Results 1 to 10 of about 23,565 (226)

ZNF460 Promotes GSDME-Driven Pyroptosis via PKM2 Transcriptional Activation in Aortic Dissection [PDF]

Reviews in Cardiovascular Medicine
Background: Aortic dissection (AD) is a cardiovascular emergency with high mortality; however, the underlying molecular pathophysiology of AD remains incompletely understood. Pyroptosis, a proinflammatory form of programmed cell death,
Quanlin Yang, Xin Shao, Zihe Zheng, Mingliang Li, Changbo Xiao, Bo Chen, Guowei Tu, Ben Huang, Xiaofu Dai   +8 more
doaj   +2 more sources

Overexpressed PKM2 promotes macrophage phagocytosis and atherosclerosis

Animal Models and Experimental Medicine, 2023
Background The expression of pyruvate kinase muscle 2 (PKM2) is augmented in macrophages of patients with atherosclerotic coronary artery disease. The role of PKM2 in atherosclerosis is to be determined.
Xiaochen Gai, Fangming Liu, Yuting Wu, Baohui Zhang, Bufu Tang, Kezhuo Shang, Lianmei Wang, Haihong Zhang, Yixin Chen, Shuhui Yang, Weiwei Deng, Peng Li, Jing Wang, Hongbing Zhang   +13 more
doaj   +3 more sources

Dimeric PKM2 in chondrocytes impairs mitochondrial homeostasis in osteoarthritis [PDF]

Cell Death and Disease
Cartilage degradation is considered a hallmark of end-stage osteoarthritis (OA), characterized by significant alterations in the extracellular matrix (ECM).
Bo Liu, Yun Liang, Chenzhong Wang, Ziyu Weng, Yi Yang, Yi Shi, Chi Zhang   +6 more
doaj   +2 more sources

Upregulated expression of pyruvate kinase M2 mRNA predicts poor prognosis in lung adenocarcinoma [PDF]

PeerJ, 2020
Background Pyruvate kinase M2 (PKM2) is critical regulator contributing to Warburg effect. However, the expression pattern and prognostic value of PKM2 remain unknown in lung adenocarcinoma (LUAD). The aim of this study is to clarify the prognostic value
Guiping Wang, Yingying Zhong, Jiecong Liang, Zhibin Li, Yun Ye   +4 more
doaj   +2 more sources

Altered mitochondrial function and energy metabolism is associated with a radioresistant phenotype in oesophageal adenocarcinoma [PDF]

, 2014
Neoadjuvant chemoradiation therapy (CRT) is increasingly the standard of care for locally advanced oesophageal cancer. A complete pathological response to CRT is associated with a favourable outcome.
Lynam-Lennon, Niamh, Maguire, Aoife, Maher, Stephen G., Muldoon, Cian, O'Sullivan, Jacintha, O’Sullivan, Jacintha, Phelan, James, Reynolds, John V.   +7 more
core   +13 more sources

The transglutaminase type 2 and pyruvate kinase isoenzyme M2 interplay in autophagy regulation [PDF]

, 2015
Autophagy is a self-degradative physiological process by which the cell removes worn-out or damaged components. Constant at basal level it may become highly active in response to cellular stress. The type 2 transglutaminase (TG2), which accumulates under
Belkin, Brady, Cantley, Caputo, Carnero, Cornwall, Cuervo, Cuervo, De Strooper, Debnath, Denk, Deutsch, Dikic, Djavaheri-Mergny, Eckert, Esposito, Facchiano, Fesus, Graham, Griffin, Griffin, Ha, Han, Johansen, Johansen, Ju, Khosla, Khosla, Komatsu, Kumar, Ledesma, Lenz, Levine, Levine, Liao, Liu, Lopez-Berestein, Mazurek, Mehta, Murphy, Ortona, Ozpolat, Palmieri, Piacentini, Piacentini, Piacentini, Piacentini, Piacentini, Piacentini, Piacentini, Piacentini, Piacentini, Rao, Rice, Rodolfo, Saito, Semenza, Semenza, Tavernarakis, Wang, Wang, White   +61 more
core   +5 more sources

USP4 promotes the proliferation and glucose metabolism of gastric cancer cells by upregulating PKM2.

PLoS ONE, 2023
BackgroundThe pyruvate kinase enzyme PKM2 catalyzes the final step in glycolysis and converts phosphoenolpyruvate (PEP) to pyruvate. PKM2 is often overexpressed in cancer and plays a role in the Warburg effect.
Yuanyuan Chen, Yunfei Guo, Mei Yuan, Song Guo, Shuaishuai Cui, Dahu Chen   +5 more
doaj   +1 more source

Non-Metabolic Functions of PKM2 Contribute to Cervical Cancer Cell Proliferation Induced by the HPV16 E7 Oncoprotein

Viruses, 2021
Pyruvate kinase M2 (PKM2) mainly catalyzes glycolysis, but it also exerts non-glycolytic functions in several cancers. While it has been shown to interact with the human papillomavirus 16 (HPV16) E7 oncoprotein, the functional significance of PKM2 in HPV-
Seoung-Ae Lee, Charles Ho, Madison Troxler, Chin-Yo Lin, Sang-Hyuk Chung   +4 more
doaj   +1 more source

Pyruvate Kinase M2 Mediates Glycolysis Contributes to Psoriasis by Promoting Keratinocyte Proliferation

Frontiers in Pharmacology, 2021
Psoriasis is characterized by keratinocyte proliferation and immune cell infiltration. M2 isoform of pyruvate kinase (PKM2) was reported to have an important role in cell proliferation, which is a rate-limiting enzyme that regulates the final step of ...
Yun-zi Liu, Yun-zi Liu, Ming-yuan Xu, Xiao-yu Dai, Lang Yan, Lei Li, Rui-zhen Zhu, Li-jun Ren, Ji-qian-zhu Zhang, Xiao-fang Zhang, Jin-feng Li, Yi-jun Tian, Wen-jing Shi, Ye-qiang Liu, Chun-lei Jiang, Jiang-bo Zhu, Ji-kuai Chen   +16 more
doaj   +1 more source

Mutations in the PKM2 exon-10 region are associated with reduced allostery and increased nuclear translocation. [PDF]

, 2019
PKM2 is a key metabolic enzyme central to glucose metabolism and energy expenditure. Multiple stimuli regulate PKM2's activity through allosteric modulation and post-translational modifications.
Chen, Tsan-Jan, Cheng, Hsin-Hung, Hsu, Sheng-Chieh, Kung, Hsing-Jien, Liu, Jai-Shin, Liu, Ying-Yuan, Lu, Chien-Hung, Wang, Hung-Jung, Wang, Wen-Ching, Wu, Jing-Wen, Wu, Meng-Chen, Wu, Yu-Fang   +11 more
core   +3 more sources