STAT3, a hub protein of cellular signaling pathways, is triggered by β-hexaclorocyclohexane [PDF]
, 2018 Background: Organochlorine pesticides (OCPs) are widely distributed in the environment and their toxicity is mostly associated with the molecular mechanisms of endocrine disruption.
Altieri, F +7 more
core +2 more sources
PKM2 in carcinogenesis and oncotherapy
Oncotarget, 2017 Tumor cell metabolism is characterized by abundant glucose consumption and aerobic glycolysis. And pyruvate kinase M2 (PKM2) plays a decisive role in glycolysis, significantly contributing to the Warburg effect, tumor growth, angiogenesis, cell division, metastasis and apoptosis.
He, Xia +7 more
openaire +2 more sources
Nuclear PKM2 regulates the Warburg effect [PDF]
Cell Cycle, 2013 Pyruvate kinase is a rate-limiting glycolytic enzyme. The PKM1 and PKM2 isoforms result from mutually exclusive alternative splicing of the PKM pre-mRNA. PKM2 rather than PKM1 regulates the Warburg effect and tumorigenesis by poorly understood mechanisms.
Weiwei, Yang, Zhimin, Lu
openaire +2 more sources
The role of the HIF‐1α/ALYREF/PKM2 axis in glycolysis and tumorigenesis of bladder cancer
Cancer Communications, 2021 Background As a rate‐limiting enzyme of glycolysis, pyruvate kinase muscle isozyme M2 (PKM2) participates in tumor metabolism and growth. The regulatory network of PKM2 in cancer is complex and has not been fully studied in bladder cancer.
Jing‐Zi Wang +12 more
doaj +1 more source
Modulation of PKM alternative splicing by PTBP1 promotes gemcitabine resistance in pancreatic cancer cells [PDF]
, 2015 Pancreatic ductal adenocarcinoma (PDAC) is an aggressive and incurable disease. Poor prognosis is due to multiple reasons, including acquisition of resistance to gemcitabine, the first-line chemotherapeutic approach.
Bielli, P +7 more
core +2 more sources
Targeting Glycolysis with Epigallocatechin-3-Gallate Enhances the Efficacy of Chemotherapeutics in Pancreatic Cancer Cells and Xenografts. [PDF]
, 2019 Pancreatic cancer is a complex disease, in need of new therapeutic approaches. In this study, we explored the effect and mechanism of action of epigallocatechin-3-gallate (EGCG), a major polyphenol in green tea, alone and in combination with current ...
Hackman, Robert M +3 more
core +1 more source
Structural basis of PKM2 regulation [PDF]
Protein & Cell, 2015 Alterations in cell metabolism are a characteristic of many cancers. Cancer cells are metabolically rewired to support their rapid growth (Kim and Dang, 2006; Vander Heiden et al., 2009). The best-characterized metabolic phenotype observed in tumor cells is aerobic glycolysis, also known as the Warburg effect, which is a shift of ATP generation from ...
openaire +2 more sources
MiR-1286 inhibits lung cancer growth through aerobic glycolysis by targeting PKM2
Archives of Medical Science, 2019 Introduction This study aims to explore the effects of microRNA-1286 (miR-1286) on the development of non-small cell lung cancer (NSCLC) via the aerobic glycolysis pathway by targeting pyruvate kinase muscle isozyme M2 (PKM2).
Hui Li +6 more
doaj +1 more source
Correction to: PKM2, function and expression and regulation [PDF]
Cell & Bioscience, 2019 [This corrects the article DOI: 10.1186/s13578-019-0317-8.].
Ze Zhang +5 more
openaire +3 more sources
Pyruvate kinase M2 plays a dual role on regulation of the EGF/EGFR signaling via E-cadherin-dependent manner in gastric cancer cells. [PDF]
PLoS ONE, 2013 BACKGROUND AND AIMS: EGFR activation and PKM2 expression are instrumental in tumorigenesis. EGFR activation regulates PKM2 functions in a subcellular compartment-dependent manner and promotes gene transcription and tumor growth.
Le-Yi Wang +8 more
doaj +1 more source