‐Feeding Trade‐Off

Advanced Science, EarlyView.
Hungry animals must continually arbitrate between feeding and defensive behaviors when confronted with potential threats. We show that hypothalamic POMC neurons engage CRH‐expressing stress circuits and downstream hormonal responses to coordinate this behavioral selection between competing behaviors.
Cristina Miralpeix, Abel Eraso‐Pichot, Vincent Simon, Victor Jouque, Melissa Sadallah, Samantha Clark, Philippe Zizzari, Urszula Skupio, Ana Covelo, Nathalie Dupuy, Jean Charles Nicolas, Astrid Cannich, Thierry Leste‐Lasserre, Guillaume Laplagne, Carmelo Quarta, Giovanni Marsicano, Daniela Cota   +16 more
wiley   +1 more source