Pyruvate Kinase M2 Role in Cardiovascular Repair. [PDF]
CellsAdult cardiomyocytes (CMs) lose their proliferative capacity shortly after birth, posing a major challenge for cardiac repair following injury such as myocardial infarction (MI).
Rihan M, Zangi L, Magadum A.
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Protein kinase function of pyruvate kinase M2 and cancer [PDF]
Cancer Cell International, 2020 Pyruvate kinase is a terminal enzyme in the glycolytic pathway, where it catalyzes the conversion of phosphoenolpyruvate to pyruvate and production of ATP via substrate level phosphorylation.
Xun Chen, Shangwu Chen, Dongsheng Yu
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Chlorpromazine affects glioblastoma bioenergetics by interfering with pyruvate kinase M2. [PDF]
Cell Death Dis, 2023 Glioblastoma (GBM) is the most frequent and lethal brain tumor, whose therapeutic outcome - only partially effective with current schemes - places this disease among the unmet medical needs, and effective therapeutic approaches are urgently required.
Abbruzzese C +16 more
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Pyruvate kinase M2: a potential target for regulating inflammation [PDF]
Frontiers in Immunology, 2016 Pyruvate kinase (PK) is the enzyme responsible for catalyzing the last step of glycolysis. Of the four PK isoforms expressed in mammalian cells, PKM2 has generated the most interest due to its impact on changes in cellular metabolism observed in cancer ...
Jose Carlos eAlves-Filho +1 more
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Non-metabolic enzyme function of pyruvate kinase M2 in breast cancer. [PDF]
Front OncolBreast cancer (BC) is a prevalent malignant tumor in women, and its incidence has been steadily increasing in recent years. Compared with other types of cancer, it has the highest mortality and morbidity rates in women.
Jemal M +8 more
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Targeting pyruvate kinase M2 for the treatment of kidney disease. [PDF]
Front PharmacolPyruvate kinase M2 (PKM2), a rate limiting enzyme in glycolysis, is a cellular regulator that has received extensive attention and regards as a metabolic regulator of cellular metabolism and energy.
Chen DQ, Han J, Liu H, Feng K, Li P.
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Pyruvate kinase M2 regulates mitochondrial homeostasis in cisplatin-induced acute kidney injury. [PDF]
Cell Death Dis, 2023 An important pathophysiological process of acute kidney injury (AKI) is mitochondrial fragmentation in renal tubular epithelial cells, which leads to cell death.
Xie W +9 more
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Identification of Natural Compounds as Inhibitors of Pyruvate Kinase M2 for Cancer Treatment. [PDF]
Molecules, 2022 The reliance of tumor cells on aerobic glycolysis is one of the emerging hallmarks of cancer. Pyruvate kinase M2 (PKM2), an important enzyme of glycolytic pathway, is highly expressed in a number of cancer cells.
Sarfraz I +4 more
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Pyruvate Kinase M2 Accelerates Cutaneous Wound Healing via Glycolysis and Wnt/β-Catenin Signaling. [PDF]
Pharmaceutics, 2023 Cutaneous wound healing is a complex and dynamic process with high energy demand. The activation of glycolysis is essential for restoring the structure and function of injured tissues in wounds. Pyruvate kinase M2 (PKM2) is an enzyme that plays a crucial
Kim E +6 more
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Role of pyruvate kinase M2 in regulating sepsis (Review). [PDF]
Mol Med RepGlycolysis occurs in all living organisms as a form of energy supply. Pyruvate kinase M2 (PKM2) is one of the rate‑limiting enzymes in the glycolytic process. PKM2 is considered to serve an important role in several terminal diseases, including sepsis. However, to the best of our knowledge, the specific mechanistic role of PKM2 in sepsis remains to be ...
Hu Y +7 more
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