Results 1 to 10 of about 3,206,101 (306)
How to Classify and Define Pituitary Tumors: Recent Advances and Current Controversies
Frontiers in Endocrinology, 2021 Pituitary tumors are very complex and heterogeneous and have a very wide range of proliferative and aggressive behaviors, and how to define and classify these tumors remains controversial.
Congxin Dai +8 more
doaj +2 more sources
Genetically engineered mouse models of pituitary tumors [PDF]
Frontiers in Oncology, 2014 Animal models constitute valuable tools for investigating the pathogenesis of cancer as well as for preclinical testing of novel therapeutics approaches.
David A Cano +4 more
doaj +2 more sources
Endocrinology and Metabolism Clinics of North America, 2015 Pituitary tumors are commonly encountered intracranial neoplasms that are invariably benign. Classic oncogene mutations are not encountered in these tumors, and disrupted cell cycle control and growth factor signaling likely contribute to pathogenesis and natural history.
Шломо Мелмед
openalex +3 more sources
Increased expression of programmed death ligand 1 (PD-L1) in human pituitary tumors [PDF]
OncoTarget, 2016 PURPOSE: Subsets of pituitary tumors exhibit an aggressive clinical courses and recur despite surgery, radiation, and chemotherapy. Because modulation of the immune response through inhibition of T-cell checkpoints has led to durable clinical responses ...
Agar, Nathalie Y. R. +13 more
core +4 more sources
Orthotopic pituitary tumors generated by stereotaxic GC cell injection in immunocompetent rats [PDF]
Acta Neuropathologica CommunicationsInnovative treatment strategies for pituitary tumors are necessary to limit the disease burden and to improve survival in cases of carcinomas. The paucity and inaccuracy of available preclinical models substantially hamper pituitary research and drug ...
Etienne Lefevre +10 more
doaj +2 more sources
Aggressive Pituitary Tumors [PDF]
Neuroendocrinology, 2015 Pituitary adenomas are common intracranial tumors that are mainly considered as benign. Rarely, these tumors can exhibit an aggressive behavior, characterized by gross invasion of the surrounding tissues, resistance to conventional treatment leading to early and frequent recurrences.
Chatzellis, E. +3 more
openaire +4 more sources
Temozolomide and Pituitary Tumors: Current Understanding, Unresolved Issues, and Future Directions
Frontiers in Endocrinology, 2018 Temozolomide, an alkylating agent, initially used in the treatment of gliomas was expanded to include pituitary tumors in 2006. After 12 years of use, temozolomide has shown a notable advancement in pituitary tumor treatment with a remarkable improvement
Luis V. Syro +5 more
doaj +2 more sources
PIT-1/SF-1-positive pituitary tumors in patients with acromegaly: transcriptomic perspective [PDF]
Acta Neuropathologica CommunicationsNeuroendocrine pituitary tumors (PitNETs) are classified based on clinical manifestation and expression of pituitary cell lineage-specific transcription factors (TFs) and hormones.
Julia Rymuza, Qilin Zhang, Mateusz Bujko
doaj +2 more sources
Frontiers in Endocrinology, 2015 Pituitary tumors, that origin from excessive proliferation of a specific subtype of pituitary cell, are mostly benign tumors, but may cause significant morbidity in affected patients, including visual and neurologic manifestations from mass-effect, or ...
Erika ePeverelli +5 more
doaj +2 more sources
Pseudocapsule and pseudocapsule-based extracapsular resection in pituitary neuroendocrine tumors
Frontiers in Endocrinology, 2022 Since Costello et al. proposed the concept of pseudocapsule of pituitary neuroendocrine tumors (PitNETs) in 1936, many studies have been published on its occurrence, development process, histopathology, and morphology.
Xiao Bin Wang +6 more
doaj +1 more source