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Application of Genetic Engineering Technologies for the Study of Pituitary Development and Neoplasms

open access: bronzeACTA HISTOCHEMICA ET CYTOCHEMICA, 2003
Our studies and review of the literature reported by other investigators indicate the essential use of genetic engineering technology to study the physiologic and pathologic mechanisms of transcription of hormone production and the mechanisms of secretion of appropriate bioactive peptides from the prohormones in the endocrine cells which are equipped ...
Noboru Egashira   +6 more
openaire   +4 more sources

Metastatic pituitary neuroendocrine neoplasms: A case report of a malignant prolactinoma

open access: greenClinical Case Reports
Key Clinical MessageWe report a rare clinical case of a malignant prolactinoma in which the exponential increase of prolactin levels with minimal tumor growth and no response to treatment led to diagnosis of abdominal, thoracic, and vertebral metastases.
Inês Manique   +13 more
openaire   +3 more sources

Clinical characteristics and temporal trends of lumbar drain use in minimally invasive resection of pituitary neoplasms

open access: goldWorld Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
Abstract Objectives Appropriate scenarios of lumbar drain (LD) use in endonasal skull base surgery is an active area of investigation. However, existing data is limited. The purpose of this study is to evaluate the robustness of the NSQIP database to characterize morbidity and complications associated with LD usage concurrent to minimally invasive ...
Benjamin F. Bitner   +6 more
openalex   +2 more sources

Expression of SNAP-25 in human pituitary neoplasms

open access: hybridJournal of Neuropathology and Experimental Neurology, 2007
Michael D. Cusimano   +5 more
openaire   +3 more sources

The role of diabetes in acromegaly associated neoplasia. [PDF]

open access: yesPLoS ONE, 2015
The risk and mortality due to cancer in patients with acromegaly have been previously investigated. Although GH/IGF-1 excess provides a probable pathophysiological explanation, the degree of IGF-1 excess and the role in acromegaly-associated neoplasms of
Sonia Cheng   +4 more
doaj   +1 more source

The hidden hedgehog of the pituitary: hedgehog signaling in development, adulthood and disease of the hypothalamic-pituitary axis

open access: yesFrontiers in Endocrinology, 2023
Hedgehog signaling plays pivotal roles in embryonic development, adult homeostasis and tumorigenesis. However, its engagement in the pituitary gland has been long underestimated although Hedgehog signaling and pituitary embryogenic development are ...
Yehan Bian, Heidi Hahn, Anja Uhmann
doaj   +1 more source

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