Tumor microenvironment defines the invasive phenotype of AIP-mutation-positive pituitary tumors
Oncogene, 2019 The molecular mechanisms leading to aryl hydrocarbon receptor interacting protein (AIP) mutation-induced aggressive, young-onset growth hormone-secreting pituitary tumors are not fully understood.
Sayka Barry +15 more
semanticscholar +1 more source
How to Classify Pituitary Neuroendocrine Tumors (PitNET)s in 2020
Cancers, 2020 Adenohypophyseal tumors, which were recently renamed pituitary neuroendocrine tumors (PitNET), are mostly benign, but may present various behaviors: invasive, “aggressive” and malignant with metastases.
J. Trouillas +5 more
semanticscholar +1 more source
Pituitary tumors in patients with MEN1 syndrome
Clinics, 2012 We briefly review the characteristics of pituitary tumors associated with multiple endocrine neoplasia type 1. Multiple endocrine neoplasia type 1 is an autosomal-dominant disorder most commonly characterized by tumors of the pituitary, parathyroid ...
Luis V. Syro +8 more
doaj +1 more source
A rare cause of recurrent spontaneous pneumothorax: Birt-hogg-dube syndrome [PDF]
, 2018 Birt-Hogg-Dube (BHD) syndrome is an unusual disorder characterized by the triad of cutaneous lesions, renal tumors and lung cysts. In cases with BHD syndrome, the frequency of recurrent pneumothorax is increased due to presence of multiple lung cysts. It
Demirci, M. +3 more
core +1 more source
The Microenvironment of Pituitary Tumors—Biological and Therapeutic Implications
Cancers, 2019 The tumor microenvironment (TME) includes resident and infiltrative non-tumor cells, as well as blood and lymph vessels, extracellular matrix molecules, and numerous soluble factors, such as cytokines and chemokines. While the TME is now considered to be
M. Ilie +3 more
semanticscholar +1 more source
Corticotropinoma as a Component of Carney Complex. [PDF]
, 2017 Known germline gene abnormalities cause one-fifth of the pituitary adenomas in children and adolescents, but, in contrast with other pituitary tumor types, the genetic causes of corticotropinomas are largely unknown.
Chittiboina, Prashant +11 more
core +2 more sources
Gel chromatographic characterization of immunoreactive adrenocorticotropin in patients with ACTH hypersecretion [PDF]
, 1989 We investigated the molecular size of circulating immunoreactive ACTH by gel chromatography in patients with ACTH hypersecretion due to various disorders of the hypothalamic-pituitary-adrenal axis.
A Chatelain +19 more
core +1 more source
Management of pituitary spindle cell oncocytomas: A case report and review of the literature
Interdisciplinary Neurosurgery, 2021 Pituitary spindle cell oncocytomas represent a rare pathologic entity within the differential diagnosis for pituitary tumors. As part of a class of tumors that includes low grade non-endocrine pituitary tumors such as pituicytomas and granular cell ...
Hael Abdulrazeq +6 more
doaj +1 more source
Anti-VEGF Therapy in Refractory Pituitary Adenomas and Pituitary Carcinomas: A Review
Frontiers in Oncology, 2021 Most pituitary tumors are considered benign adenomas, and only 0.1%–0.2% of them present metastasis and are defined as pituitary carcinomas (PCs). Refractory pituitary adenomas (PAs) lie between benign adenomas and true malignant PCs and are defined as ...
Congxin Dai +4 more
doaj +1 more source
Growth Hormone (GH)-Releasing Peptide Stimulation of GH Release from Human Somatotroph Adenoma Cells: Interaction with GH-Releasing Hormone, Thyrotropin- Releasing Hormone, and Octreotide. [PDF]
, 1994 The synthetic hexapeptide GH-releasing peptide (GHRP; His-D-Trp-Ala-Trp-D-Phe-Lys-NH2) specifically stimulates GH secretion in humans in vivo and in animals in vitro and in vivo via a still unknown receptor and mechanism.
Brockmeier, S. +7 more
core +1 more source