Results 41 to 50 of about 51,864 (248)
Structure, function and inhibition of poly(ADP-ribose)polymerase, member 14 (PARP14) [PDF]
, 2018 Poly(ADP-ribose)polymerase, member 14 (PARP14, alternatively named ARTD8, BAL2, and COAST6) is an intracellular mono(ADP-ribosyl) transferase. PARP14 transfers a negatively charged ADP-ribose unit from a donor NAD+ molecule onto a target protein, post ...
Levonis, Stephan M +3 more
core +1 more source
Pyruvate Kinase M2 Activates mTORC1 by Phosphorylating AKT1S1 [PDF]
Scientific Reports, 2016 AbstractIn cancer cells, the mammalian target of rapamycin complex 1 (mTORC1) that requires hormonal and nutrient signals for its activation, is constitutively activated. We found that overexpression of pyruvate kinase M2 (PKM2) activates mTORC1 signaling through phosphorylating mTORC1 inhibitor AKT1 substrate 1 (AKT1S1).
Chang-Liang He +13 more
openaire +2 more sources
Frontiers in Pharmacology, 2023 Upregulation of pyruvate kinase M2 (PKM2) is critical for the orchestration of metabolism and inflammation in critical illness, while autophagic degradation is a recently revealed mechanism that counter-regulates PKM2. Accumulating evidence suggests that
Shuang Zhao +15 more
doaj +1 more source
Identification of a serum biomarker panel for the differential diagnosis of cholangiocarcinoma and primary sclerosing cholagnitis [PDF]
, 2018 The non-invasive differentiation of malignant and benign biliary disease is a clinical challenge. Carbohydrate antigen 19-9 (CA19-9), leucine-rich α2-glycoprotein (LRG1), interleukin 6 (IL6), pyruvate kinase M2 (PKM2), cytokeratin 19 fragment (CYFRA21.1)
Blyuss, O +9 more
core +2 more sources
Research progress on the role of PKM2 in the immune response
Frontiers in Immunology, 2022 Pyruvate kinase (PK) is a key enzyme that catalyzes the dephosphorylation of phosphoenolpyruvate (PEP) into pyruvate, and is responsible for the production of ATP during glycolysis.
Chunyan Liu, Chenchen Liu, Rong Fu
doaj +1 more source
Pyruvate kinase M2-specific siRNA induces apoptosis and tumor regression [PDF]
, 2011 Online supplemental material is available at http://www.jem.org/cgi/content/full/jem.20111487/DC1.The development of cancer-specific therapeutics has been limited because most healthy cells and cancer cells depend on common pathways. Pyruvate kinase (PK)
Akinc +33 more
core +1 more source
Parkin Regulates the Activity of Pyruvate Kinase M2 [PDF]
Journal of Biological Chemistry, 2016 Parkin, a ubiquitin E3 ligase, is mutated in most cases of autosomal recessive early onset Parkinson disease. It was discovered that Parkin is also mutated in glioblastoma and other human malignancies and that it inhibits tumor cell growth. Here, we identified pyruvate kinase M2 (PKM2) as a unique substrate for parkin through biochemical purification ...
Liu, Kun +9 more
openaire +2 more sources
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis [PDF]
, 2011 Cancer cells engage in a metabolic program to enhance biosynthesis and support cell proliferation. The regulatory properties of pyruvate kinase M2 (PKM2) influence altered glucose metabolism in cancer.
Davidson, Shawn Michael +11 more
core +1 more source
Impact of limited solvent capacity on metabolic rate, enzyme activities, and metabolite concentrations of S. cerevisiae glycolysis [PDF]
, 2008 The cell's cytoplasm is crowded by its various molecular components, resulting in a limited solvent capacity for the allocation of new proteins, thus constraining various cellular processes such as metabolism.
Barabási, AL +3 more
core +1 more source
Interaction between HERC1 and M2‐type pyruvate kinase
FEBS Letters, 2003 HERC proteins are characterized by having one or more RCC1‐like domains as well as a C‐terminal HECT domain in their amino acid sequences. This has led researchers to suggest that they may act as both guanine nucleotide exchange factors and E3 ubiquitin ligases.
Garcia-Gonzalo, Francesc R +7 more
openaire +2 more sources