Results 21 to 30 of about 18,059 (264)

Non-Metabolic Functions of PKM2 Contribute to Cervical Cancer Cell Proliferation Induced by the HPV16 E7 Oncoprotein

Viruses, 2021
Pyruvate kinase M2 (PKM2) mainly catalyzes glycolysis, but it also exerts non-glycolytic functions in several cancers. While it has been shown to interact with the human papillomavirus 16 (HPV16) E7 oncoprotein, the functional significance of PKM2 in HPV-
Seoung-Ae Lee, Charles Ho, Madison Troxler, Chin-Yo Lin, Sang-Hyuk Chung   +4 more
doaj   +1 more source

Mediation of PKM2-dependent glycolytic and non-glycolytic pathways by ENO2 in head and neck cancer development

Journal of experimental & clinical cancer research : CR, 2023
Background Enolase 2 (ENO2) is a crucial glycolytic enzyme in cancer metabolic process and acts as a “moonlighting” protein to play various functions in diverse cellular processes unrelated to glycolysis.
Li-xia Gao, Fan Yang, D. Tang, Zhigang Xu, Yan Tang, Donglin Yang, Deping Sun, Zhongzhu Chen, Yong Teng   +8 more
semanticscholar   +1 more source

Overexpressed PKM2 promotes macrophage phagocytosis and atherosclerosis

Animal Models and Experimental Medicine, 2023
Background The expression of pyruvate kinase muscle 2 (PKM2) is augmented in macrophages of patients with atherosclerotic coronary artery disease. The role of PKM2 in atherosclerosis is to be determined.
Xiaochen Gai, Fangming Liu, Yuting Wu, Baohui Zhang, Bufu Tang, Kezhuo Shang, Lianmei Wang, Haihong Zhang, Yixin Chen, Shuhui Yang, Weiwei Deng, Peng Li, Jing Wang, Hongbing Zhang   +13 more
doaj   +1 more source

PKM2 Enters the Morpheein Academy [PDF]

Molecular Cell, 2012
In this issue of Molecular Cell, Gao et al. (2012) show that the glycolytic enzyme PKM2, in its dimeric form, possesses protein kinase activity and phosphorylates STAT3 in the nucleus, thereby driving expression of genes that promote transformation.
Galina Semenova, Jonathan Chernoff
openaire   +3 more sources

A PKM2 signature in the failing heart [PDF]

Biochemical and Biophysical Research Communications, 2015
A salient feature of the failing heart is metabolic remodeling towards predominant glucose metabolism and activation of the fetal gene program. Sunitinib is a multitargeted receptor tyrosine kinase inhibitor used for the treatment of highly vascularized tumors. In diabetic patients, sunitinib significantly decreases blood glucose.
Dale J. Hamilton, Meredith L. Rees, Janani Subramaniam, Yuanteng Li, O. Howard Frazier, Heinrich Taegtmeyer, Heinrich Taegtmeyer   +6 more
openaire   +3 more sources

Lactylation of PKM2 Suppresses Inflammatory Metabolic Adaptation in Pro-inflammatory Macrophages

International Journal on Biological Sciences, 2022
Emerging evidence suggests that metabolic adaptation is a vital hallmark and prerequisite for macrophage phenotype transition. Pyruvate kinase M2 (PKM2) is an essential molecular determinant of metabolic adaptions in pro-inflammatory macrophages.
Jizhuang Wang, Peilang Yang, Tianyi Yu, M. Gao, Dan Liu, Jie Zhang, Chen-Che Lu, Xuelian Chen, Xiong Zhang, Yan Liu   +9 more
semanticscholar   +1 more source

Exosome‐delivered circRNA promotes glycolysis to induce chemoresistance through the miR‐122‐PKM2 axis in colorectal cancer

Molecular Oncology, 2020
Malignant tumors, including colorectal cancer (CRC), usually rely on ATP generation through aerobic glycolysis for both rapid growth and chemotherapy resistance.
Xinyi Wang, Haiyang Zhang, Haiou Yang, M. Bai, T. Ning, T. Deng, Rui Liu, Q. Fan, Kegan Zhu, Jialu Li, Yang Zhan, G. Ying, Y. Ba   +12 more
semanticscholar   +1 more source

Jmjd4 Facilitates Pkm2 Degradation in Cardiomyocytes and Is Protective Against Dilated Cardiomyopathy

Circulation, 2023
Background: A large portion of idiopathic and familial dilated cardiomyopathy (DCM) cases have no obvious causal genetic variant. Although altered response to metabolic stress has been implicated, the molecular mechanisms underlying the pathogenesis of ...
Yansong Tang, Mengying Feng, Yang Su, Teng Ma, Hongjie Zhang, Hongchun Wu, Xin Eric Wang, Shuyue Shi, Ying Zhang, Yawei Xu, Shijun Hu, Ke Wei, Dachun Xu   +12 more
semanticscholar   +1 more source

PKM2-mediated metabolic reprogramming of microglia in neuroinflammation. [PDF]

Cell Death Discov
Abstract Microglia, the resident immune cells of the central nervous system, undergo metabolic reprogramming during neuroinflammation, playing a crucial role in the pathogenesis of neurological disorders such as Parkinson’s disease. This review focuses on Pyruvate Kinase M2 (PKM2), a key glycolytic enzyme, and its impact on microglial ...
Zhang Q, Wang SS, Zhang Z, Chu SF.
europepmc   +4 more sources

ALKBH5‐induced circular RNA NRIP1 promotes glycolysis in thyroid cancer cells by targeting PKM2

Cancer Science, 2023
Although circular RNAs (circRNAs) are involved in cell proliferation, differentiation, apoptosis, and invasion, the underlying regulatory mechanisms of circRNAs in thyroid cancer have not been fully elucidated.
Xiaoyue Ji, Chengzhou Lv, Jiapeng Huang, W. Dong, Wei Sun, H. Zhang   +5 more
semanticscholar   +1 more source