Results 61 to 70 of about 3,128,159 (361)

Alternative Models for Anticancer Drug Discovery From Natural Products Using Binary Tumor‐Microenvironment‐on‐a‐Chip

Advanced Science, EarlyView.
This study presents a binary tumor‐microenvironment‐on‐a‐chip (T‐MOC) system incorporating multicellular tumor spheroids (MCTs) as an alternative preclinical platform to evaluate the efficacy of anticancer natural products. The T‐MOC model reproduces in vivo drug delivery barriers and physiological conditions, enabling morphological analysis to predict
Youngwon Kim, Si Hyeon Chae, Dahae Lee, Bum Soo Lee, Jiseok Lim, Hyo‐Il Jung, Ki Hyun Kim, Bongseop Kwak   +7 more
wiley   +1 more source

Role of microRNA in oncogenesis of pituitary tumors and their practical significance [PDF]

Терапевтический архив, 2016
Microribonucleic acids (miRNAs) are a class of noncoding RNAs that regulate posttranscriptional gene expression. These molecules are regulators of cell proliferation, metabolism, apoptosis, and differentiation.
A M Lapshina, P M Khandaeva, Zh E Belaya, L Ya Rozhinskaya, G A Melnichenko   +4 more
doaj   +1 more source

The clinical characteristics and gene mutations associated with thyroid hormone resistance syndrome coexisting with pituitary tumors

Frontiers in Endocrinology, 2023
AimsResistance to thyroid hormone (RTH) and pituitary tumors are both rare diseases, and the differential diagnosis of these two diseases is difficult in some cases. There are also patients who have both conditions, making diagnosis more difficult.
Junyu Zhao, Lusi Xu, Chunyu Li, Fei Wang, Lin Liao, Jianjun Dong   +5 more
doaj   +1 more source

Advanced Image‐Guidance and Surgical‐Navigation Techniques for Real‐Time Visualized Surgery

Advanced Science, EarlyView.
This review comprehensively summarizes advances in surgical navigation, covering both established and emerging intraoperative imaging technologies. It highlights mechanisms, advantages, limitations, and clinical applications, while emphasizing interdisciplinary collaboration.
Xiaoxiao Fan, Xiaolong Liu, Qiming Xia, Guoqiao Chen, Jiaxi Cheng, Zhaoqi Shi, Yifeng Fang, Parikshit Asutosh Khadaroo, Jun Qian, Hui Lin   +9 more
wiley   +1 more source

Evaluation of the expression of necroptosis pathway mediators and its association with tumor characteristics in functional and non-functional pituitary adenomas

BMC Endocrine Disorders, 2022
Background Pituitary adenomas impose a burden of morbidity on patients and characterizing the molecular mechanisms underlying its pathogenesis received remarkable attention.
Mohammad E. Khamseh, Alireza Sheikhi, Zahra Shahsavari, Mohammad Ghorbani, Hamideh Akbari, Mehrnaz Imani, Mahshid Panahi, Alimohammad Alimohammadi, Maryam Ameri, Shima Nazem, Vahid Salimi, Masoumeh Tavakoli-Yaraki   +11 more
doaj   +1 more source

Mechanisms and Pathophysiological Significance of Insulin Resistance in Offspring With Intrauterine Growth Restriction Mediated by Hepatic GR/miR‐1224 Programming

Advanced Science, EarlyView.
This work found that early‐stage insulin sensitization but late‐stage insulin resistance in prenatal caffeine exposure (PCE)‐ induced intrauterine growth restriction (IUGR) offspring may be related to the hepatic AGEs accumulation via intrauterine GR/miR‐1224 programming by glucocorticoids.
Yongguo Dai, Xiaoling Guo, Pengxia Yu, Dingmei Zhang, Hao Kou, Hui Wang   +5 more
wiley   +1 more source

An efficient deep learning model for brain tumour detection with privacy preservation

CAAI Transactions on Intelligence Technology, EarlyView., 2023
Abstract Internet of medical things (IoMT) is becoming more prevalent in healthcare applications as a result of current AI advancements, helping to improve our quality of life and ensure a sustainable health system. IoMT systems with cutting‐edge scientific capabilities are capable of detecting, transmitting, learning and reasoning.
Mujeeb Ur Rehman, Arslan Shafique, Imdad Ullah Khan, Yazeed Yasin Ghadi, Jawad Ahmad, Mohammed S. Alshehri, Mimonah Al Qathrady, Majed Alhaisoni, Muhammad H. Zayyan   +8 more
wiley   +1 more source

TSH Ligand‐Based CAR‐T Cell Effectively Eradicates TSHR‐Positive Thyroid Cancer with Favorable Safety Profile

Advanced Science, EarlyView.
TSHR is highly expressed in differentiated thyroid cancer (DTC), making it an ideal target for adoptive immune cell therapy. A novel Ligand‐based TSH‐CAR‐T cell approach effectively eradicated TSHR‐positive thyroid tumors in vitro and accomplished full remission in tumor models with favorable safety profile, highlighting that TSH‐CAR‐T cells could ...
Fei Wang, Hui Zuo, Li Liu, Shiyuan Wang, Haifang Zhao, Zhao Liu, Gang Wang, Zhao Liu, Junnian Zheng, Chuan Xu, Hongwei Du   +10 more
wiley   +1 more source

Causal relationship between gut microbiota and pituitary neuroendocrine tumors: a bidirectional Mendelian randomization

Discover Oncology
Background Previous observational studies have hinted at a connection between the gut microbiota and pituitary neuroendocrine tumors, yet the causal nature of this relationship remains uncertain.
Wencai Wang, Menghao Liu, Zun Wang, Wei Ye, Xianfeng Li   +4 more
doaj   +1 more source

Micro/Nanorobots for Combating Brain Disorders: Challenges, Advances, and Perspectives

Advanced Science, EarlyView.
Micro/nanorobots (MNRs) offer a transformative approach for precision therapy in brain disorders. By overcoming biological barriers and enabling controlled propulsion, targeted delivery, and real‐time imaging/tracking, MNRs pave the way toward effective, minimally invasive treatments. This review outlines the interplay between brain disease challenges,
Qi Zhang, Dong Sun
wiley   +1 more source