Results 71 to 80 of about 62,608 (262)

Biography as the Missing Variable in Drug Development: A Case for Bio‐Biographical Mechanistic Profiling

Clinical Pharmacology &Therapeutics, EarlyView.
Most clinical trial failures reflect unmeasured biological heterogeneity. Biography — chronic stress, adversity, trauma, and social isolation—is a neglected source of that heterogeneity, operating through the same molecular pathways drugs engage.
Ralph I. Horwitz
wiley   +1 more source

Suspected silent pituitary somatotroph neuroendocrine tumor associated with acromegaly-like bone disorders: a case report

BMC Endocrine Disorders
Background Growth hormone (GH) positive pituitary neuroendocrine tumors do not always cause acromegaly. Approximately one-third of GH-positive pituitary tumors are classified as non-functioning pituitary tumors in clinical practice.
Tongxin Xiao, Xinxin Mao, Ou Wang, Yong Yao, Kan Deng, Huijuan Zhu, Lian Duan   +6 more
doaj   +1 more source

Pituitary Metastasis of Clear Cell Renal Carcinoma Mimicking Pituitary Macroadenoma – Case Report

Brazilian Neurosurgery
Introduction Pituitary tumors account for 25% of all primary brain tumors and for 15% of overall intracranial expansive masses. Pituitary metastases, in contrast, are a rare condition, estimated as 1.8% of all resected sellar lesions.
Lucas Caixeta Nogueira, Luciano Ricardo França da Silva, Luiz Eduardo Mendonça Tenório, Cleiton Onofre de Menezes, João Victor Franco de Oliveira Calado, Luiz Felipe Gomes Rosa, Guilherme Figner Moussalem, Nicolai Máximo Leventi   +7 more
doaj   +1 more source

Epileptogenic lesions in the Australian epilepsy project: A harmonized 3‐T magnetic resonance imaging protocol and its diagnostic yield

Epilepsia, EarlyView.
Abstract Objective Detection of epilepsy‐causing structural brain lesions on magnetic resonance imaging (MRI) is critical for diagnosis, prognosis, and treatment planning in people with epilepsy. We aimed to establish an epilepsy‐directed multisite harmonized 3‐T MRI acquisition protocol for the Australian Epilepsy Project (AEP) and describe the ...
David N. Vaughan, David F. Abbott, Amanda Anderson, Greg Fitt, Suyi Ooi, Heath Pardoe, Donna Parker, Yuliya Perchyonok, Eric Pierre, Chris Kokkinos, Robert E. Smith, Michael Stewart, Bahman Tahayori, Chris Tailby, Graeme D. Jackson, the Australian Epilepsy Project Investigators, Zanfina Ademi, Patrick Kwan, Karen Oliver, Mangor Pedersen   +19 more
wiley   +1 more source

Gut‐microbiota‐brain Axis and post‐traumatic epilepsy

Epilepsia Open, EarlyView.
Abstract There has been growing evidence that perturbations in gut‐microbiota‐brain axis (GMBA) are involved in mechanisms of chronic sequelae of traumatic brain injury (TBI). This review discusses the connection between GMBA and post‐traumatic epilepsy (PTE), the latter being a common outcome of TBI.
Andrey Mazarati
wiley   +1 more source

Temozolomide and Pituitary Tumors: Current Understanding, Unresolved Issues, and Future Directions

Frontiers in Endocrinology, 2018
Temozolomide, an alkylating agent, initially used in the treatment of gliomas was expanded to include pituitary tumors in 2006. After 12 years of use, temozolomide has shown a notable advancement in pituitary tumor treatment with a remarkable improvement
Luis V. Syro, Fabio Rotondo, Mauricio Camargo, Leon D. Ortiz, Carlos A. Serna, Kalman Kovacs   +5 more
doaj   +1 more source

Intestinal microbiome alterations in pediatric epilepsy: Implications for seizures and therapeutic approaches

Epilepsia Open, EarlyView.
Abstract The intestinal microbiome plays a pivotal role in maintaining host health through its involvement in gastrointestinal, immune, and central nervous system (CNS) functions. Recent evidence underscores the bidirectional communication between the microbiota, the gut, and the brain and the impact of this axis on neurological diseases, including ...
Teresa Ravizza, Greta Volpedo, Antonella Riva, Pasquale Striano, Annamaria Vezzani   +4 more
wiley   +1 more source

Novel planning pipeline utilizing the Surgical Theater system for pediatric epilepsy surgery

Epilepsia Open, EarlyView.
Abstract Objective Advances in the analysis and collation of radiographic datasets have enhanced presurgical planning for various neurosurgical procedures, including clipping of cerebral aneurysms, surgical resection of tumors, and arteriovenous malformation management.
Lisa B. E. Shields, Hunain Abri, Cemal Karakas, Shannon D. Davis, Ian S. Mutchnick   +4 more
wiley   +1 more source

An efficient deep learning model for brain tumour detection with privacy preservation

CAAI Transactions on Intelligence Technology, EarlyView., 2023
Abstract Internet of medical things (IoMT) is becoming more prevalent in healthcare applications as a result of current AI advancements, helping to improve our quality of life and ensure a sustainable health system. IoMT systems with cutting‐edge scientific capabilities are capable of detecting, transmitting, learning and reasoning.
Mujeeb Ur Rehman, Arslan Shafique, Imdad Ullah Khan, Yazeed Yasin Ghadi, Jawad Ahmad, Mohammed S. Alshehri, Mimonah Al Qathrady, Majed Alhaisoni, Muhammad H. Zayyan   +8 more
wiley   +1 more source

The gut microbiome and drug‐resistant epilepsy: Microbiome–antiseizure medication interactions and implications for pharmacoresistance

Epilepsia Open, EarlyView.
Abstract Drug‐resistant epilepsy (DRE) affects approximately one‐third of patients with epilepsy and represents a major unmet clinical need. While traditional hypotheses of pharmacoresistance have focused on alterations in drug targets, efflux transporter overexpression, and intrinsic disease severity, the gut microbiome has recently emerged as a ...
Khaled Zammar, Majd A. AbuAlrob, Musab Ali, Simona Lattanzi, Boulenouar Mesraoua   +4 more
wiley   +1 more source