Results 51 to 60 of about 101,852 (311)

Pituitary Tumor Transforming Gene Overexpression Facilitates Pituitary Tumor Development [PDF]

Endocrinology, 2006
Intrinsic and extrinsic stimuli result in profound pituitary growth changes ranging from hypoplasia to hyperplasia. Pituitary tumor transforming gene (PTTG) abundance correlates with pituitary trophic status. Mice with Pttg inactivation exhibit pituitary hypoplasia, whereas targeted pituitary PTTG overexpression driven by α-subunit glycoprotein (αGSU ...
Ines, Donangelo, Shiri, Gutman, Eva, Horvath, Kalman, Kovacs, Kolja, Wawrowsky, Michael, Mount, Shlomo, Melmed   +6 more
openaire   +2 more sources

Experimental Evidence and Clinical Implications of Pituitary Adenoma Stem Cells

Frontiers in Endocrinology, 2020
Pituitary adenomas, accounting for 15% of diagnosed intracranial neoplasms, are usually benign and pharmacologically and surgically treatable; however, the critical location, mass effects and hormone hypersecretion sustain their significant morbidity ...
Roberto Würth, Stefano Thellung, Alessandro Corsaro, Federica Barbieri, Tullio Florio, Tullio Florio   +5 more
doaj   +1 more source

A Biomarker‐Driven Ovary–Endometrium Organ‐on‐a‐Chip Mimicking 3D Multicellular Complexity and Menstrual Cyclicity for Predicting Reproductive Toxicity

Advanced Science, EarlyView.
We present a dual‐organ, biomarker‐integrated ovaryendometrium organ‐on‐a‐chip that recapitulates 3D tissue complexity, menstrual cycle dynamics, and hormonal crosstalk. This platform enables real‐time, cell‐typespecific fluorescent readouts of reproductive toxicity using ANGPTL4 and SERPINB2 as early‐response reporters.
Soo‐Rim Kim, Eun‐kyung Min, Choon‐Mi Lee, Chan Hum Park, Byung‐Chul Oh, YunJae Jung, In‐Sun Hong   +6 more
wiley   +1 more source

Acromegaly: pathogenesis & treatment [PDF]

, 2019
Acromegaly is a multi-system disorder whose etiology is most often traced back to a growth hormone-secreting pituitary adenoma (PA). Growth hormone (GH) secretion promotes insulin-like growth factor 1 (IGF-1) release from peripheral tissues, leading to ...
Tilvawala, Megha
core  

Paving the Way to Elucidate Hg's Role in Tumorigenesis

Advanced Science, EarlyView.
Tumorigenesis can result from diverse environmental carcinogens. Among them, mercury—a lifelong bioaccumulative Group 2B carcinogen—has tumorigenic potential that remains poorly understood due to confounding co‐exposures and limited organ‐specific data.
Shouying Li, Rong Zhong, Zhenyang Yu, Hualing Fu, Jin Chen, Jia Wei, Ningwei Zhao, Le Qu, Tiantian Li, Wenli Tang, Huan Zhong   +10 more
wiley   +1 more source

Whole-Exome Sequencing Study of Thyrotropin-Secreting Pituitary Adenomas [PDF]

, 2018
学位記番号 ...
Santosh, Sapkota, Santosh, Sapkota, サントス, サプコタ   +2 more
core  

Primordial germ cell-like cells residing in the pituitary may serve as the origin of intracranial germ cell tumors

Scientific Reports
Intracranial germ cell tumors (iGCTs) are rare, histologically classified as extragonadal germ cell tumors, and predominantly affect children and adolescents.
Yi Zhang, Lei Zhang, Zhengyang Shen, Jifang Liu, Zhang Ye, Kan Deng, Yong Yao, Daishu Han   +7 more
doaj   +1 more source

Pediatric pituitary neuroendocrine tumors–a 13-year experience in a tertiary center

Frontiers in Oncology, 2023
IntroductionPediatric pituitary neuroendocrine tumor is a rare condition, and despite previous research focusing on this specific group, the main factors influencing the surgical cure rate have not been identified.MethodsWe conducted a single-center ...
Xiaoxu Li, Kan Deng, Yi Zhang, Ming Feng, Bing Xing, Wei Lian, Yong Yao   +6 more
doaj   +1 more source

4‐Hydroxybenzyl Alcohol Mitigates Hyperlipidemia‐Associated Depression by Inhibiting Neuroinflammation via the NKIRAS2/NF‐κB Pathway

Advanced Science, EarlyView.
4‐HBA upregulates NKIRAS2 levels, inhibiting the activation of the NF‐κB pathway and subsequently reducing the levels of neuroinflammatory markers. This modulation helps restore normal mood and behavior in hyperlipidemic conditions, providing a potential therapeutic strategy for managing hyperlipidemia‐associated depression.
Ying Zhang, Meng Teng, Wenxuan He, Lanzhou Li, Yongfeng Zhang, Shimiao Wang, Chunyue Wang, Di Wang   +7 more
wiley   +1 more source

Effect of delayed acquisition times on Gadolinium-enhanced MRI of the presumably normal canine brain [PDF]

, 2011
A delay in imaging following intravenous contrast medium administration has been recommended to reduce misdiagnoses. However, the normal variation of contrast enhancement in dogs following a delay has not been characterized.
Brannan, N., Cameron, G., Hammond, G., Joslyn, S., Novellas Torroja, R., Sullivan, M.   +5 more
core   +1 more source