Results 21 to 30 of about 105,804 (267)

Successful Treatment of Intracranial Glioblastoma Xenografts With a Monoamine Oxidase B-Activated Pro-Drug

EBioMedicine, 2015
The last major advance in the treatment of glioblastoma multiforme (GBM) was the introduction of temozolomide in 1999. Treatment with temozolomide following surgical debulking extends survival rate compared to radiotherapy and debulking alone.
Martyn A. Sharpe, Andrew D. Livingston, Taylor L. Gist, Pardip Ghosh, Junyan Han, David S. Baskin   +5 more
doaj   +1 more source

Up-regulation of sex-determining region Y-box 9 (SOX9) in growth hormone-secreting pituitary adenomas

BMC Endocrine Disorders, 2021
Background Pituitary adenomas are benign brain tumors that cause considerable morbidity and neurological symptoms. SOX9 as a regulatory transcriptional mediator affects normal and tumor cell growth with an undefined role in pituitary adenomas ...
Farzad Izak Shirian, Mohammad Ghorbani, Mohammad E. Khamseh, Mehrnaz Imani, Mahshid Panahi, Alimohammad Alimohammadi, Mitra Nourbakhsh, Vahid Salimi, Masoumeh Tavakoli-Yaraki   +8 more
doaj   +1 more source

Treatment adherence and persistence with long-acting somatostatin analog therapy for the treatment of acromegaly: a retrospective analysis

BMC Pharmacology and Toxicology, 2017
Background Many patients with acromegaly require medical treatment that includes somatostatin analogs (SSAs). Long-acting SSA formulations are widely used, due in part to increased patient convenience and increased treatment adherence vs daily ...
Michelle H. Gurel, Yi Han, Andrea L. Stevens, Aaron Furtado, David Cox   +4 more
doaj   +1 more source

Impact of Pituitary Stalk Preservation on Tumor Recurrence/Progression and Surgically Induced Endocrinopathy After Endoscopic Endonasal Resection of Suprasellar Craniopharyngiomas

Frontiers in Neurology, 2021
Objective: To investigate the factors associated with recurrence/progression after endoscopic endonasal resection of suprasellar craniopharyngiomas.
Zhengyuan Chen, Zhengyuan Chen, Zhengyuan Chen, Zhengyuan Chen, Zhengyuan Chen, Zhengyuan Chen, Zengyi Ma, Zengyi Ma, Zengyi Ma, Zengyi Ma, Zengyi Ma, Zengyi Ma, Wenqiang He, Wenqiang He, Wenqiang He, Wenqiang He, Wenqiang He, Wenqiang He, Xuefei Shou, Xuefei Shou, Xuefei Shou, Xuefei Shou, Xuefei Shou, Xuefei Shou, Zhao Ye, Zhao Ye, Zhao Ye, Zhao Ye, Zhao Ye, Zhao Ye, Yichao Zhang, Yichao Zhang, Yichao Zhang, Yichao Zhang, Yichao Zhang, Yichao Zhang, Qilin Zhang, Qilin Zhang, Qilin Zhang, Qilin Zhang, Qilin Zhang, Qilin Zhang, Nidan Qiao, Nidan Qiao, Nidan Qiao, Nidan Qiao, Nidan Qiao, Nidan Qiao, Xiang Zhou, Xiang Zhou, Xiang Zhou, Xiang Zhou, Xiang Zhou, Xiang Zhou, Xiaoyun Cao, Xiaoyun Cao, Xiaoyun Cao, Xiaoyun Cao, Xiaoyun Cao, Xiaoyun Cao, Min He, Min He, Zhaoyun Zhang, Zhaoyun Zhang, Hongying Ye, Hongying Ye, Yiming Li, Yiming Li, Shiqi Li, Shiqi Li, Shiqi Li, Shiqi Li, Shiqi Li, Shiqi Li, Yao Zhao, Yao Zhao, Yao Zhao, Yao Zhao, Yao Zhao, Yao Zhao, Ming Shen, Ming Shen, Ming Shen, Ming Shen, Ming Shen, Ming Shen, Yongfei Wang, Yongfei Wang, Yongfei Wang, Yongfei Wang, Yongfei Wang, Yongfei Wang, Yongfei Wang   +92 more
doaj   +1 more source

Inhibition of mTORC1 by lncRNA H19 via disrupting 4E-BP1/Raptor interaction in pituitary tumours

Nature Communications, 2018
LncRNA H19 has been shown to be aberrantly expressed in different cancers. Here, the authors show that H19 lncRNA is downregulated in pituitary adenomas and H19 is able to impede pituitary tumorigenesis via disruption of 4E-BPB1 and Raptor interaction to
Ze Rui Wu, Lichong Yan, Yan Ting Liu, Lei Cao, Yu Hang Guo, Yong Zhang, Hong Yao, Lin Cai, Han Bing Shang, Wei Wei Rui, Gang Yang, Xiao Biao Zhang, Hao Tang, Yu Wang, Jin Yan Huang, Yong Xu Wei, Wei Guo Zhao, Bing Su, Zhe Bao Wu   +18 more
doaj   +1 more source

Assessment of Evidence Regarding Minimally Invasive Surgery vs. Conservative Treatment on Intracerebral Hemorrhage: A Trial Sequential Analysis of Randomized Controlled Trials

Frontiers in Neurology, 2020
Introduction: The recent publication of a trial failed to prove the efficacy of minimally invasive surgery (MIS) in patients with intracerebral hemorrhage.
Xiang Zhou, Li Xie, Yuksel Altinel, Nidan Qiao, Nidan Qiao, Nidan Qiao   +5 more
doaj   +1 more source

Vascular flow empty shadow in pituitary neuroendocrine tumors: A case report and review of literature

Clinical Case Reports, 2023
Key Clinical Message To investigate the blood supply characteristics and surgical significance of pituitary neuroendocrine tumors with vascular flow void signal in tumors.
Jiansheng Zhong, Jun Li, Shousen Wang
doaj   +1 more source

Impact of Radiation Therapy on Physical and Psychosocial Health of Adolescents and Young Adults: A Joint Report From the Children's Oncology Group AYA and Radiation Oncology Committees

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Rates of cancer among adolescents and young adults (AYA), age 15–39 years, are increasing. Consequently, radiation oncologists are treating more AYAs who have diagnoses spanning both pediatric and adult practices. Compared to pediatric and older adult patients, AYAs face a unique set of challenges.
Hesham Elhalawani, Rachel K. Peterson, Avani D. Rao, Laurie J. McKenzie, Ahmed Magdy Elmotayam, Leslie Chang, Michael Roth, Susan L. McGovern   +7 more
wiley   +1 more source

Assessing the association of tumor consistency and gland manipulation on hormonal outcomes and delayed hyponatremia in pituitary macroadenoma surgery

Interdisciplinary Neurosurgery, 2020
Background: Neuro-endocrine dysfunction such as electrolyte imbalance and hypopituitarism are among the most frequent surgical complications following pituitary macroadenoma resection.
Solon Schur, Oliver Lasry, Marc.A. Tewfik, Salvatore Di Maio   +3 more
doaj   +1 more source

Transcranial Sonography in the Diagnosis of Pituitary Tumor—A Direct Comparison With MRI

Frontiers in Endocrinology, 2021
BackgroundTranscranial sonography (TCS) is a convenient tool for detecting certain brain diseases, such as brain tumors. Few studies have reported on the use of TCS in the area of Sella turcica.
Lei He, Jinghan Zhang, Tengfei Yu, Yue Du, Xinyao Liu, Wen He, Wen He   +6 more
doaj   +1 more source