Results 61 to 70 of about 3,101,103 (310)

Counterbalancing O‐GlcNAcylation and STAT3 Phosphorylation in Ventral Tegmental Area Dopaminergic Neurons Mediates Behavioral Adaptations to Acute Restraint Stress

Advanced Science, EarlyView.
Acute restraint stress enhances STAT3Ser727 phosphorylation in dopaminergic neurons in mice. This modification promotes the upregulation of GABBR2 and GABRB3, reduces neuronal activity, and contributes to anxiety‐like behavior and diminished reward‐seeking following stress exposure.
Mingshuo Shao, Yi Wu, Haiyang Wang, Chenchun Zhang, Ying Zhu, Yan Jiang, Changyou Jiang, Qiumin Le, Xing Liu, Lan Ma, Feifei Wang   +10 more
wiley   +1 more source

HIGD1A Alleviates Oxidative Stress Related Ovarian Hypofunction by Enhancing Granulosa Cell Functions via NF‐κB/SOD2 Signaling Pathway

Advanced Science, EarlyView.
HIGD1A maintains redox homeostasis in granulosa cells by modulating SOD2‐mediated dismutation of superoxide into H2O2, which is cleared by CAT and GPX enzymes. However, reduced HIGD1A activates the NF‐κB pathway and upregulates SOD2, leading to intracellular H2O2 accumulation due to impaired clearance.
Huiying Li, Siying Cai, Hongbei Mu, Tianli Chang, Xiaofei Wang, Tianyu Tang, Tengyun Dong, Yu Zhang, Ling Zhang, Huaibiao Li, Liquan Zhou, Wenpei Xiang   +11 more
wiley   +1 more source

GHSR‐Foxo1 Signaling in Macrophages Promotes Liver Fibrosis via Inflammatory Response and Hepatic Stellate Cell Activation

Advanced Science, EarlyView.
Macrophage GHSR‐Foxo1 axis regulates CCl4‐induced liver fibrosis by promoting inflammation and TGF‐β1‐mediated HSC activation. GHSR activates PKA‐dependent phosphorylation of Foxo1 at serine 273, promoting macrophage pro‐inflammatory polarization to enhance the production of pro‐inflammatory cytokines that damage hepatocytes, thereby inducing liver ...
Da Mi Kim, Quan Pan, Zeyu Liu, Weiqi Ai, Hye Won Han, Sakhila K. Banu, Robert Y.L. Tsai, Gus A. Wright, Shaodong Guo, Yuxiang Sun   +9 more
wiley   +1 more source

The effect of endoscopic transsphenoidal somatotroph tumors resection on pituitary hormones: systematic review and meta-analysis

World Journal of Surgical Oncology, 2023
Purpose Currently, endoscopic transsphenoidal surgery is the main treatment for pituitary neuroendocrine tumors (PitNETs). Excision of the tumor may have positive or negative effects on pituitary endocrine function, and the pituitary function of ...
Ding Nie, Qiuyue Fang, Wakam Wong, Songbai Gui, Peng Zhao, Chuzhong Li, Yazhuo Zhang   +6 more
doaj   +1 more source

Alternative Models for Anticancer Drug Discovery From Natural Products Using Binary Tumor‐Microenvironment‐on‐a‐Chip

Advanced Science, EarlyView.
This study presents a binary tumor‐microenvironment‐on‐a‐chip (T‐MOC) system incorporating multicellular tumor spheroids (MCTs) as an alternative preclinical platform to evaluate the efficacy of anticancer natural products. The T‐MOC model reproduces in vivo drug delivery barriers and physiological conditions, enabling morphological analysis to predict
Youngwon Kim, Si Hyeon Chae, Dahae Lee, Bum Soo Lee, Jiseok Lim, Hyo‐Il Jung, Ki Hyun Kim, Bongseop Kwak   +7 more
wiley   +1 more source

Metabolic profiling reveals distinct metabolic alterations in different subtypes of pituitary adenomas and confers therapeutic targets

Journal of Translational Medicine, 2019
Background Pituitary adenomas are common brain tumors. Although transsphenoidal surgery are able to achieve extensive tumor removal, the rate of recurrence ranges from 5 to 20% depending on the different subtype.
Jie Feng, Hua Gao, Qi Zhang, Yang Zhou, Chuzhong Li, Sida Zhao, Lichuan Hong, Jinjin Yang, Shuyu Hao, Wan Hong, Zhengping Zhuang, Guowang Xu, Yazhuo Zhang   +12 more
doaj   +1 more source

Target delineation and optimal radiosurgical dose for pituitary tumors

Radiation Oncology, 2016
Stereotactic radiosurgery (SRS) delivered as either single-fraction or multi-fraction SRS (2–5 fractions) is frequently employed in patients with residual or recurrent pituitary adenoma. The most common delivery systems used for SRS include the cobalt-60
G. Minniti, M. Osti, M. Niyazi
semanticscholar   +1 more source

Impact of Ghrelin‐Depleting Gastrectomy on Long‐Term Endocrine and Metabolic Health With a Focus on Skeletal Muscle and Bone Mineral Content

Annals of Gastroenterological Surgery, EarlyView.
This study investigates the long‐term endocrine and metabolic consequences of ghrelin‐depleted gastrectomy, with a focus on skeletal muscle mass and bone mineral content. Sustained reductions in serum desacyl‐ghrelin were linked to lower IGF‐1 levels, resulting in significant loss of muscle and bone.
Hiroki Harada, Takuya Goto, Keishi Yamashita, Hiroyuki Minoura, Kota Okuno, Shohei Fujita, Mikiko Sakuraya, Tadashi Higuchi, Koshi Kumagai, Naoki Hiki   +9 more
wiley   +1 more source

Refractory pituitary adenoma: a novel classification for pituitary tumors

OncoTarget, 2016
Pituitary adenomas are classified as typical or atypical, invasive or noninvasive, and aggressive or nonaggressive based on pathological features, radiological findings, and clinical behavior.
Congxin Dai, M. Feng, Xiao-hai Liu, Si-hai Ma, bowen sun, X. Bao, Yong Yao, K. Deng, Yu Wang, B. Xing, W. Lian, Dingrong Zhong, Wenbin Ma, Renzhi Wang   +13 more
semanticscholar   +1 more source

A Hybrid Transfer Learning Framework for Brain Tumor Diagnosis

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
A novel hybrid transfer learning approach for brain tumor classification achieves 99.47% accuracy using magnetic resonance imaging (MRI) images. By combining image preprocessing, ensemble deep learning, and explainable artificial intelligence (XAI) techniques like gradient‐weighted class activation mapping and SHapley Additive exPlanations (SHAP), the ...
Sadia Islam Tonni, Md. Alif Sheakh, Mst. Sazia Tahosin, Md. Zahid Hasan, Taslima Ferdaus Shuva, Touhid Bhuiyan, Muhammad Ali Abdullah Almoyad, Nabil Anan Orka, Md. Tanvir Rahman, Risala Tasin Khan, M. Shamim Kaiser, Mohammad Ali Moni   +11 more
wiley   +1 more source