Results 201 to 210 of about 194,517 (249)

Myosin-binding protein C N-terminal domains slow Ca²⁺ dissociation from cardiac thin filaments. [PDF]

J Biol Chem
Hauck GT, Wong FL, Klass MM, Kanassatega RS, Lepak VC, Bunch TA, Tardiff JC, Colson BA.   +7 more
europepmc   +1 more source

Pulsed Electromagnetic Field Exposure Attenuates Ultraviolet B-Induced Dermal Collagen Loss in Association with A2A Adenosine Receptor Signaling. [PDF]

Int J Mol Sci
Byun KA, Lee JI, Oh S, Kim SE, Seo SB, Son KH, Byun K.   +6 more
europepmc   +1 more source

Extending Peptide Ligation to Acidic pH and Junctions Comprising Glycosylated and Phosphorylated Amino Acids

Angewandte Chemie International Edition, EarlyView.
A pyridine‐containing ligation auxiliary eliminates a major bottleneck of peptide ligation chemistry. The extended range of applicable pH values (2.0–7.5) in the ligation reaction helps to avoid epimerization. Native chemical ligation (NCL) proceeds at virtually any junction, including reactions at β‐branched amino acids, as well as O‐glycosylated or O‐
Sebastian Trunschke, Antonia Feida, Hendrik Hanebrink, Arseniy Galashov, Alina Herfort, Oliver Seitz   +5 more
wiley   +1 more source

Phosphorylation deficient inducible cAMP early repressor (ICER) modulates tumorigenesis and survival in a transgenic zebrafish (Danio rerio) model of melanoma

Biology Open
Justin Wheelan, Melissa Spigelman, Angelo Cirinelli, James Reilly, Carlos A. Molina   +4 more
doaj   +1 more source

An activator-free method for the synthesis of nucleotide 5'-5' triphosphate mRNA capping agent. [PDF]

RSC Adv
Tam E, Barát V, Saw TY, Liao KC, Wan Y, Chen S, Ho YS, Lim YH.   +7 more
europepmc   +1 more source

Curcumin Alleviates Endometriosis in Sexually Mature Female Mice by Targeting PKA and Inhibiting De Novo Estrogen Synthesis. [PDF]

Biomedicines
Zhao H, Chen X, Zhang S, Zhang J, Wang Y, Xia Z, Wang H, Xu Z.   +7 more
europepmc   +1 more source

Isolation, Structural Elucidation, and Anti-Melanogenic Activity of a Novel Pectic Polysaccharide From Alhagi camelorum Fisch. [PDF]

Chem Biodivers
Liu Z, Han S, Xu N, Abudukelimu N, Zhao J.   +4 more
europepmc   +1 more source

Click‐to‐Release Reactivity of Quaternary Anilinium Tetrazines Enables Cascade Assembly of Multifunctional Biomolecular Scaffolds

Angewandte Chemie International Edition, EarlyView.
Click chemistry has evolved from making covalent connections to also breaking bonds. Here, a cascade assembly is reported that combines these maneuvers to build multifunctional biomolecular scaffolds in a modular one‐pot reaction. The unifying azide release‐tetrazine hub clicks with a trans‐cyclooctene tag, rapidly liberates N,N‐dimethylaniline to ...
Markus Staudt, Christian B. M. Poulie, Andreas Löffler, Peter R. Meinig, Riley J. Deutsch‐Williams, Barbara Herrmann, Ralph Weissleder, Hannes Mikula, Jonathan C. T. Carlson, Matthias M. Herth   +9 more
wiley   +1 more source

Molecular mechanisms, pathogenesis and therapeutic advances of <i>Candida albicans</i> in oral candidiasis. [PDF]

Front Cell Infect Microbiol
Sahu BK, Debta P, Patra SK, Sahu MC, Mohanta TK, Panda SK.   +5 more
europepmc   +1 more source

Discovery of the Cyclic Form of MRI pH‐Sensor Z‐OMPD Enables >5% 13C Hyperpolarization by SABRE

Angewandte Chemie International Edition, EarlyView.
With “c‐OMPD”, we discovered a previously unknown 5‐membered lactol structure that arises from the homoaldol condensation of the central metabolite pyruvic acid. We demonstrate that the cyclization equilibrium is of crucial importance for OMPD's function as MRI‐based pH sensor and achieve for the first time 13C polarization levels (>5%) by SABRE in the
Juanita Ferreira, Ivan A. Trofimov, Martin Grashei, Adriana Sacristán‐Martín, Alexander Huber, David Schleicher, Oleksiy Khavryuchenko, Franz Schilling, Andreas B. Schmidt, Max von Delius   +9 more
wiley   +1 more source