Results 171 to 180 of about 194,517 (249)

The cerebrospinal fluid-contacting nucleus CGRP-RAMP1-PKA signaling pathway mediates trigeminal neuralgia and its mechanism. [PDF]

Korean J Pain
Gui B, Bai Y, Zhang Y, Yan W, Yang Z, Wang X, Qian J, Peng Y, Zhang L.   +8 more
europepmc   +1 more source

Nahinfrarot‐Photoschalten durch direkte Anregung—die nächste Herausforderung

Angewandte Chemie, EarlyView.
Molekulare Photoschalter können endlich direkt mit Licht aus dem Nahinfrarotbereich angeregt werden. Dieser Kurzaufsatz fasst den derzeitigen Entwicklungsstand, die Designprinzipien für niedrigenergetische Lichtresponsivität und die dadurch möglichen außergewöhnlichen Anwendungen zusammen.
Diptiprava Sahoo, Elias Ciekalski, Henry Dube   +2 more
wiley   +1 more source

1,3-bis(2,4,6-trinitrophenylaminooxy)propane and its 4-cyano-2,6-dinitrophenyl congener: Synthesis and properties

Open Chemistry, 2003
Covaci Irina, Ionita Petre, Caproiu Miron, Socoteanu Radu, Constantinescu Titus, Balaban Alexandru   +5 more
doaj   +1 more source

Ultrasonic Reporter of Kinase Activity. [PDF]

ACS Nano
Yang JW, Jin Z, Wang TY, Shapiro MG.
europepmc   +1 more source

Characterization of a Fungal Modular Polyketide Synthase System Reveals an Unusual Strategy for Polyketide Chain Initiation

Angewandte Chemie, EarlyView.
Fungal modular polyketide synthases (PKSs) remain largely unexplored. Functional characterization of the LasC/LasD assembly line established its role in strasseriolide C biosynthesis and suggested an unexpected strategy for chain initiation, in which a malonyl unit is transferred from the module 2 acyl carrier protein (ACP) domains to the loading ACP ...
Qiaolin Ji, Chao Peng, Shuhan He, Bin‐Tao Peng, Wei‐Guang Wang, Yudai Matsuda   +5 more
wiley   +2 more sources

Harmine selectively enhances human beta cell identity markers and function via protein kinase A pathways. [PDF]

Diabetologia
Wang P, Kumar K, Lambertini L, Liu H, Wood O, Chen S, Pillard A, Scott DK, Paulo JA, Gygi SP, Khamrui S, Mueller S, Garcia-Ocana A, Karakose E, Lazarus MB, DeVita RJ, Stewart AF.   +16 more
europepmc   +1 more source

Synthesis of Ladder and Flexible Polysulfonimides Directly From Anionic Monomers: Investigating Structure–Property Convergence in Succinonitrile–Polymer Electrolyte Blends

Angewandte Chemie, EarlyView.
Direct synthesis of sulfonimide‐based polymers of intrinsic microporosity enables comparison with compositionally similar flexible analogs. Incorporation of a common pore‐filling transport medium drives these fundamentally different polymer architectures toward similar bulk conductivity and mechanical properties while revealing distinct microscopic ion‐
Abraham Herzog‐Arbeitman, Pablo Leon, Benedikt S. Schreib, KyuJung Jun, Jurgis Ruza, Vanesa Munoz Perales, Yang Shao‐Horn, Rafael Gomez‐Bombarelli, Jeremiah A. Johnson   +8 more
wiley   +2 more sources

GPR81 Regulates MCT1 Membrane Translocation Through a PKA-Dependent Signaling Pathway in Rat Podocytes. [PDF]

Int J Mol Sci
Grochowalska K, Szrejder M, Audzeyenka I, Piwkowska A.   +3 more
europepmc   +1 more source

Synthesis of Large‐ and Medium‐Sized Heterobiaryl Atropisomeric Rings and Atropopeptides by Catalytic Intramolecular SNAr

Angewandte Chemie, EarlyView.
Catalytic, intramolecular N‐heterocycle arylation by nucleophilic aromatic substitution (SNAr) is now available for synthesis of highly strained macrocycles and medium‐sized heterobiaryl atropisomeric rings, including atropopeptides. Key to the approach is the ability to generate a strong base catalytically, taking advantage of base‐embedding ...
Alireza Abbasi Kejani, Paritosh Dey, Nicholas H. Stillman, Daniel M. Andrade, Michal Šimek, Martin Dračínský, Daniel Bím, Paulo H. S. Paioti   +7 more
wiley   +2 more sources

Erweiterung der Peptidligation auf Saure pH‐Bereiche und Schnittstellen mit Glykosylierten und Phosphorylierten Aminosäuren

Angewandte Chemie, EarlyView.
Ein pyridinhaltiges Ligationsauxiliar beseitigt einen wesentlichen Engpass der Peptidligationschemie. Der für die Ligation nutzbare pH‐Bereich von 2,0–7,5 hilft, Epimerisierung zu vermeiden. Die native chemische Ligation (NCL) verläuft an praktisch jeder Ligationsstelle, einschließlich Reaktionen an β‐verzweigten sowie O‑glykosylierten oder O ...
Sebastian Trunschke, Antonia Feida, Hendrik Hanebrink, Arseniy Galashov, Alina Herfort, Oliver Seitz   +5 more
wiley   +1 more source