Results 71 to 80 of about 101,221 (259)

ZBTB20 is required for anterior pituitary development and lactotrope specification

Nature Communications, 2016
The pituitary is a complex structure with the anterior lobe containing five specialized cell types secreting different hormones. Here Cao et al. unravel a role for ZBTB20 in pituitary development and specifically in lactrotrope specification.
Dongmei Cao, Xianhua Ma, Jiao Cai, Jing Luan, An-Jun Liu, Rui Yang, Yi Cao, Xiaotong Zhu, Hai Zhang, Yu-Xia Chen, Yuguang Shi, Guang-Xia Shi, Dajin Zou, Xuetao Cao, Michael J. Grusby, Zhifang Xie, Weiping J. Zhang   +16 more
doaj   +1 more source

Biography as the Missing Variable in Drug Development: A Case for Bio‐Biographical Mechanistic Profiling

Clinical Pharmacology &Therapeutics, EarlyView.
Most clinical trial failures reflect unmeasured biological heterogeneity. Biography — chronic stress, adversity, trauma, and social isolation—is a neglected source of that heterogeneity, operating through the same molecular pathways drugs engage.
Ralph I. Horwitz
wiley   +1 more source

Goofy/123Cre lineage tracing differentiates olfactory and vomeronasal neurons from GnRH‐1 and terminal nerve neurons during neuronal migration and reveals additional olfactory placode‐derived cells in the brain

Developmental Dynamics, EarlyView.
Abstract The olfactory placode (OP) generates a broad array of chemosensory neurons in the nasal region, including olfactory sensory neurons, vomeronasal sensory neurons, neurons of the septal organ, and Grueneberg ganglion. During invagination, the OP also generates migratory neuronal populations, including gonadotropin‐releasing hormone‐1 (GnRH‐1 ...
Enrico Amato Jr., Mia V. Call, Noah M. LeFever, Mya Aviles‐Carlos, Nikki M. Dolphin, Paolo E. Forni   +5 more
wiley   +1 more source

Panhypopituitarism Presenting with Non Specific Symptoms in a Geriatric Patient: A Case Report [PDF]

Journal of Clinical and Diagnostic Research
Panhypopituitarism is a rare condition in which there is a deficiency of all the hormones released by the pituitary gland. It can occur at any age, from infants and children to adults.
S Hemadharshini, VM Vinodhini, P Renuka, KA Arul Senghor, B Gayathri   +4 more
doaj   +1 more source

Community as Medicine: A Qualitative Exploration of Meaningful Social Support and Health for Trans‐ and Gender‐Diverse People in England

European Journal of Social Psychology, EarlyView.
ABSTRACT The poor mental and physical health of trans‐ and gender‐diverse (TGD) young people is well established and commonly attributed to gender minority stress. Although recent research has shown that social support can mitigate these effects, less attention has been paid to the psychological processes through which this occurs.
Chase Staras, Juliet Wakefield, Daragh McDermott, Bethany Jones   +3 more
wiley   +1 more source

Postoperative Hormonal and Water Balance Disturbances After Non-Functioning Pituitary Macroadenoma Surgery

Clinical and Research Journal in Internal Medicine
Non-functioning pituitary adenomas (NFPAs) are common sellar region tumors. Certain pituitary adenomas are categorized as functional, as they arise from specific cell types that excessively secrete hormones.
Nyoman Yudha, Patan Setiabudi, Gaby Abellia   +2 more
doaj   +1 more source

Seminars in epileptology: Holistic management of epilepsy in adults with intellectual development disorders

Epileptic Disorders, EarlyView.
Abstract This seminar addresses the complexity of the management of epilepsy in adults with intellectual development disorders (IDD), advocating holistic and multidisciplinary care aligned with the learning objectives of the International League Against Epilepsy. Epilepsy is significantly more prevalent in people with IDD, presenting unique diagnostic,
Elena Fonseca, Antonella Riva, Samuel López‐Maza, Malin Zaddach, Marie‐Claire Porter, Ingo Borggraefe, Lance Watkins, Andreas Schulze‐Bonhage, Rohit Shankar, Pasquale Striano, Lina Nashef   +10 more
wiley   +1 more source

HIST1H1E syndrome with deficiency in multiple pituitary hormones. [PDF]

Clin Pediatr Endocrinol, 2023
Tanabe Y, Nomura N, Minami M, Takaya J, Okamoto N, Yanagi K, Kaname T, Fujii Y, Kaneko K.   +8 more
europepmc   +1 more source

WONOEP appraisal: Biomarkers and treatment strategies beyond the synapse

Epilepsia, EarlyView.
Abstract Epilepsy is a heterogeneous neurological disorder affecting more than 70 million people worldwide, posing significant challenges for clinicians due to its complex etiology, diverse manifestations, variable treatment responses, and the inability to predict seizures or disease onset reliably.
Mirte Scheper, Zining Liu, Aristea S. Galanopoulou, Gernot Hlauschek, Benjamin Sinclair, Wai Lam Leung, Stefanie Dedeurwaerdere, Elisabeth Doran, Solomon L. Moshé, David C. Henshall, Ozlem Akman, Pablo M. Casillas‐Espinosa   +11 more
wiley   +1 more source

Intestinal microbiome alterations in pediatric epilepsy: Implications for seizures and therapeutic approaches

Epilepsia Open, EarlyView.
Abstract The intestinal microbiome plays a pivotal role in maintaining host health through its involvement in gastrointestinal, immune, and central nervous system (CNS) functions. Recent evidence underscores the bidirectional communication between the microbiota, the gut, and the brain and the impact of this axis on neurological diseases, including ...
Teresa Ravizza, Greta Volpedo, Antonella Riva, Pasquale Striano, Annamaria Vezzani   +4 more
wiley   +1 more source