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How to Classify and Define Pituitary Tumors: Recent Advances and Current Controversies
Frontiers in Endocrinology, 2021 Pituitary tumors are very complex and heterogeneous and have a very wide range of proliferative and aggressive behaviors, and how to define and classify these tumors remains controversial.
Congxin Dai +8 more
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Increased expression of programmed death ligand 1 (PD-L1) in human pituitary tumors [PDF]
OncoTarget, 2016 PURPOSE: Subsets of pituitary tumors exhibit an aggressive clinical courses and recur despite surgery, radiation, and chemotherapy. Because modulation of the immune response through inhibition of T-cell checkpoints has led to durable clinical responses ...
Agar, Nathalie Y. R. +13 more
core +4 more sources
Genetically engineered mouse models of pituitary tumors [PDF]
Frontiers in Oncology, 2014 Animal models constitute valuable tools for investigating the pathogenesis of cancer as well as for preclinical testing of novel therapeutics approaches.
David A Cano +4 more
doaj +2 more sources
Orthotopic pituitary tumors generated by stereotaxic GC cell injection in immunocompetent rats. [PDF]
Acta Neuropathol CommunInnovative treatment strategies for pituitary tumors are necessary to limit the disease burden and to improve survival in cases of carcinomas. The paucity and inaccuracy of available preclinical models substantially hamper pituitary research and drug ...
Lefevre E +10 more
europepmc +2 more sources
Temozolomide and Pituitary Tumors: Current Understanding, Unresolved Issues, and Future Directions
Frontiers in Endocrinology, 2018 Temozolomide, an alkylating agent, initially used in the treatment of gliomas was expanded to include pituitary tumors in 2006. After 12 years of use, temozolomide has shown a notable advancement in pituitary tumor treatment with a remarkable improvement
Luis V. Syro +5 more
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PIT-1/SF-1-positive pituitary tumors in patients with acromegaly: transcriptomic perspective [PDF]
Acta Neuropathol CommunNeuroendocrine pituitary tumors (PitNETs) are classified based on clinical manifestation and expression of pituitary cell lineage-specific transcription factors (TFs) and hormones.
Rymuza J, Zhang Q, Bujko M.
europepmc +2 more sources
Frontiers in Endocrinology, 2015 Pituitary tumors, that origin from excessive proliferation of a specific subtype of pituitary cell, are mostly benign tumors, but may cause significant morbidity in affected patients, including visual and neurologic manifestations from mass-effect, or ...
Erika ePeverelli +5 more
doaj +2 more sources
Pseudocapsule and pseudocapsule-based extracapsular resection in pituitary neuroendocrine tumors
Frontiers in Endocrinology, 2022 Since Costello et al. proposed the concept of pseudocapsule of pituitary neuroendocrine tumors (PitNETs) in 1936, many studies have been published on its occurrence, development process, histopathology, and morphology.
Xiao Bin Wang +6 more
doaj +1 more source
Sprouting Angiogenesis in Human Pituitary Adenomas
Frontiers in Oncology, 2022 IntroductionAngiogenesis in pituitary tumors is not fully understood, and a better understanding could help inform new pharmacologic therapies, particularly for aggressive pituitary tumors.Materials and Methods219 human pituitary tumors and 12 normal ...
Jie Zhou +15 more
doaj +1 more source
Pituitary, 2023 The Pituitary Society established the concept and mostly qualitative parameters for defining uniform criteria for Pituitary Tumor Centers of Excellence (PTCOEs) based on expert consensus.
A. Giustina +18 more
semanticscholar +1 more source