Results 11 to 20 of about 51,864 (248)

The novelty of profilin 2 in regulating pyruvate kinase M2 nuclear translocation and promoting tumor angiogenesis in lung adenocarcinoma. [PDF]

Respir Res
Background Profilin 2 (PFN2), indispensable in all organisms, is important for cancer initiation and progression. Here, we found PFN2 highly overexpressed in tumor tissues with poor prognosis of Lung adenocarcinoma (LUAD) patients had a novel role in ...
Du X, Ma C, Wang Y, Xu M, Kuang Y, Li M, Wen S, He P, Zhao H, Wang Q.   +9 more
europepmc   +2 more sources

Pyruvate kinase M2 activation maintains mitochondrial metabolism by regulating the interaction between HIF-1α and PGC-1α in diabetic kidney disease. [PDF]

Mol Med
Background Pyruvate kinase isoform M2 (PKM2) activation has been suggested as a potential protective mechanism against kidney injury by improving mitochondrial dysfunction and anaerobic glycolysis. However, the underlying molecular mechanisms are unclear.
Park J, Joo YS, Nam BY, Kim G, Park JT, Yoo TH, Kang SW, Han SH.   +7 more
europepmc   +2 more sources

Hydrogen sulfide coordinates glucose metabolism switch through destabilizing tetrameric pyruvate kinase M2. [PDF]

Nat Commun
Most cancer cells reprogram their glucose metabolic pathway from oxidative phosphorylation to aerobic glycolysis for energy production. By reducing enzyme activity of pyruvate kinase M2 (PKM2), cancer cells attain a greater fraction of glycolytic ...
Wang RH, Chen PR, Chen YT, Chen YC, Chu YH, Chien CC, Chien PC, Lo SY, Wang ZL, Tsou MC, Chen SY, Chiu GS, Chen WL, Wu YH, Wang LH, Wang WC, Lin SY, Kung HJ, Wang LH, Cheng HC, Lin KT.   +20 more
europepmc   +2 more sources

Hypoxic microenvironment-induced exosomes confer temozolomide resistance in glioma through transfer of pyruvate kinase M2. [PDF]

Discov Oncol
Objective Glioma, a malignant primary brain tumor, is notorious for its high incidence rate. However, the clinical application of temozolomide (TMZ) as a treatment option for glioma is often limited due to resistance, which has been linked to hypoxic ...
Li G, Xiong Z, Li Y, Yan C, Cheng Y, Wang Y, Li J, Dai Z, Zhang D, Du W, Men C, Shi C.   +11 more
europepmc   +2 more sources

Pyruvate kinase M2 at a glance [PDF]

Journal of Cell Science, 2015
Reprogrammed metabolism is a key feature of cancer cells. The pyruvate kinase M2 (PKM2) isoform, which is commonly upregulated in many human cancers, has been recently shown to play a crucial role in metabolism reprogramming, gene transcription and cell cycle progression.
Weiwei, Yang, Zhimin, Lu
openaire   +2 more sources

Isoform switch of pyruvate kinase M1 indeed occurs but not to pyruvate kinase M2 in human tumorigenesis. [PDF]

PLoS ONE, 2015
Muscle type of pyruvate kinase (PKM) is one of the key mediators of the Warburg effect and tumor metabolism. Due to alternative splicing, there are at least 12 known isoforms of the PKM gene, of which PKM1 and PKM2 are two major isoforms with only a 23 ...
Cheng Zhan, Li Yan, Lin Wang, Jun Ma, Wei Jiang, Yongxing Zhang, Yu Shi, Qun Wang   +7 more
doaj   +1 more source

Predicting the risk of malignisation of endometrial hyperplasia in reproductive age

Фундаментальная и клиническая медицина, 2020
Aim. Atypical endometrial hyperplasia (AEH) is a strong predictor of endometrial cancer, which is responsible for 80% of endometrial malignancies; out of all patients AEH, 10-50% are further diagnosed with endometrial cancer.
I. M. Ordiyants, A. A. Kuular, A. A. Yamurzina, D. S. Novginov   +3 more
doaj   +1 more source

Pyruvate kinase M2 expression, but not pyruvate kinase activity, is up-regulated in a grade-specific manner in human glioma. [PDF]

PLoS ONE, 2013
Normal tissues express the M1 isoform of pyruvate kinase (PK) that helps generate and funnel pyruvate into the mitochondria for ATP production. Tumors, in contrast, express the less active PKM2 isoform, which limits pyruvate production and spares ...
Joydeep Mukherjee, Joanna J Phillips, Shichun Zheng, John Wiencke, Sabrina M Ronen, Russell O Pieper   +5 more
doaj   +1 more source

Suppressed “Warburg Effect” in Nasopharyngeal Carcinoma Via the Inhibition of Pyruvate Kinase Type M2-Mediated Energy Generation Pathway

Technology in Cancer Research & Treatment, 2020
Warburg effect describes the abnormal energy metabolism in cancer cells and pyruvate kinase type M2 is involved in the regulation of this effect.
Penglong Zhao MBBS, Mengyan Zhou MMed, Ruixiang Chen MBBS, Renjie Su MMed   +3 more
doaj   +1 more source

Human pyruvate kinase M2: A multifunctional protein [PDF]

Protein Science, 2010
AbstractGlycolysis, a central metabolic pathway, harbors evolutionary conserved enzymes that modulate and potentially shift the cellular metabolism on requirement. Pyruvate kinase, which catalyzes the last but rate‐limiting step of glycolysis, is expressed in four isozymic forms, depending on the tissue requirement.
Vibhor, Gupta, Rameshwar N K, Bamezai
openaire   +2 more sources