Results 181 to 190 of about 194,517 (249)

A nuclear ERK-ATF5 axis coordinates mitochondrial metabolism and thermogenic gene expression in brown adipocytes. [PDF]

J Endocrinol
Jang HJ, Suh Y, Tian J, Lee HY, Moon JS, Nga HT, Nguyen TL, Abdillah AM, Lim GM, Choi DW, Kim C, Kwon Y, Yi HS.   +12 more
europepmc   +1 more source

Interpretable Deep Supramolecular Language Modeling for Cocrystal Design: PCA-Augmented <i>DeepCocrystal</i> Screening of Picolinamide, Nicotinamide, and Isonicotinamide Systems. [PDF]

Molecules
Bozkurt B, Yilmaz A, Ogruc Ildiz G, Fausto R.   +3 more
europepmc   +1 more source

PKA signalling in cercariae and somules of 'Schistosoma mansoni'

Schistosoma mansoni is a parasitic trematode that is the causative agent of human intestinal schistosomiasis, a neglected tropical disease that is considered secondonly to malaria in terms of importance.
Hirst, Natasha Lana
core  

Chlorination‐Driven BODIPY Fluorescent Probes for the Selective Monitoring of Myeloperoxidase Activity in Cells and Inflamed Mouse Models

Angewandte Chemie, EarlyView.
A meso‐carboxamide‐substituted BODIPY fluorescent probe reports myeloperoxidase (MPO) activity via electrophilic chlorination by MPO‐derived HOCl, generating a highly emissive chlorinated product with a ca. 40 nm bathochromic shift. Applications in quantitative MPO assays, cellular imaging of MPO‐derived HOCl, redox‐dependent discrimination of cancer ...
Siyoung Cho, Yongyang Luo, Jeehyeon Bae, Youngmi Kim   +3 more
wiley   +2 more sources

A Sesquiterpenoid from <i>Schizophyllum commune</i> Protects C17.2 Neural Stem Cells Against Oxidative Stress Through Modulation of GPCR-Associated Signaling Pathways. [PDF]

Int J Mol Sci
Li L, Zou G, Wang Q, Jiang H, Wu X, Zhao J, Zhang H, Wang X, Li S.   +8 more
europepmc   +1 more source

Click‐Spaltung quartärer Anilinium‐Tetrazine ermöglicht Kaskadenaufbau multifunktioneller biomolekularer Gerüste

Angewandte Chemie, EarlyView.
Die Click‐Chemie hat sich von dem Aufbau kovalenter Bindungen hin zum Spalten von Bindungen weiterentwickelt. Hier wird über einen Kaskaden‐Aufbau berichtet, der diese Verfahren kombiniert, um multifunktionale biomolekulare Gerüste in einer modularen Ein‐Topf‐Reaktion aufzubauen.
Markus Staudt, Christian B. M. Poulie, Andreas Löffler, Peter R. Meinig, Riley J. Deutsch‐Williams, Barbara Herrmann, Ralph Weissleder, Hannes Mikula, Jonathan C. T. Carlson, Matthias M. Herth   +9 more
wiley   +1 more source

Engineering Rapid Payload Release Rate in 1,6‐Elimination Processes of Self‐Immolative Linkers

Angewandte Chemie, EarlyView.
The payload release rate of self‐immolative linkers was greatly improved through stabilization of an intermediate carbocation, thereby achieving an up to 10 000‐fold improvement in rate constant. Furthermore, lipophilicity was identified as another factor that affects the release rate. This new strategy is applicable to different payloads and different
Albert Marten Schulte, Gülbahar Bozan, Francesca Amoroso, Bart Cornelissen, Wiktor Szymanski   +4 more
wiley   +2 more sources

Mechanistic Insights Into the Anti-Constipation Potential of Xiaogan Jianwei Formula: Integration of HPLC-Q-TOF MS/MS, Network Pharmacology, In Vivo Validation, and Gut Microbiota. [PDF]

Biomed Chromatogr
Li T, Wang Y, Du B, Mao J, Liu S, Wu S, Ye Q, Lin N, Wu S, Lei H, Zhang X.   +10 more
europepmc   +1 more source

Entdeckung der cyclischen Form des MRT‐pH‐Sensors Z‐OMPD ermöglicht >5% 13C‐Hyperpolarisation durch SABRE

Angewandte Chemie, EarlyView.
Mit „c‐OMPD“ entdeckten wir eine bislang unbekannte fünfgliedrige Lactolstruktur, die durch Homoaldolkondensation des zentralen Metaboliten Brenztraubensäure entsteht. Wir zeigen, dass das Cyclisierungsgleichgewicht für die Funktion von OMPD als MRT‐basierte pH‐Sonde von entscheidender Bedeutung ist, und erreichen erstmals eine 13C‐Polarisation von >5 %
Juanita Ferreira, Ivan A. Trofimov, Martin Grashei, Adriana Sacristán‐Martín, Alexander Huber, David Schleicher, Oleksiy Khavryuchenko, Franz Schilling, Andreas B. Schmidt, Max von Delius   +9 more
wiley   +1 more source

Subpocket-Aware Fragment-Based Docking Pipeline for Kinase Ligand Design: Methodology and a PKA Case Study. [PDF]

J Chem Inf Model
Buchthal K, Kramer PL, Hubach D, Bach G, Wagner N, Krieger J, Klöpper M, Daude M, Diederich WE, Volkamer A.   +9 more
europepmc   +1 more source