No evidence for oncogenic mutations in guanine nucleotide-binding proteins of human adrenocortical neoplasms [PDF]
, 1933 G-Proteins are membrane-bound heterotrimeric polypeptides that couple receptor signals to second messenger systems such as cAMP. Recently, point mutations at 2 codons of the highly preserved alpha-chain of Gs, the adenyl cyclase-stimulating G-protein ...
Travis, W. +3 more
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World Journal of Surgical Oncology, 2009 Background Pituitary carcinomas are rare neuroendocrine tumors affecting the adenohypophysis. The hallmark of these lesions is the demonstration of distant metastatic spread. To date, few well-documented cases have been reported in the literature.
Sippel Rebecca +2 more
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Genetic regulation of pituitary gland development in human and mouse [PDF]
, 2009 Normal hypothalamopituitary development is closely related to that of the forebrain and is dependent upon a complex genetic cascade of transcription factors and signaling molecules that may be either intrinsic or extrinsic to the developing Rathke’s ...
Robin Lovell-Badge +9 more
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Pituitary metastases as a rare variant of intracranial metastasis
Бюллетень сибирской медицины, 2008 Metastatiс spread of neoplasms to the pituitary gland is a relatively common finding in autopsy series of cancer patients. The majority of these patients were asymptomatic.
A. V. Osnitskaya, V. Ye. Olyushin
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A retrospective analysis of postoperative hypokalemia in pituitary adenomas after transsphenoidal surgery [PDF]
PeerJ, 2017 Background Pituitary adenoma is one of the most common intracranial neoplasms, and its primary treatment is endoscopic endonasal transsphenoidal tumorectomy.
Lili You +5 more
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A CASE OF INFANTILISM ASSOCIATED WITH PITUITARY NEOPLASM [PDF]
Archives of Internal Medicine, 1913 Illness depending on pituitary disturbances is becoming more frequently recognized. The case of infantilism here reported is presented as an example of an interesting condition worthy of addition to the records of pituitary disorders. CASE REPORT History .—H.
openaire +2 more sources
The FGFR4-G388R polymorphism promotes mitochondrial STAT3 serine phosphorylation to facilitate pituitary growth hormone cell tumorigenesis. [PDF]
PLoS Genetics, 2011 Pituitary tumors are common intracranial neoplasms, yet few germline abnormalities have been implicated in their pathogenesis. Here we show that a single nucleotide germline polymorphism (SNP) substituting an arginine (R) for glycine (G) in the FGFR4 ...
Toru Tateno +5 more
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Pituitary tumors and the risk of other malignancies: is the relationship coincidental or causal?
Endocrine Oncology, 2023 Pituitary adenomas are benign neoplasms of the pituitary. The most prevalent are prolactinomas and non-functioning pituitary adenomas, followed by growth hormone-and ACTH-secreting adenomas.
Sandra Pekic +2 more
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Resistant prolactinoma: Is it monoclonal or polyclonal?
Indian Journal of Endocrinology and Metabolism, 2013 Prolactinomas are solitary benign neoplasms and resistance to dopamine agonists occur in a small percentage of prolactinomas. Multiple pituitary adenomas are reported in less than 1% of pituitary adenomas and rarely result in resistant prolactinoma.
K. V. S. Hari Kumar, Pitambar Prusty
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Expressions of Cushing’s syndrome in multiple endocrine neoplasia type 1
Frontiers in Endocrinology, 2023 Cushing’s syndrome (CS) resulting from endogenous hypercortisolism can be sporadic or can occur in the context of familial disease because of pituitary or extra-pituitary neuroendocrine tumors.
William F. Simonds
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