Results 61 to 70 of about 110,519 (362)

A Biomarker‐Driven Ovary–Endometrium Organ‐on‐a‐Chip Mimicking 3D Multicellular Complexity and Menstrual Cyclicity for Predicting Reproductive Toxicity

Advanced Science, EarlyView.
We present a dual‐organ, biomarker‐integrated ovaryendometrium organ‐on‐a‐chip that recapitulates 3D tissue complexity, menstrual cycle dynamics, and hormonal crosstalk. This platform enables real‐time, cell‐typespecific fluorescent readouts of reproductive toxicity using ANGPTL4 and SERPINB2 as early‐response reporters.
Soo‐Rim Kim, Eun‐kyung Min, Choon‐Mi Lee, Chan Hum Park, Byung‐Chul Oh, YunJae Jung, In‐Sun Hong   +6 more
wiley   +1 more source

Acromegaly: pathogenesis & treatment [PDF]

, 2019
Acromegaly is a multi-system disorder whose etiology is most often traced back to a growth hormone-secreting pituitary adenoma (PA). Growth hormone (GH) secretion promotes insulin-like growth factor 1 (IGF-1) release from peripheral tissues, leading to ...
Tilvawala, Megha
core  

Structure of the TPR Domain of AIP: Lack of Client Protein Interaction with the C-Terminal alpha-7 Helix of the TPR Domain of AIP Is Sufficient for Pituitary Adenoma Predisposition [PDF]

, 2012
PMCID: PMC3534021This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
A Laenger, A Puga, A Raitila, AF Daly, AF Daly, AJ Perry, AP Heaney, B Bukau, B Panaretou, BD Hollingshead, C Prodromou, C Prodromou, C Scheufler, CA Leontiou, Chrisostomos Prodromou, CM Greiser, D Spengler, DR Bell, E Heliovaara, EB Krissinel, F Glaser, G Huang, G Siligardi, G Trivellin, GB Bolger, Giampaolo Trivellin, Giorgio Colombo, H Ashkenazy, HS Chahal, HS Chahal, HS Chahal, HS Feigelson, I Persson, IW Davis, JL Marlowe, LA Carver, LA Carver, Laura C. Hernández-Ramírez, LH Pearl, Lihong Zhou, M Fujimoto, M Landau, M Linnert, M Yano, M Zhang, MP Mayer, Márta Korbonits, N Kuzhandaivelu, O Vierimaa, P Emsley, P Pocar, PH Pang, PV Afonine, Q Zeng, Rhodri M. L. Morgan, S Igreja, S Safe, S. Mark Roe, SK de Oliveira, SK de Oliveira, SK Kolluri, W Cai, Z Ozfirat   +62 more
core   +3 more sources

Development of Endogenous Protein Probes for Characterizing Surface Proteins and Cellular Interactors of Extracellular Vesicles

Advanced Science, EarlyView.
The proximity labeling enzyme APEX2 is displayed on extracellular vesicle (EV) surfaces via genetic fusion with EV‐sorting scaffolds, enabling in situ biotinylation of native surface proteins, adsorbed corona components, and interacting cellular proteins.
Wenyi Zheng, Metoboroghene Mowoe, Wenqing Hou, Daniel W. Hagey, Koshi Imami, Samir EL Andaloussi   +5 more
wiley   +1 more source

Spatially Resolved Multiomics Reveals Metabolic Remodeling and Autophagy Activation in Adamantinomatous Craniopharyngiomas

Advanced Science, EarlyView.
Multiomics integration analysis reveals the “cystic fluid–tumor cell” metabolic coupling that mediates active choline/ethanolamine uptake of tumor cells from cystic fluid and PC/PE synthesis pathways reprogramming that mediating autophagy pathway activation within ACP. ABSTRACT Adamantinomatous craniopharyngioma (ACP), a benign yet highly recurrent and
Dongting Chen, Yahui Gao, Yulin Wang, Ting Lei, Zheng Qu, Yuhan An, Jiaxu Fu, Xin Li, Fangjun Liu, Yan Li   +9 more
wiley   +1 more source

Causal relationship between gut microbiota and pituitary neuroendocrine tumors: a bidirectional Mendelian randomization

Discover Oncology
Background Previous observational studies have hinted at a connection between the gut microbiota and pituitary neuroendocrine tumors, yet the causal nature of this relationship remains uncertain.
Wencai Wang, Menghao Liu, Zun Wang, Wei Ye, Xianfeng Li   +4 more
doaj   +1 more source

Residual Tumor Confers a 10-Fold Increased Risk of Regrowth in Clinically Nonfunctioning Pituitary Tumors. [PDF]

, 2019
ObjectiveWe evaluated tumor recurrence and regrowth rates following endoscopic transnasal transsphenoidal (TNTS) surgical removal in a consecutive series of clinically nonfunctioning pituitary adenomas (CNFTs).DesignRetrospective chart review of clinical,
Bergsneider, Marvin, Dabbagh, Asmaa, Heaney, Anthony P, Linetsky, Michael, Maletkovic, Jelena, Salamon, Noriko, Vinters, Harry V, Wang, Marilene B, Yong, William H, Zahid, Abdul, Zhang, Dongyun   +10 more
core   +1 more source

A middle cerebral artery ischemic stroke occurring in a child with a large prolactinoma. [PDF]

, 2020
Pituitary adenomas are rare in children, and often present with symptoms of headache, nausea or emesis, visual disturbance, or hormonal hypersecretion.
Amara, Dominic, Clerkin, Patricia, Gupta, Nalin, Oh, Taemin   +3 more
core  

Parathyroid localization [PDF]

, 1986
Twenty-nine consecutive patients with suspected primary hyperparathyroidism were examined preoperatively using ultrasound, sonographically guided fine needle aspiration, and aspirate immunostaining for PTH.
Borisch, B., Gutekunst, R., Hafermann, W., Kiffner, E., Löhrs, U., Scriba, Peter Christian, Thies, E., Valesky, A.   +7 more
core   +1 more source

Educational Impact of Artificial Intelligence‐Navigation Surgery on Anatomical Landmark Recognition in Medical Students

Annals of Gastroenterological Surgery, EarlyView.
This study evaluated the educational impact of artificial intelligence (AI)‐navigation surgery that provides real‐time anatomical landmark recognition during laparoscopic cholecystectomy for medical students. Thirty students were randomized into surgeon‐guided, self‐learning, and AI‐learning groups, and their performance was assessed using Dice ...
Shigeo Ninomiya, Yusuke Matsunobu, Tabito Oyama, Hiroomi Takayama, Takashi Masuda, Teijiro Hirashita, Yuichi Endo, Tatsushi Tokuyasu, Masafumi Inomata   +8 more
wiley   +1 more source